A5106186118- SARS-CoV-2 and COVID-19 Research
- Gout, Hyperuricemia, Uric Acid
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- Chronic Kidney Disease and Diabetes
Hubei University of Chinese Medicine
2024
Evolution of SARS-CoV-2 variants emphasizes the need for multivalent vaccines capable simultaneously targeting multiple strains. SCTV01E is a tetravalent COVID-19 vaccine derived from spike protein Alpha, Beta, Delta, and Omicron BA.1. In this double-blinded placebo-controlled pivotal efficacy trial (NCT05308576), primary endpoint was (VE) against seven days post-vaccination in individuals without recent infection. Other endpoints included evaluating safety, immunogenicity, VE all infections...
Objectives In this study, the efficacy of and mechanism Qingrekasen Granules (QRKSG) is evaluated by metabolomics transcriptomics using adriamycin (ADR)-induced nephrotic syndrome (NS) in rat model. Methods The model, benazepril, QRKSG group received a single injection 6.5 mg/kg ADR via tail vein rats. untreated an equal saline injection. administration drugs gavage began after completing modeling for one week. Benazepril was given at 0.9 mg/kg/d to benazepril 1.62 g/kg/d group. During...