A5005237278- Recommender Systems and Techniques
- Virology and Viral Diseases
- Immune responses and vaccinations
- Advanced Graph Neural Networks
- Orthopaedic implants and arthroplasty
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- Bone Tissue Engineering Materials
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Plant responses to elevated CO2
- Peptidase Inhibition and Analysis
- Gear and Bearing Dynamics Analysis
- Orthopedic Infections and Treatments
- Gut microbiota and health
- Hepatitis C virus research
- Respiratory viral infections research
- Topic Modeling
- Mental Health via Writing
- Hydropower, Displacement, Environmental Impact
- Human Mobility and Location-Based Analysis
- Plant Parasitism and Resistance
- Chemical synthesis and alkaloids
- Cambodian History and Society
- Histone Deacetylase Inhibitors Research
Zhejiang Ocean University
2023-2024
Zhejiang University
2023-2024
Nanjing Drum Tower Hospital
2020-2024
University of California, San Francisco
2024
Nanjing Medical University
2024
National Clinical Research Center for Digestive Diseases
2024
Hwa Chong Institution
2023
Tianjin University of Commerce
2022-2023
Hebei University of Technology
2023
Jiangsu University of Science and Technology
2023
Flavonoids participate in several plant processes such as growth and physiological protection adverse environments. In this study, we investigated the combined effects of eCO2 cadmium (Cd)-contaminated soils on total flavonoid monomer contents leaves Robinia pseudoacacia L. seedlings. Elevated CO2, Cd, eCO2+ Cd increased flavonoids relative to control, mostly (p < 0.05) content under exposure. CO2 robinin, rutin, acacetin 45-day seedlings decreased robinin at 90 135 d exposure except for day...
Based on the structure of caerulomycin A, 90 novel bipyridine derivatives were designed and synthesized. Among these, compound B19 exerted strong antitumor effects in vivo vitro. Importantly, NOP2/Sun RNA methyltransferase 3 (NSUN3) protein was identified as target specific binding to B19, which inhibits oxidative phosphorylation mitochondrial energy metabolism enhances glycolytic activity by NSUN3. Knockdown NSUN3 inhibited both proliferation migration colorectal cancer (CRC) cells...
Background A measles outbreak occurred in a western county of China 2013, the year after China's historic nadir measles. We conducted field investigation to identify gaps vaccination coverage and immunization program weaknesses, provide recommendations for response improvement. Methods analyzed surveillance data from 2008 2013 describe epidemiology county. Measles-containing vaccine was estimated using two methods: previously-reported administrative an estimation by clinic-kept records (n =...
This study aimed to determine whether modulation of the gut microbiota structure by liraglutide helps improve nonalcoholic fatty liver disease (NAFLD) in rats on a high-fat diet (HFD). Rats were administered an HFD for 12 weeks induce NAFLD and then 4 additional weeks. Next-generation sequencing multivariate analysis performed assess structural changes microbiota. Liraglutide attenuated excessive hepatic ectopic fat deposition, maintained intestinal barrier integrity, alleviated metabolic...
Accurate load forecasting is conducive to the formulation of power generation plan, lays foundation for quotation, and provides basis management system distribution system. This study aims propose a high precision method. The model, based on Improved Seagull Optimization Algorithm, which optimizes SVM (ISOA-SVM), constructed. First, aiming at problem that random selection internal parameters will affect its performance, Algorithm (ISOA) used optimize parameters. Second, solve slow...
Endemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children 2010. In 2011, almost half the 9943 cases China occurred eligible for vaccination. We conducted a case-control study during 2012–2013 to identify risk factors infection aged 8 months–14 years. Children with laboratory-confirmed were age- neighborhood-matched three controls. interviewed parents case control infants on...
Compare immune persistence from one dose of each 3 different hepatitis A vaccines when given to school-age children: a domestic, live attenuated vaccine (H2 vaccine); domestic inactivated (Healive®); and an imported, (Havrix®),.
We compared the efficacy and safety of beinaglutide, a glucagon-like peptide-1 (GLP-1) analogue with metformin in lowering bodyweight patients who were overweight/obese non-diabetic.Seventy-eight non-diabetic randomly selected beinaglutide or was administered for 12 weeks. The primary endpoints changes body weight proportions lost≥5 and≥10% their baseline weights.A total 64 completed study; group exhibited more loss than those [(9.5±0.8%; 9.1±0.9 kg) (5.1±0.9%; 4.5±0.8 kg), respectively,...
Primary bone tumor resections often result in critical size defects, which then necessitate challenging clinical management approaches to reconstruct. One such intervention is the Masquelet technique, poly(methyl methacrylate) (PMMA) cement placed as a spacer temporarily while adjuvant chemotherapeutics are administered systemically. The later removed and replaced with autograft. Local recurrence remains an important devastating problem, therefore, system capable of locally delivering will...
The recommendation model based on the knowledge graph (KG) alleviates problem of data sparsity in to a certain extent and further improves accuracy, diversity, interpretability recommendations. Therefore, has become major research topic, question how utilize entity relation information fully effectively KG focus research. This paper proposes adversarial training (ATKGRM), which can dynamically adaptively adjust aggregation weight learn features users items more reasonably. First, generator...
Understanding how the host immune system engages complex pathogens is essential to developing therapeutic strategies overcome their virulence. While granzymes are well understood trigger apoptosis in infected cells or bacteria, less known about mobilizes individual granzyme species vivo combat diverse pathogens. Toward goal of studying function directly vivo, we previously developed a new class radiopharmaceuticals termed "restricted interaction peptides (RIPs)" that detect biochemically...
HDAC8 is a therapeutic target with great promise for breast cancer. Here, we reported novel compound corallorazine D from
Triple-negative breast cancer (TNBC) represents a highly aggressive and heterogeneous malignancy. Currently, multitarget drug approaches present promising therapeutic approach for TNBC. Utilizing combinatorial chemistry strategy to construct virtual screening database, dual ROCK/HDAC-targeting benzothiophene compounds were identified. Notably, compound
Introduction: Wheat bran is the main by-product of wheat processing, containing about 30% pentosan and 0.4%-0.7% ferulic acid. raw material used to prepare feruloyl oligosaccharides by hydrolysis Xylanase, we discovered that ability Xylanase hydrolyze could be affected in presence different metal ions. Methods: In present study, have probed effects ions on activity tried analyze effect Mn2+ molecular dynamic (MD) simulation. Results: Our results suggested had improved hydrolyzing obtain...
While periprosthetic joint infections (PJIs) result in a small percentage of patients following arthroplasties, they are challenging to treat if spread into bone and soft tissue. Treatment involves delivering antibiotics using poly(methyl methacrylate) (PMMA) cement. However, antibiotic release is insufficient for prolonged infections. Previous work demonstrated efficacy incorporating insoluble cyclodextrin (CD) microparticles PMMA improve allow post-implantation drug refilling occur...
The existence of benefit distribution unfairness may lead to problems such as resettlement conflicts, which have become the bottleneck sustainable development water resources in many countries. Exploring and establishing equitable sharing systems are resolving approach, but there is still lack quantitative analysis tools for distribution. From perspective sharing, this study designs specific methods determine land compensation prices that migrants deserve makes a case two projects China....
Abstract A novel staurosporine derivate, streptomholyrine ( 1 ), along with 6 known compounds were identified from the rice‐based solid fermentation of marine‐derived Streptomyces sp. ZS‐A121. The planar structure and absolute configuration elucidated using a combination 1D, 2D NMR, HRESIMS data analysis, chemical transformation, ECD NMR calculations. Screening all these revealed their cytotoxic activity against HCT‐116 cell lines, IC 50 values ranging 0.012 to 11.67 μ M, except for H...
Context: Alchemilla japonica is a therapeutically important medicinal plant, which widely used in traditional medicine external application for injuries as well orally acute diarrhea, dysmenorrhea, and menorrhagia, among others. However, there not correct identification of this species prime importance differentiate it from commonly available adulterants or substitutes, fresh, dried powdered state. There only small number data pharmacological standards authentication A. japonica. Aims: To...