A5102842892- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Neurosurgical Procedures and Complications
- Monoclonal and Polyclonal Antibodies Research
- Nicotinic Acetylcholine Receptors Study
- Pneumonia and Respiratory Infections
- Peptidase Inhibition and Analysis
- Proteoglycans and glycosaminoglycans research
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Pleural and Pulmonary Diseases
- Cholesterol and Lipid Metabolism
- Medical Imaging and Pathology Studies
- Psoriasis: Treatment and Pathogenesis
- Anesthesia and Neurotoxicity Research
- Cancer, Stress, Anesthesia, and Immune Response
- Autoimmune and Inflammatory Disorders
- High Altitude and Hypoxia
- Chronic Obstructive Pulmonary Disease (COPD) Research
Japan Pediatric Society
2024
Saitama Medical University
2019-2023
Saitama Medical University Hospital
2013-2022
Lovelace Respiratory Research Institute
2006-2010
Kumamoto University
2007
University of Maryland, Baltimore
2006
MUC1 (MUC1 in humans and Muc1 nonhuman species) is a transmembrane mucin-like glycoprotein expressed epithelial cells lining various mucosal surfaces as well hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, our studies cultured revealed MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting anti-inflammatory role. Here...
Abstract MUC1 (MUC1 in human and Muc1 nonhumans) is a membrane-tethered mucin that interacts with Pseudomonas aeruginosa (PA) through flagellin. In this study, we compared PA pulmonary clearance proinflammatory responses by Muc1−/− mice Muc1+/+ littermates following intranasal instillation of or Compared mice, showed increased clearance, greater airway recruitment neutrophils, higher levels TNF-α KC bronchoalveolar lavage fluid, media flagellin-stimulated alveolar macrophages, tracheal...
Abstract Allergic asthma, an inflammatory disease characterized by the infiltration and activation of various leukocytes, production Th2 cytokines leukotrienes, atopy, also affects function other cell types, causing goblet hyperplasia/hypertrophy, increased mucus production/secretion, airway hyperreactivity. Eosinophilic inflammation is a characteristic feature human recent evidence suggests that eosinophils play critical role in T trafficking animal models asthma. Nicotine...
The current study was conducted to elucidate the mechanism through which TNF-alpha stimulates expression of MUC1, a membrane-tethered mucin. A549 human lung alveolar cells treated with exhibited significantly higher MUC1 protein levels in detergent lysates compared vehicle alone. Increased were correlated mRNA TNF-alpha-treated controls. However, did not alter transcript stability, implying increased de novo transcription induced by cytokine. gene promoter activity transfected...
Muc1 is a heterodimeric mucin that expressed on the apical surface of airway epithelial cells as well hematopoietic cells. Both in vivo and vitro studies revealed suppresses inflammatory responses induced by Pseudomonas aeruginosa (PA). In this study, we sought to determine, using intact animals (C57BL/6 mice), whether expression important during PA infection, how levels are controlled inflammation. Our results showed that: (1) wild-type (WT) mice were initially low, but gradually increased...
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Acute exacerbation of asthma is divided qualitatively into mild, moderate, and severe attacks respiratory failure. This system is, however, not suitable for estimating small changes in condition with time determining the efficacy treatments, because it has a qualitative, but quantitative nature.To evaluate usefulness estimation exacerbation, modified Pulmonary Index Score (mPIS) values were measured 87 asthmatic children (mean age, 5.0 ± 0.4 years) during hospitalization. mPIS was calculated...
Because few studies have epidemiologically evaluated pollen-food allergy syndrome (PFAS), relevant information about this disease is limited in children.We wanted to clarify the epidemiological details of PFAS by creating a questionnaire which enables distinguish class 2 food from that 1.We conducted survey for schoolchildren attending public elementary and junior high schools. In questionnaire, we asked both fruits and/or vegetables allergic rhinitis (AR). was, then, defined as vegetable...
Objectives Standardized criteria for disease activity and end of treatment systemic atopic dermatitis have not been established. The objective this study is to explore the experience using upadacitinib retrospectively, find clues weaning from treatment, determine algorithm setting goals terminating treatment. Methods Fourteen patients treated with between 1 November 2021 31 December 2023 were enrolled in study. Topical anti-inflammatory treatments combined. Treatment outcomes established...
Objective: Pulmonary function and airway inflammation were investigated in stable pre- to late-adolescent asthmatics without long-term control medications compared with those currently medicated asthmatics.Methods: Subjects comprised 34 well-controlled asthmatic children (aged 8.1–18.0 years; group medication). Flow volume curves before after inhaling a β2 agonist, bronchodilator (BD), fractional exhaled nitric oxide (FENO) concentrations measured. All patients attack-free for at least 12...
A 12-year-old boy visited our hospital with complaints of chronic cough and dyspnea. Chest X-ray CT revealed diffuse granular shadow in the bilateral lung fields Tree-in-bud appearance peripheral airways, respectively. Sinusitis was present, restrictive disorder predominantly found pulmonary function. The patient diagnosed DPB, long-term therapy started low-dose clarithromycin (CAM), showed a dramatic response to CAM, improvements both clinical symptoms function within 1-2 months. According...
<b>Background:</b> Airflow limitation and airway inflammation have been suggested to persist even in remitted asthmatic adolescents. <b>Aim:</b> We wanted know the details of airflow adolescents by performing reversibility test (ART) fractional exhaled nitric oxide (FENO) measurements, respectively. <b>Methods:</b> ART FENO were examined for 21 subjects (aged 8 - 18years old) remission. Remission was defined as having no attacks for, at least, 12 months, not taking any asthma medications 3...