A5101649528- Web and Library Services
- Mobile Learning in Education
- Mobile and Web Applications
- Receptor Mechanisms and Signaling
- Library Science and Administration
- Photoreceptor and optogenetics research
- Library Science and Information Literacy
- Library Collection Development and Digital Resources
- Parasites and Host Interactions
- Open Education and E-Learning
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Monoclonal and Polyclonal Antibodies Research
- Urban and Rural Development Challenges
- Helminth infection and control
- Water Quality Monitoring Technologies
- Nematode management and characterization studies
- COVID-19 Digital Contact Tracing
- Digital Humanities and Scholarship
- Digital Games and Media
- RNA and protein synthesis mechanisms
- Child Development and Digital Technology
- Studies on Chitinases and Chitosanases
- COVID-19 diagnosis using AI
- Academic Writing and Publishing
University of Virginia
2025
Bayer (United States)
2021-2023
Rice University
2023
University of Northern Colorado
2015-2021
School of the Museum of Fine Arts
2020
Washington University in St. Louis
2007-2018
St. Paul's Hospital
2016
George Mason University
2015
Endocyte (United States)
2015
Institute of Molecular Biology and Biophysics
2011
Richard Wilson and colleagues report the genome sequence of Trichinella spiralis, a food-borne parasitic nematode that diverged early in evolution phylum Nematoda. T. spiralis is most common cause human trichinellosis. Genome studies for Nematoda have been limited by focusing on comparisons involving Caenorhabditis elegans. We draft zoonotic parasite, which This an extant member clade phylum, enabling identification archetypical genes molecular signatures exclusive to nematodes. sequenced...
In Vancouver, Canada, there has been a continuous shift in the policing of sex work away from arresting workers, which led to implementation strategy that explicitly prioritised safety workers and continued target workers' clients. We conducted semi-structured interviews with 26 cisgender five transgender women street-based about their working conditions. Data were analysed thematically by drawing on concepts structural stigma vulnerability. Our results indicated despite police rhetoric...
Parasitic roundworm infections plague more than 2 billion people (1/3 of humanity) and cause drastic losses in crops livestock. New anthelmintic drugs are urgently needed as new drug resistance environmental concerns arise. A "chokepoint reaction" is defined a reaction that either consumes unique substrate or produces product. chokepoint analysis provides systematic method identifying novel potential targets. Chokepoint enzymes were identified the genomes 10 nematode species, intersection...
Contemplative practices support transformative learning processes but can be difficult to identify in a higher education environment. Advocates of contemplative approaches see this void as concern. When topics like these are ignored, especially when desired by students, staff, and faculty, the holistic, transformative, deep needs students unfulfilled. Attention brought connections between pursuit education. In qualitative study, 17 professionals were asked how they integrate into their work...
As one of the largest protein families, kinases (PKs) regulate nearly all processes within cell and are considered important drug targets. Much research has been conducted on inhibitors for PKs, leading to a wealth compounds that target PKs have potential be lead anthelmintic drugs. Identifying already developed treat neglected tropical diseases is an attractive way obtain inexpensively can into much needed drugs, especially use in developing countries. In this study, from nematodes, hosts,...
ABSTRACT Elementary science education, particularly in the 4th and 5th grades, is essential for setting foundation lifelong learning, fostering critical thinking, preparing students success science, technology, engineering, mathematics (STEM) fields. This stage especially with disabilities, as achievement gaps between them their peers emerge during elementary school. Despite this importance, little known about how taught classrooms these years, disabilities. To address gap, we surveyed...
The Bcr oligomerization domain, from the Bcr-Abl oncoprotein, is an attractive therapeutic target for treating leukemias because it required cellular transformation. domain homodimerizes via antiparallel coiled coil with adjacent short, helical swap domain. Inspection of coiled-coil sequence does not reveal obvious determinants helix-orientation specificity, raising possibility that orientation preference and/or dimeric state are due to interactions domains. To better understand how...
Abstract This study presents the results of a de novo approach modeling possible conformational dynamics extracellular (EC) loops in G‐protein‐coupled receptors (GPCRs), specifically bovine rhodopsin (bRh), squid (sRh), human β‐2 adrenergic receptor (β2AR), turkey β‐1 (β1AR), and A2 adenosine (A2AR). The deliberately sacrificed detailed description any particular 3D structure GPCRs favor less precise many structures. Despite this, found ensembles low‐energy conformers EC that contained...
Finding new drug targets for pathogenic infections would be of great utility humanity, as there is a large need to develop drugs fight due the developing resistance and side effects current treatments. Current pathogen involve only single protein. However, proteins rarely act in isolation, majority biological processes occur via interactions with other proteins, so protein-protein (PPIs) offer realm unexplored potential are thought next-generation targets. Parasitic worms were chosen this...
In recent years, two methods have been developed that may eventually allow the targeted regulation of a broad repertoire genes. The engineered protein strategy involves selecting Cys2His2 zinc finger proteins will recognize specific sites in major groove DNA. small molecule approach utilizes pairing rules for pyrrole−imidazole polyamides target minor groove. To understand how these might complement each other, we begun exploring and fingers interact when they bind same site on opposite...
Modulation of interactions between activated GPCRs (G-protein coupled receptors) and the intracellular (IC) signal transducers, heterotrimeric G-proteins, is an attractive, yet essentially unexplored, paradigm for treatment certain diseases. Regulating downstream signaling congenital diseases due to constitutively active GPCRs, as well tumors where are often overexpressed, requires development new methodologies. Modeling, experimental data, docking, scoring, testing (MEDSET) was developed...
A vast majority of the burden from neglected tropical diseases result helminth infections (nematodes and platyhelminthes). Parasitic helminthes infect over 2 billion, exerting a high collective that rivals high-mortality conditions such as AIDS or malaria, cause devastation to crops livestock. The challenges improve control parasitic are multi-fold no single category approaches will meet them all. New information genomics, functional genomics proteomics coupled with innovative bioinformatic...
Obtaining a reliable 3D model for the complex formed by photoactivated rhodopsin (R*) and its G-protein, transducin (Gtalphabetagamma), would significantly benefit entire field of structural biology G-protein-coupled receptors (GPCRs). In this study, we have performed extensive configurational sampling isolated C-terminal fragment alpha-subunit transducin, Gtalpha 340-350, within cavities different energetically feasible conformations intracellular loops. Our results suggested new...
The heterotrimeric G-protein binding site on coupled receptors remains relatively unexplored regarding its potential as a new target of therapeutic intervention or secondary action by the existing drugs. Tauroursodeoxycholic acid bears structural resemblance to several compounds that were previously identified specifically bind light-activated form visual receptor rhodopsin and inhibit activation transducin. We show TUDCA stabilizes active rhodopsin, metarhodopsin II, does not display...
G-protein coupled receptors play an essential role in many biological processes. Despite increase the number of solved X-ray crystal structures receptors, capturing a receptor its activated state for structural analysis has proven to be difficult. An unexplored paradigm is stabilization one or more conformational states via binding small molecule intracellular loops. A short tetrazole peptidomimetic based on photoactivated rhodopsin-bound structure Gt(alpha)(340-350) was previously designed...
The western corn rootworm (WCR), Diabrotica virgifera LeConte, is a major maize pest in the United States causing significant economic loss. emergence of field-evolved resistant WCR to Bacillus thuringiensis (Bt) traits has prompted need discover and deploy new insecticidal proteins transgenic maize. In current study we determined crystal structure mode action (MOA) Vpb4Da2 protein (formerly known as Vip4Da2) from Bt, first identified Vpb4 with commercial level control against WCR. exhibits...
As part of an advanced doctoral course on representing qualitative research, the authors used collage to represent either who they were as researcher or research conducting. The authors, comprised professor and seven students, read about inquiry representation then participated reflexively in a lecture background collage, creation activity, gallery walk, written oral reflection each other’s collages, poster presentation at campus event, final entire process. process unfolded represented...
Powerful dynamics of change require practitioners from all disciplines to be prepared work in interdisciplinary teams, competently access health and information technologies, understand the multiple functions required for adequate healthcare provision. The University Iowa's Integrated Health Professions Program is a state-funded effort designed provide students with common educational experience enable them collaboratively underserved or rural settings. Students take part series...
Abstract EC1456, a potent folate-targeted tubulysin conjugate, is currently being evaluated in phase 1 dose escalation study patients with advanced solid tumors. To assist upcoming cancer indication selection decisions for trials, we tested EC1456 against eight patient-derived xenograft (PDX) models. Thus, was as single agent or combination standard of care (SOC) treatments two folate receptor (FR)-positive models each ovarian, endometrial, non-small cell lung (NSCLC) and triple negative...