A5066930771- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Hormonal and reproductive studies
- Steroid Chemistry and Biochemistry
- Physiological and biochemical adaptations
- Aldose Reductase and Taurine
- Stress Responses and Cortisol
- Effects and risks of endocrine disrupting chemicals
- Adrenal Hormones and Disorders
- Pharmacogenetics and Drug Metabolism
- Enzyme Structure and Function
- Neurobiology and Insect Physiology Research
- Drug Transport and Resistance Mechanisms
- Marine Biology and Environmental Chemistry
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Amino Acid Enzymes and Metabolism
- Birth, Development, and Health
- Ichthyology and Marine Biology
- Environmental Toxicology and Ecotoxicology
- Metabolism and Genetic Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Receptor Mechanisms and Signaling
- ATP Synthase and ATPases Research
University of California, San Diego
2015-2024
Valleywise Health
2019
Arizona State University
2019
Arizona Research Center
2019
University of Arizona
1993-2019
A.T. Still University
2019
Newcastle University
2018
Institute of Structural and Molecular Biology
2014
University of Lausanne
2014
University College London
2014
A "post-polio" syndrome characterized by new neuromuscular symptoms, including muscle weakness, may develop years after recovery from acute paralytic poliomyelitis. We studied 27 patients (mean age, 50.6 years) in whom weakness developed a mean of 28.8 polio. reevaluated these during follow-up period 8.2 (range, 4.5 to 20) they were originally at the National Institutes Health. The total onset was 12.2 6 29). assessed with quantitative testing, biopsy, electromyography, and virologic...
MLN64 is a protein that highly expressed in certain breast carcinomas. The C terminus of shares significant homology with the steroidogenic acute regulatory (StAR), which plays key role steroid hormone biosynthesis by enhancing intramitochondrial translocation cholesterol to side-chain cleavage enzyme. We tested ability stimulate steroidogenesis using COS-1 cells cotransfected plasmids expressing human enzyme system and wild-type mutant proteins. Wild-type increased pregnenolone secretion...
A total of 50 major bile duct injuries after laparoscopic cholecystectomy were managed by the Duke University Hepatobiliary Service from 1990-1992. The management these complex cases is reviewed.Laparoscopic preferred method for removing gallbladder. Bile injury most feared complication new procedure.Review videotapes, pathology, and original operations reviewed retrospectively, categorized. Major biliary was defined as a recognized disruption any part extrahepatic system. Biliary leakage...
Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification this are now well-understood. In contrast, origin evolution steroid ligands remain mysterious, although is crucial for understanding emergence modern endocrine systems. Using comparative genomic approach, we analyzed complete metazoan...
Vitellogenin, an ancient animal protein, is the major yolk protein of eggs, where it used as a food source during embryogenesis. Here shown that vitellogenins, including those from invertebrates Caenorhabditis elegans and Drosophila melanogaster, contain domains are homologous with parts apolipoprotein B-100 (apoB-100) human low-density lipoprotein lipase. As vitellogenins likely to have been by embryogenesis well before circulation lipids appeared in vertebrates, suggested copies precursor...
Abstract Teleost fishes exhibit complex sexual characteristics in response to androgens, such as fin enlargement and courtship display. However, the molecular mechanisms underlying their evolutionary acquisition remain largely unknown. To address this question, we analyse medaka ( Oryzias latipes ) mutants deficient teleost-specific androgen receptor ohnologs ara arb ). We discovered that neither ar ohnolog was required for spermatogenesis, whilst they appear be functionally redundant...
Motivation:Modeling families of related biological sequences using Hidden Markov models (HMMs), although increasingly widespread, faces at least one major problem: because the complexity these mathematical models, they require a relatively large training set in order to accurately recognize given family. For which there are few known sequences, standard linear HMM contains too many parameters be trained adequately
Hepatic adenoma: MR characteristics and correlation with pathologic findings.E K Paulson, J S McClellan, Washington, C E Spritzer, W Meyers M BakerAudio Available | Share
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSite-specific mutagenesis of Drosophila alcohol dehydrogenase: Evidence for involvement tyrosine-152 and lysine-156 in catalysisZhuo Chen, James C. Jiang, Zhi Gong Lin, William R. Lee, Michael E. Baker, Simon H. ChangCite this: Biochemistry 1993, 32, 13, 3342–3346Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April...
Oxidized regenerated cellulose (Surgicel), a sterile knitted fabric that causes thrombus formation because of its physical properties, is frequently used for intraoperative hemostasis. Unlike traditional surgical sponges, it bioabsorbable and can be left in the bed. On CT scans, appearance retained oxidized mimic an abscess. The purpose this study was to describe on postoperative scans so erroneous diagnosis abscess avoided.We reviewed examinations five patients whom had been Operative...
The SLC22 family of OATs, OCTs, and OCTNs is emerging as a central hub endogenous physiology. Despite often being referred to "drug" transporters, they facilitate the movement metabolites key signaling molecules. An in-depth reanalysis supports reassignment these proteins into eight functional subgroups, with four new subgroups arising from previously defined OAT subclade: OATS1 (SLC22A6, SLC22A8, SLC22A20), OATS2 (SLC22A7), OATS3 (SLC22A11, SLC22A12, Slc22a22), OATS4 (SLC22A9, SLC22A10,...
Although the hepatotoxic effects of systemic chemotherapy are well known, CT findings in liver after have received little attention literature. In some patients with breast carcinoma metastatic to who chemotherapy, a morphologic pattern develops similar that associated cirrhosis. This is characterized by lobular hepatic contour, segmental volume loss, and enlargement caudate lobe. The purpose this study was describe appearance pseudocirrhosis correlate it pathologic findings.We reviewed 65...
Mammalian 3β‐hydroxysteroid dehydrogenase and plant dihydroflavonol reductases are descended from a common ancestor. Here we present evidence that Nocardia cholesterol dehydrogenase, E. coli UDP‐galactose‐4 epimerase, open reading frames in vaccinia virus fish lymphocystis disease homologous to dehydroflavonol reductase. Analysis of multiple alignment these sequences indicates viral ORFs most closely related the mammalian dehydrogenases. The ancestral protein this superfamily is likely be...