A5036229462- Neurobiology and Insect Physiology Research
- Zebrafish Biomedical Research Applications
- Plant and animal studies
- Evolution and Science Education
- Species Distribution and Climate Change
- Marine animal studies overview
- Insect and Arachnid Ecology and Behavior
- Animal Genetics and Reproduction
- Evolution and Paleontology Studies
- Nutrition, Genetics, and Disease
- Paleontology and Evolutionary Biology
- Atrial Fibrillation Management and Outcomes
- Animal Behavior and Reproduction
- Developmental Biology and Gene Regulation
- Genetics, Bioinformatics, and Biomedical Research
- Subterranean biodiversity and taxonomy
- Marine Biology and Ecology Research
- Wildlife Ecology and Conservation
- Cardiac electrophysiology and arrhythmias
- Epigenetics and DNA Methylation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Evolution and Genetic Dynamics
- Philosophy and History of Science
- Marine Ecology and Invasive Species
- Cephalopods and Marine Biology
Ludwig-Maximilians-Universität München
1998-2025
German Centre for Cardiovascular Research
2020-2025
LMU Klinikum
2025
Kleijnen Systematic Reviews (United Kingdom)
2012-2024
Science Navigation Group (United Kingdom)
2010-2023
Max Planck Institute for Developmental Biology
1999-2016
Max Planck Society
2016
Colour patterns are a prominent feature of many animals and high evolutionary relevance. In zebrafish, the adult pigment pattern comprises alternating stripes two cell types, melanophores xanthophores. How defined straight boundary is formed remains elusive. We find that mutants lacking one type lack striped pattern. Instead, cells form characteristic by homotypic interactions. Using mosaic analysis, we show juxtaposition xanthophores suffices to restore stripe formation locally. Based on...
Large-scale mutagenesis screens in the zebrafish employing mutagen ENU have isolated several hundred mutant loci that represent putative developmental control genes. In order to realize potential of such screens, systematic genetic mapping mutations is necessary. Here we report on a large-scale effort map generated screening at Max Planck Institute for Developmental Biology by genome scanning with microsatellite markers.We selected set markers and developed methods scoring criteria suitable...
ABSTRACT Polyamines are small poly-cations essential for all cellular life. The main polyamines present in metazoans putrescine, spermidine and spermine. Their exact functions still largely unclear; however, they involved a wide variety of processes affecting cell growth, proliferation, apoptosis aging. Here we identify idefix, mutation the zebrafish gene encoding enzyme synthase, leading to severe reduction levels as shown by capillary electrophoresis-mass spectrometry. We show that...
Thrombosis and thromboembolism are serious clinical complications of cardiovascular diseases among the leading causes mortality worldwide. Dysregulation renin-angiotensin system is associated with an increased incidence thrombotic events. Angiotensin II (AngII) known to enhance platelet aggregation, contributing a prothrombotic state in patients. Important biological roles other angiotensin peptides their receptors have been shown, but specific role thrombus formation remains unclear. Recent...
Atrial fibrillation (AF) is a major healthcare challenge contributing to high morbidity and mortality. Treatment options are still limited, mainly due insufficient understanding of the underlying pathophysiology. Further research development reliable animal models resembling human disease phenotype therefore necessary develop novel, innovative ideally causal therapies. Since ischaemic heart failure (IHF) cause for AF in patients we investigated context IHF close-to-human porcine...
Like many success stories, the career of DNA as molecule heredity and icon modern biology began under somewhat less glamorous circumstances. The story begins in 1844, one hundred years before Avery his colleagues realised significance genetic material (see accompanying article), with birth Basel Friedrich Miescher, who went on to discover at age 25.