A5103194761- Covalent Organic Framework Applications
- Advanced Photocatalysis Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Electrocatalysts for Energy Conversion
- CO2 Reduction Techniques and Catalysts
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Machine Learning in Bioinformatics
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Immunodeficiency and Autoimmune Disorders
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Oxidative Organic Chemistry Reactions
- Kawasaki Disease and Coronary Complications
- Genomic variations and chromosomal abnormalities
- Nanocomposite Films for Food Packaging
- Supramolecular Chemistry and Complexes
- Cancer Cells and Metastasis
South China Normal University
2022-2025
South China University of Technology
2023-2025
Guangdong Academy of Medical Sciences
2023-2025
Southern Medical University
2023-2025
Guangdong Provincial People's Hospital
2023-2025
Oslo University Hospital
2014-2024
University of Oslo
2011-2024
657 Oslo
2021
In this work, we innovatively assembled two types of traditional photosensitizers, that is pyridine ruthenium/ferrum (Ru(bpy)32+ /Fe(bpy)32+ ) and porphyrin/metalloporphyrin complex (2HPor/ZnPor) by covalent linkage to get a series dual photosensitizer-based three-dimensional metal-covalent organic frameworks (3D MCOFs), which behaved strong visible light-absorbing ability, efficient electron transfer suitable band gap for highly photocatalytic hydrogen (H2 evolution. Rubpy-ZnPor COF...
Covalent organic frameworks (COFs), with the features of flexible structure regulation and easy introduction functional groups, have aroused broad interest in field photocatalysis. However, due to low light absorption intensity, photoelectron conversion efficiency, lack suitable active sites, it remains a great challenge achieve efficient photocatalytic aerobic oxidation reactions. Herein, based on reticular chemistry, we rationally designed series three-motif molecular junction type COFs,...
Electrocatalytic CO2 reduction (ECR) to high value-added chemicals by using renewable electricity presents a promising strategy realize "carbon neutrality". However, the ECR system is still limited its low current density and poor utilization efficiency. Herein, confinement effect of covalent organic frameworks (COFs) confine in-situ growth metal nanoclusters (NCs), we develop series Cu NCs encapsulated on COF catalysts ([email protected]) for ECR. Among them, [email protected] as gas...
The high local electron density and efficient charge carrier separation are two important factors to affect photocatalytic activity, especially for the CO2 photoreduction reaction. However, systematic studies on structure-functional relationship regarding above based precisely structure model rarely reported. Herein, as a proof-of-concept, we developed new strategy evaluation of by controlling relative electron-deficient (ED) electron-rich (ER) intensity monomer at molecular level three...
The connectivity (valency) of building blocks for constructing 3D covalent organic frameworks (COFs) has long been limited to 4, 6, 8, and 12. Developing a higher remains great challenge in the field COF structural design. Herein, this work reports hierarchical expansion strategy making 16-connected construct COFs with sqc topology. [16 + 2] construction achieved by condensation between carbazolyl dicyanobenzene-based block (CzTPN) linear diamino linkers (BD or Bpy) affords two (named CzBD...
In this work, a series of new crystalline three‐dimensional covalent organic frameworks (3D COFs) based on [8+4] construction was designed and successfully realized efficient photocatalytic acetylene (C2H2) hydrogenation to ethylene (C2H4). By regulating the hydrogen‐localization transfer effect in these 3D COFs，the Cz‐Co‐COF‐H containing cobalt glyoximate active centers exhibited excellent C2H2‐to‐C2H4 performance, with an average C2H4 yield 1755.33 μmol g‐1 h‐1 pure C2H2, also showed near...
In this work, a series of new crystalline three‐dimensional covalent organic frameworks (3D COFs) based on [8+4] construction was designed and successfully realized efficient photocatalytic acetylene (C2H2) hydrogenation to ethylene (C2H4). By regulating the hydrogen‐localization transfer effect in these 3D COFs，the Cz‐Co‐COF‐H containing cobalt glyoximate active centers exhibited excellent C2H2‐to‐C2H4 performance, with an average C2H4 yield 1755.33 μmol g‐1 h‐1 pure C2H2, also showed near...
The oxidation resistance gene 1 (OXR1) prevents oxidative stress-induced cell death by an unknown pathway. Here, depletion of human OXR1 (hOXR1) sensitized several lines to hydrogen peroxide-induced stress, reduced mtDNA integrity, and increased apoptosis. In contrast, hOXR1 in cells lacking showed no significant change ROS or viability, suggesting that intracellular increase stress levels avoid a vicious cycle damage formation. Furthermore, expression p21 the antioxidant genes GPX2 HO-1 was...
Abstract As hot topics in the chemical conversion of CO 2 , photo‐/electrocatalytic reduction and use as a supporter for energy storage have shown great potential utilization . However, many obstacles still exist on road to realizing highly efficient conversion, such inefficient uptake/activation mass transport catalysts. Covalent organic frameworks (COFs), kind porous material, been widely explored catalysts owing their unique features. In particular, COF‐based functional materials...
Abstract The oxidation resistance gene 1 ( OXR1 ) is crucial for protecting against oxidative stress; however, its molecular function unknown. We employed RNA sequencing to examine the role of human genome wide transcription regulation. In total, in non-treated and hydrogen peroxide exposed HeLa cells, depletion resulted down-regulation 554 genes up-regulation 253 genes. These differentially expressed include factors (i.e. HIF1A , SP6, E2F8 TCF3 ), antioxidant PRDX4 PTGS1 CYGB numerous p53...
Recessive loss of function the neuronal ubiquitin hydrolase UCHL1 has been implicated in early-onset progressive neurodegeneration (MIM no. 615491), so far only one family. In this study a second family is characterized, and functional consequences identified mutations are explored. Three siblings developed childhood-onset optic atrophy, followed by spasticity ataxia. Whole exome sequencing compound heterozygous variants UCHL1, c.533G > A (p.Arg178Gln) c.647C (p.Ala216Asp), cosegregating...
The epidermal growth factor receptor mutant (EGFRm) non-small cell lung cancer (NSCLC) has a unique "cold" immune profile. DNA damage repair (DDR) genes are closely related to tumorigenesis and the effectiveness of immunotherapy in many tumors. However, role mechanism DDR genesis progression EGFRm NSCLC remain unclear. This study included 101 samples from Cancer Genome Atlas (TCGA) dataset GSE31210 (external set) GEO database. Cluster analysis was used identify different subtypes based on...
As an important branch of the covalent organic frameworks (COFs) family, one‐dimensional COFs (1D COFs) which formed by ordered arrangement confined bonds in one dimension and non‐covalent interactions (van der Waals force, π‐π hydrogen bonds, etc.) vertical two three dimensions has aroused much attention. Compared with 2D/3D COFs, 1D behaved more easily dispersing had opportunities for active sites exposure due to their weaker interchain/interlayer interaction, modified nonlinear edge, pore...
Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A-/-) develop fatty liver. RNA sequencing of Oxr1A-/- liver indicates decreased growth hormone (GH) signaling, which is known to affect metabolism. Indeed, Gh expression reduced in pituitary gland and rat adenoma cell-line GH3. show fasting-blood GH levels. Pull-down proximity ligation assays reveal OXR1A associated arginine methyl transferase PRMT5....
An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function following MI, in mice deficient NLRP3 inflammasome, can recapitulated wild-type receiving bone marrow from Nlrp3−/− mice. suggests activation hematopoietic cells infiltrating myocardium increases mortality late ventricular Our data should encourage performing clinical trials...
Abstract In this work, we innovatively assembled two types of traditional photosensitizers, that is pyridine ruthenium/ferrum (Ru(bpy) 3 2+ /Fe(bpy) ) and porphyrin/metalloporphyrin complex (2HPor/ZnPor) by covalent linkage to get a series dual photosensitizer‐based three‐dimensional metal‐covalent organic frameworks (3D MCOFs), which behaved strong visible light‐absorbing ability, efficient electron transfer suitable band gap for highly photocatalytic hydrogen (H 2 evolution. Rubpy‐ZnPor...
Antibiotic resistance is an emerging threat to public health. The development of a new generation antimicrobial compounds therefore currently required. Here we report novel polymer chitosan/polypropylene carbonate nanoparticles (CS/PPC NPs). These were designed and synthesized from readily available chitosan reactive oligomer polypropylene (PPC)-derived epoxy intermediate. By employing simple efficient functionalized strategy, series micelle-like chitosan-graft-polypropylene (CS-g-PPC)...
Hydrogenases are attractive biocatalysts for utilization in electrochemical devices as potential replacement Pt hydrogen evolving electrodes. In this work, we investigate the immobilization of ferredoxin tagged FeFe-hydrogenase (Fd-HydA1) on black TiO2 nanotubes (bTNTs), with uniform nanotube opening diameters 140 nm. By utilizing an immunogold labelling method, show that enzymes attach top surface bTNTs film rather than inner walls, reflecting difficulty to insert into high aspect-ratio...