A5100663726- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Medical Imaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Radiomics and Machine Learning in Medical Imaging
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Influenza Virus Research Studies
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- Cytomegalovirus and herpesvirus research
- Vector-Borne Animal Diseases
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
Shanghai First People's Hospital
2025
Shanghai Jiao Tong University
2025
Jinan University
2024
Fudan University
2013-2023
Shandong First Medical University
2010-2023
Mississippi State University
2023
Jiangsu Provincial Center for Disease Control and Prevention
2023
Northeast Forestry University
2023
Jinan Central Hospital
2023
Tianjin Medical University Cancer Institute and Hospital
2023
RORγt is a key transcription factor that controls the development and function of inflammatory Th17. The mechanisms regulate stability remain unclear. We report Th17 cells highly express deubiquitinase ubiquitin-specific protease (USP)4, which essential for maintaining cell function. Inhibition catalytic activity USP4 with vialinin A, compound derived from Chinese traditional medicine, dampened differentiation. interacted deubiquitinated K48-linked polyubiquitination RORγt, thereby promoting...
Type 2 (T2)-high asthma with neutrophilic inflammation is characterized by airway eosinophilic and infiltration, hyperresponsiveness, remodeling, insensitivity to steroid treatment. Sphingosine-1-phosphate (S1P), which has a crucial role in the development of asthma, promotes proliferation contraction smooth muscle cells (ASMCs), contributing pathophysiological processes asthma. However, downstream mediator S1P remains unclear, as does its T2-high inflammation. Ovalbumin- ozone-induced...
Diabetic nephropathy (DN) is considered the primary causes of end-stage renal disease (ESRD) and related to abnormal glycolipid metabolism, hemodynamic abnormalities, oxidative stress chronic inflammation. Antagonism vascular endothelial growth factor B (VEGF-B) could efficiently ameliorate DN by reducing lipotoxicity. However, this pharmacological strategy far from satisfactory, as it ignores numerous pathogenic factors, including anomalous reactive oxygen species (ROS) generation...
The pathogenesis of diabetic kidney disease (DKD) is complicated. Current clinical treatments fail to achieve satisfactory efficacy in the prevention DKD progression, it urgently needs novel and effective treatment for DKD. In this study, we firstly demonstrated that renal lipid metabolism abnormality inflammation significantly changed conditions by mining public transcriptomic data patient samples. KEGG analysis further exhibited critical role vascular endothelial growth factor B (VEGF-B)...
Abstract T helper 17 (Th17) cells not only play critical roles in protecting against bacterial and fungal infections but are also involved the pathogenesis of autoimmune diseases. The retinoic acid-related orphan receptor (RORγt) is a key transcription factor Th17 cell differentiation through direct transcriptional activation interleukin 17(A) (IL-17). How RORγt itself regulated remains unclear. Here, we report that p300, which has histone acetyltransferase (HAT) activity, interacts with...
To investigate the specificity, sensitivity, and concomitant presence of antibodies against histones (H), histone H1 (H1), H3 (H3) in patients with systemic lupus erythematosus (SLE) analyze their association SLE. Serum IgG anti-histones were detected by enzyme-linked immunosorbent assay 144 SLE consisting 24 neuropsychiatric (NPSLE), 65 nephritis (LN), 55 SLE, 100 other rheumatic diseases patients, as well 40 healthy controls. Clinical biological parameters also evaluated. Anti-H, anti-H1,...
Polymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies. Genetic variability in human leukocyte antigen (HLA) genes plays an important role the pathogenesis of PM DM. However, few studies on subject Chinese populations have been reported thus far. We studied influence HLA polymorphisms DM susceptibility by analyzing HLA-DRB1, HLA-DQA1, HLA-DQB1 alleles 71 adult patients, 20 113 controls a Han population. A positive association was found between HLA-DQA1*0104 (p =...
Objective Knee osteoarthritis (KOA) is a degenerative joint condition, leading to disability and diminished quality of life. Molecular hydrogen has been proven have antioxidant anti-inflammatory properties, but few studies investigated its effects on osteoarthritis. Our study aims assess the therapeutic potential hydrogen-oxygen mixture (H 2 -O ) inhalation for KOA. Methods In this randomized controlled trial, eligible elderly KOA patients were randomly assigned either Group H or C. Both...
An enzyme-linked immunosorbent assay (ELISA) using recombinant nucleoprotein (rNP) was reported for the detection of immunoglobulin G (IgG) antibodies to Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV). The M (IgM)-capture ELISA developed diagnosis CCHFV infections, rNP as an antigen. These newly assays were applied a study CCHF-outbreak and evaluated with sera collected from patients diagnosed having CCHF by positive reverse transcription-polymerase chain reaction (RT-PCR) IgG...
ABSTRACT In order to study the effective mechanism of a traditional Chinese medicine (TCM), modified Jiu Wei Qiang Huo decoction (MJWQH), against H1N1‐induced pneumonia in mice, we chose holistic approach. A reverse‐phase liquid chromatography with quadruple time‐of‐flight mass spectrometry (LC‐Q‐TOF‐MS) was developed determine metabolomic biomarkers mouse serum for MJWQH effects. Thirteen mice were identified, which comprised l ‐valine, lauroylcarnitine, palmitoyl‐ ‐carnitine, ‐ornithine,...
Leptin is a cytokine‑like hormone secreted by adipocytes, which serves to control energy expenditure and metabolism. In addition, leptin may modulate the innate adaptive immune responses. The cell sensor nucleotide‑binding oligomerization domain‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome mainly expressed in myeloid cells, including macrophages. NLRP3 pivotal role development maintenance of autoimmunity inflammation. expression levels caspase‑1, apoptosis‑associated...
The case of a child with Crimean-Congo hemorrhagic fever (CCHF) presumably infected CCHF virus from her 27-year-old mother is described. was treated ribavirin and did not present any symptoms obvious hemorrhage. developed on the 5th day after mother's onset. partial genome amplified by RT-PCR, nested PCR sequence were identical to that mother, indicating possible transmission child. This indicates importance preventive measures for in-house outbreaks CCHF.
Background This study aimed to evaluate autoantibodies against the native ribosomal P complex (anti‐Rib‐P C ) and recombinant proteins (anti‐Rib‐P0, anti‐Rib‐P1, anti‐Rib‐P2) for their prevalence, diagnostic relevance clinical associations in a Chinese cohort with systemic lupus erythematosus (SLE). Methods Anti‐Rib‐P, anti‐dsDNA anti‐Smith antigen (Sm) antibodies were analyzed sera from 198 patients SLE, 33 rheumatoid arthritis, 61 Sjögren's syndrome 70 healthy individuals by means of...
Although elevated serum IgE levels have been reported in psoriasis, the role of psoriasis still needs to be clarified.To analyse total addition presence and distribution FcεRI psoriatic lesions, investigate alteration after successful systemic treatment.Total were determined using enzyme-linked immunosorbent assay. The expression localization was investigated immunohistochemistry double immunofluorescence.Elevated found 39% patients with psoriasis. significantly higher male compared female...
Background Psoriasis is a chronic, relapsing, inflammatory skin disease, in which regulatory T cells (Tregs) play an important role. Recently, human Treg ectoenzymes (CD39/CD73) have been reported to mediate the suppressive activity of Tregs. Aim To investigate proportions CD39/CD73 expressing Foxp3+ different types psoriatic lesions. Methods Immunohistochemical staining was used analyse expression Foxp3, CD39 and CD73 biopsy tissue from healthy controls patients with psoriasis. Results In...
Which helper CD4+ T cell subset contributes to autoantibodies generation and severity of end-organ involvement in lupus patients remains be explored. Our research aims investigate the roles circulating Tfh (cTfh) subsets corresponding CXCR5- Th cells their correlation with SLE disease activity index 2000 (SLEDAI).Peripheral blood mononuclear (PBMCs) were isolated from systemic erythematosus (SLE) as well healthy donors. The proportion classified surface markers (CD45RO, CXCR5, CXCR3, CCR6,...