A5021258982- Adipose Tissue and Metabolism
- Nuclear Structure and Function
- Diet and metabolism studies
- Circadian rhythm and melatonin
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Dietary Effects on Health
- Diabetes Treatment and Management
- Muscle Physiology and Disorders
- Fibroblast Growth Factor Research
- RNA and protein synthesis mechanisms
- Erythrocyte Function and Pathophysiology
- Hippo pathway signaling and YAP/TAZ
- Retinoids in leukemia and cellular processes
- Skin and Cellular Biology Research
- Spaceflight effects on biology
- Muscle metabolism and nutrition
- Regulation of Appetite and Obesity
- Exercise and Physiological Responses
- FOXO transcription factor regulation
- Light effects on plants
University of Copenhagen
2023-2024
Karolinska Institutet
2019-2024
Novo Nordisk Foundation
2023-2024
Inserm
2013-2017
Institut du Thorax
2013-2017
Nantes Université
2013-2017
Centre National de la Recherche Scientifique
2016-2017
The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment activation. Conversely, zebrafish larvae deficient for are protected from ROS-induced pathology. Livers mice fed ROS-generating diet exhibit ZAKα-activating changes elongation dynamics....
Type 2 diabetes mellitus (T2DM) is a well-recognized independent risk factor for heart failure. T2DM associated with altered cardiac energy metabolism, leading to ectopic lipid accumulation and glucose overload, the exact contribution of these two parameters remaining unclear. To provide new insight into mechanism driving development diabetic cardiomyopathy, we studied unique model T2DM: lipodystrophic Bscl2−/− (seipin knockout [SKO]) mice. Echocardiography magnetic resonance imaging...
Rat L6, mouse C2C12, and primary human skeletal muscle cells (HSMCs) are commonly used to study biological processes in muscle, experimental data on these models abundant. However, consistently matched scarce, comparisons between the different cell types adult tissue problematic. We hypothesized that metabolic differences cellular may be reflected at mRNA level. Publicly available sets were profile levels myotubes tissues. HSMC assessed for proliferation, glucose uptake, glycogen synthesis,...
Disturbances in daily rhythms of mitochondrial activity may contribute to skeletal muscle insulin resistance type 2 diabetes.
The combination of decreasing food intake and increasing energy expenditure represents a powerful strategy for counteracting cardiometabolic diseases such as obesity type 2 diabetes1. Yet current pharmacological approaches require conjugation multiple receptor agonists to achieve both effects2–4, so far, no safe energy-expending option has reached the clinic. Here we show that activation neurokinin (NK2R) is sufficient suppress appetite centrally increase peripherally. We focused on NK2R...
The circadian clock is a cell-autonomous transcription–translation feedback mechanism that anticipates and adapts physiology behavior to different phases of the day. A variety factors including hormones, temperature, food-intake, exercise can act on tissue-specific peripheral clocks alter expression genes influence metabolism, all in time-of-day dependent manner. aim this study was elucidate effects timing adipose tissue metabolism. We performed RNA sequencing inguinal mice immediately...
Abstract Disruption of circadian rhythmicity induced by prolonged light exposure, altered sleep patterns and shift work is associated with the development obesity related metabolic disorders, including type 2 diabetes cardiovascular diseases. White brown adipose tissue activity shows rhythmicity, daily variations in regulation processes such as lipolysis, glucose lipid uptake, adipokine secretion. The role clock energy homeostasis has raised interest clock‐related strategies to mitigate...
Dysregulation of skeletal muscle metabolism influences whole-body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes–associated alterations in the plasma metabolome directly contribute to immunometabolism subsequent development resistance. To this end, we analyzed metabolite profile identified glutamine as a key amino acid correlates inversely with BMI resistance index (HOMA-IR) men normal tolerance or diabetes. Using an vitro model human myotubes vivo...
Obesity and type 2 diabetes (T2D) are growing health challenges with unmet treatment needs. Traf2- NCK-interacting protein kinase (TNIK) is a recently identified obesity- T2D-associated gene unknown functions. We show that TNIK governs lipid glucose homeostasis in Drosophila mice. Loss of the ortholog TNIK, misshapen, altered metabolite profiles impaired de novo lipogenesis high sugar-fed larvae. Tnik knockout mice exhibited hyperlocomotor activity were protected against diet-induced fat...
Fibroblast growth factor 21 (FGF21) was shown to improve metabolic homeostasis, at least partly by controlling white adipocyte profile and adiponectin secretion. Here, we studied its effect on dysfunction in the context of Berardinelli-Seip congenital lipodystrophy (BSCL) linked seipin deficiency. Bscl2-/- mice displayed a progressive adipose tissue loss with aging as evidenced altered residual fat pads decrease plasma levels 12- vs. 4-week-old animals. Aiming prevent this impairment,...
The discovery of exercise-regulated circulatory factors has fueled interest in organ crosstalk, especially between skeletal muscle and adipose tissue, the role mediating beneficial effects exercise. We studied tissue transcriptome men women with normal glucose tolerance or type 2 diabetes following an acute exercise bout, revealing substantial exercise- time-dependent changes, sustained increase inflammatory genes diabetes. identify oncostatin-M as one most upregulated...
Abstract Loss-of-function mutations in BSCL2 are responsible for Berardinelli-Seip congenital lipodystrophy, a rare disorder characterized by near absence of adipose tissue associated with insulin resistance. Seipin-deficient ( Bscl2 −/− ) mice display an almost total loss white (WAT) residual brown (BAT). Previous cellular studies have shown that seipin deficiency alters adipocyte differentiation. In this study, we aimed to decipher the consequences BAT. Using cell-line, show knockdown had...
Summary The molecular mechanisms underlying the response to exercise and inactivity are not fully understood. We propose an innovative approach profile skeletal muscle transcriptome using 66 published datasets. Data collected from human studies of aerobic resistance exercise, including acute chronic training, were integrated meta-analysis methods ( www.metamex.eu ). Gene ontology pathway analyses reveal selective pathways activated by inactivity, versus training. identified NR4A3 as one most...
Summary Circadian rhythms are generated by an auto-regulatory feedback loop composed of transcriptional activators and repressors. Disruption circadian contributes to Type 2 diabetes (T2D) pathogenesis. We elucidated whether altered rhythmicity clock genes is associated with metabolic dysfunction in T2D. Transcriptional cycling core ARNTL, CLOCK , CRY1 NR1D1 was skeletal muscle from individuals T2D this coupled reduced number amplitude disturbed oxygen consumption. Mitochondrial were...