A5012218506- Antifungal resistance and susceptibility
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- T-cell and B-cell Immunology
- Fungal Infections and Studies
- Piperaceae Chemical and Biological Studies
- Asthma and respiratory diseases
- Probiotics and Fermented Foods
- Immune Cell Function and Interaction
- Nicotinic Acetylcholine Receptors Study
- Gut microbiota and health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacological Receptor Mechanisms and Effects
University College London
2023
King's College London
2019-2022
The Francis Crick Institute
2019-2022
Candida albicans is a fungal pathobiont, able to cause epithelial cell damage and immune activation. These functions have been attributed its secreted toxin, candidalysin, though the molecular mechanisms are poorly understood. Here, we identify epidermal growth factor receptor (EGFR) as critical component of candidalysin-triggered responses. We find that both C. candidalysin activate human EGFR receptors candidalysin-deficient mutants induce phosphorylation during murine oropharyngeal...
The fungal pathogen
Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents inducers. Whilst some expressed constitutively at mucosal tissues, the primary site of many infections, others elicited in response to pathogens. In context Candida albicans, fungal factors inducing release these innate immune molecules poorly defined. Herein, we identify candidalysin a potent trigger several key AMPs known possess anti-Candida functions. We also find extracellular ATP be an...
Germinal center (GC) dysregulation has been widely reported in the context of autoimmunity. Here, we show that interleukin 21 (IL-21), archetypal follicular helper T cell (Tfh) cytokine, shapes scale and polarization spontaneous chronic autoimmune as well transient immunization-induced GC. We find IL-21 receptor deficiency results smaller GC are profoundly skewed toward a light zone B phenotype plays key role selection cells for entry to dark zone. Light skewing previously mice lacking cycle...