A5090012613- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Endodontics and Root Canal Treatments
- Economic and Technological Developments in Russia
- Regional Economic Development and Innovation
- Dental Implant Techniques and Outcomes
- Digitalization and Economic Development in Agriculture
- Polymer Surface Interaction Studies
- Facial Trauma and Fracture Management
- Orthopedic Infections and Treatments
- Periodontal Regeneration and Treatments
- Bone health and treatments
- Additive Manufacturing and 3D Printing Technologies
- Calcium Carbonate Crystallization and Inhibition
- Ferroelectric and Piezoelectric Materials
- Agricultural Development and Policies
- Regional Development and Policy
- Cancer, Stress, Anesthesia, and Immune Response
- Medical and Biological Sciences
- biodegradable polymer synthesis and properties
- Graphene and Nanomaterials Applications
- Analytical chemistry methods development
- Surgical Sutures and Adhesives
- Inflammatory mediators and NSAID effects
P.A. Hertzen Moscow Oncology Research Institute
2014-2023
Ministry of Health of the Russian Federation
2015-2023
Lomonosov Moscow State University
2008-2021
Moscow State University
2020
Baikov Institute of Metallurgy and Materials Science
2017
Pirogov Russian National Research Medical University
2017
Medical Radiological Research Center
2016
Bioceramics are used to treat bone defects but in general do not induce formation of new bone, which is essential for regeneration process. Many aspects related bioceramics synthesis, properties and biological response that still unknown and, there a great need further development. In the most recent research efforts were aimed on creation materials from precursors apatite humans. One possible precursor octacalcium phosphate (OCP), believed only exhibit osteoconductivity possess...
Octacalcium phosphate (OCP), a new-generation bone substitute material, is considered precursor of the biological apatite. The two-layered structure OCP contains apatitic and hydrated layers intensively involved in ion-exchange surface reactions, which results hydrolysis to hydroxyapatite adsorption ions or molecular groups presented environment. During various vitro procedures, such as biomaterial solubility, additive release studies, functionalization technique, several model solutions are...
Bones are the fourth most frequent site of metastasis from malignant tumors, including breast cancer, prostate melanoma, etc. The bioavailability bone tissue for chemotherapy drugs is extremely low. This requires a search new approaches targeted drug delivery to tumor growth zone after surgery treatment. aim this work was develop method octacalcium phosphate (OCP) graft functionalization with cytostatic cisplatin provide local release its therapeutic concentrations into defect. OCP porous...
Recent approaches to the calcium phosphate (CaP) materials functionalization with drugs and biomolecules have been actively developed for bone defect reconstruction. However, current techniques are low efficient in context of drug incorporation non-controlled release from materials. Eventually, continuous therapeutic effect area couldn’t be achieved. The aim this work was develop an effective method biologically active molecules onto surface CаP materials, study dynamics its release....
The biomimetic precipitation of calcium phosphate (CaP) coating was performed by soaking β-tricalcium (TCP) ceramic scaffolds in supersaturated solution. Surface functionalization obtained incorporation bovine serum albumin (BSA) as a model protein. structure and phase composition were studied application XRD, FTIR, SEM, BET absorption. BSA content result co-precipitation evaluated.
The concept of functionalization with bioactive molecules and drugs is one the most advanced areas modern bone tissue biomaterial science in terms enhancement their osteoconductive therapeutic properties. purpose this study was to develop approaches for 3D printing sodium alginate /gelatin /octacalcium phosphate-based constructs antibacterial antitumor activity intended defects replacement patients malignant diseases. In work, we evaluated drug release kinetic physicochemical characteristics...
In the current difficult business conditions in Russian Federation, due to restrictive measures of unfriendly countries towards economy, there is a growing need for mechanisms effectively increase resilience agricultural systems sanctions risks, trade barriers and other external threats, reinforced by low sovereignty country’s food potential. this context, significant adaptive potential concentrated transformation processes economic entities that are producers products food, taking into...
Porous granular composite biomaterials based on sodium alginate and calcium phosphate component: 1% alginate; with gelatin (80/20); ceramics (CHA, TCP OCP) materials alginate/CHA, alginate/TCP, alginate/OCP, alginate/gelatin (80/20)/TCP alginate/TCP/CHA/OCP were investigated for cytotoxicity matrix (for cells) properties in dynamics of cultivation (up to 21 days). Two adhesive cell lines - immortalized human fibroblasts (HF, strain 1608 hTERT) osteosarcoma (MG-63) used vitro MTT assay. OCP...
Bone extracellular matrix comprises a unique composite compound including the mineral and organic components. Therefore, use of biomimetic approach to formation tissue-engineered constructions for bone defects replacement based on materials containing biopolymers calcium phosphates, as expected, can significantly improve their cyto-, biocompatibility osteoplastic properties. The aim work was study structural features, properties 3D-constructions sodium alginate, gelatin, two types phosphates...
Introduction. The local delivery of therapeutic antibiotic concentrations to the zone surgical intervention in bone pathology enables either prevent or significantly decrease rate osteomyelitis development. It that study efficacy vancomycin inclusion and release from three dimensional constructors based on sodium alginate, gelatin octacalcium phosphate intended for defect substitution was studied. Materials methods . Prototyping 3D performed by extrusion printing. Various were added as an...
Abstract Methods of quantitative determination the platinum content in high-salt solutions have been developed using atomic absorption spectroscopy (AAS). Definitions were carried out for small volume bioassays during research functionalization calcium phosphate substitute materials with anticancer drug, cisplatin. The conditions Pt flame optimized. effects cisplatin matrix solutions, salt components and concentrations on value found out. relevance application version AAS method was shown...
Due to the lack of entrepreneurial activity in many regions theRussian Federation, limited investment resources, which have become especially acute due pandemic, objective assessment as a basis for developing an effective program support entrepreneurship each region becomes particularly relevant and practical. The goal paper is development methodological instrumental approaches solving problem quantitative business based on comparison number indicators. This article offers approach complex...
В статье проведена количественная оценка социально-экономического потенциала территорий опережающего развития (ТОР) регионов Дальневосточного федерального округа (ДФО). Рассматриваются ключевые показатели ТОР ДФО, определен их вклад в динамику инвестиций основной капитал и занятости выделены группы ДФО по степени влияния на параметры социального, экономического инвестиционного развития, проанализирована отраслевая специализация ТОР, вклада инвестиции занятость экономике до 2024 г.