A5059748446- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
University of Cincinnati
2023
Case Western Reserve University
2019-2021
Antibiotics are commonly added to poly(methyl methacrylate) (PMMA) by surgeons locally treat infections such as in bone cement for joint replacement surgeries, well implantable antimicrobial "beads". However, this strategy is of limited value high-risk patients where can be recurrent or chronic and otherwise hard treat. Also, when only one drug incorporated applied toward polymicrobial (multiple bacterial species), there a high risk that bacteria develop antibiotic resistance. To combat...
Antibiotic-laden poly(methyl methacrylate) (PMMA) bone cement is used in a variety of applications including temporary spacers for load-bearing arthroplasties and non-load bearing orthopedic revision procedures antibiotic beads to treat infections. Depending upon the surgical preparation technique, properties PMMA can widely vary. The primary objective this work was perform an in-depth structure–function analysis regarding how processing impacted material structural (i.e., porosity)...
Herein, fullerenol (Ful), a highly water-soluble derivative of C60 fullerene with demonstrated antioxidant activity, is incorporated into calcium phosphate cements (CPCs) to enhance their osteogenic ability. CPCs added carboxymethyl cellulose/gelatin (CMC/Gel) are doped biocompatible Ful particles at concentrations 0.02, 0.04, and 0.1 wt v%-1 evaluated for Ful-mediated mechanical performance, in vitro cellular osteogenesis. CMC/gel the highest concentration decrease setting times due...
While periprosthetic joint infections (PJIs) result in a small percentage of patients following arthroplasties, they are challenging to treat if spread into bone and soft tissue. Treatment involves delivering antibiotics using poly(methyl methacrylate) (PMMA) cement. However, antibiotic release is insufficient for prolonged infections. Previous work demonstrated efficacy incorporating insoluble cyclodextrin (CD) microparticles PMMA improve allow post-implantation drug refilling occur...
ABSTRACT Antibiotics are commonly added to poly(methyl methacrylate) (PMMA) by surgeons locally treat infections such as in bone cement for joint replacement surgeries, but also implantable antimicrobial “beads”. However, this strategy is of limited value high risk patients where can be recurrent or chronic and otherwise hard treat. Also when only one drug incorporated applied toward poly-microbial (multiple bacterial species), there a that bacteria develop antibiotic resistance. To combat...