A5102935093- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
- Immune Cell Function and Interaction
- Alzheimer's disease research and treatments
- Trace Elements in Health
University College London
2023
The University of Texas Rio Grande Valley
2021
Germinal center (GC) dysregulation has been widely reported in the context of autoimmunity. Here, we show that interleukin 21 (IL-21), archetypal follicular helper T cell (Tfh) cytokine, shapes scale and polarization spontaneous chronic autoimmune as well transient immunization-induced GC. We find IL-21 receptor deficiency results smaller GC are profoundly skewed toward a light zone B phenotype plays key role selection cells for entry to dark zone. Light skewing previously mice lacking cycle...
Chemical synaptic transmission represents the most sophisticated dynamic process and is highly regulated with optimized neurotransmitter balance. Imbalanced transmitters can lead to impairments, for example, intracellular zinc accumulation a hallmark of degenerating neurons. However, underlying mechanisms remain elusive. Postsynaptic density protein-95 (PSD-95) primary postsynaptic membrane-associated protein major scaffolding component in excitatory densities, which performs substantial...