A5023815228- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
University College London
2022-2024
Germinal center (GC) dysregulation has been widely reported in the context of autoimmunity. Here, we show that interleukin 21 (IL-21), archetypal follicular helper T cell (Tfh) cytokine, shapes scale and polarization spontaneous chronic autoimmune as well transient immunization-induced GC. We find IL-21 receptor deficiency results smaller GC are profoundly skewed toward a light zone B phenotype plays key role selection cells for entry to dark zone. Light skewing previously mice lacking cycle...
Abstract Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback this approach impaired regulatory homeostasis that requires signaling. Therefore, strategies restrict the effects blockade cells would be advantageous. Here we probe relative roles IL-2 maintaining Treg. We find provision counteracts loss induced by while minimally affecting conventional compartment. These...
Summary Efficacy of checkpoint inhibitor therapies in cancer varies greatly, with some patients showing complete responses while others do not respond and experience progressive disease. We aimed to identify correlates response progression following PD-1-directed therapy by immunophenotyping peripheral blood samples from 20 advanced malignant melanoma before after treatment the PD-1 blocking antibody pembrolizumab. Our data reveal that individuals responding blockade were characterised...
Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including the context of tissue-damaging autoimmune or anti-viral responses. Using severe COVID-19 as a paradigm immune dysregulation, we have explored how cTfh phenotype relates to titre and quality antibody Severe was associated with higher titres neutralising S1 IgG evidence increased cell activation. ICOS, CD38 HLA-DR expressing correlated serum strength, interestingly expression TIGIT by...