A5059112862- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Tracheal and airway disorders
- Neuroblastoma Research and Treatments
- Polyomavirus and related diseases
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Advanced X-ray and CT Imaging
- Cystic Fibrosis Research Advances
- Ubiquitin and proteasome pathways
- Trauma Management and Diagnosis
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Tuberous Sclerosis Complex Research
- Cancer, Hypoxia, and Metabolism
- Genetic and Kidney Cyst Diseases
- Congenital Diaphragmatic Hernia Studies
- Myasthenia Gravis and Thymoma
Instituto Maimónides de Investigación Biomédica de Córdoba
2013-2024
Hospital Dr. Gustavo Fricke
2024
University of Córdoba
2008-2023
Hospital Universitario Reina Sofía
2014-2023
Universidad Nacional de Chimborazo
2023
Sofia University "St. Kliment Ohridski"
2010
Typical carcinoids (TCs) are uncommon, slow-growing neoplasms, usually with high 5-year survival rates. As these rare tumours, their management is still based on small clinical observations and no international guidelines exist. Based the European Society of Thoracic Surgeon Neuroendocrine Tumours Working Group (NET-WG) Database, we evaluated factors that may influence TCs mortality.Using NET-WG database, an analysis TC was performed. Overall (OS) calculated starting from date intervention....
Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but largely ineffective in LSCC. The tumor suppressor FBW7 is commonly mutated or down-regulated human LSCC, oncogenic KRasG12D activation combined with Fbxw7 inactivation mice (KF model) caused both LSCC LADC. Lineage-tracing experiments showed that CC10+, not basal, cells of origin KF mice. tumors recapitulated resistance...
Airway complications (AC) remain a significant contributing factor of morbidity after lung transplantation (LT). The aim this study was to identify risk factors for AC, and review the outcomes endoscopic surgical treatment.From 1993 2006, 255 patients underwent LT. Seven retransplants 34 not surviving beyond 7 days were excluded. remaining were: 124 double LT (DLT), 85 single (SLT), 3 lobar 2 liver-DLT, comprising 343 bronchial anastomoses at risk. Donor lungs flushed with either modified...
In 2012, the European Society of Thoracic Surgeons (ESTS) created Lung Neuroendocrine Tumors Working Group (NETs-WG) with aim to develop scientific knowledge on clinical management such rare neoplasms. This paper outlines outcome and prognostic factors two aggressive NETs: atypical carcinoids (ACs) large-cell neuroendocrine carcinomas (LCNCs). Using ESTS NETs-WG database, we retrospectively collected data 261 patients in seven institutions Europe, between 1994 2011. We used a Cox regression...
Although metabolomics has attracted considerable attention in the field of lung cancer (LC) detection and management, only a very limited number works have applied it to tissues. As such, aim this study was thorough analysis metabolic profiles relevant LC tissues, including most important histological subtypes (adenocarcinoma squamous cell carcinoma). Mass spectrometry‐based metabolomics, along with genetic expression analyses, were performed as part study, widest date, identify alterations...
Primary ciliary dyskinesia, with or without situs abnormalities, is a rare lung disease that can lead to an irreversible damage may progress respiratory failure. Lung transplant be considered in end-stage disease. This study describes the outcomes of largest population for PCD and also identified as Kartagener’s syndrome. Retrospectively collected data 36 patients who underwent transplantation from 1995 2020 SA part European Society Thoracic Surgeons Transplantation Working Group on...
Abstract OBJECTIVES Typical carcinoids (TCs) are rare, slow-growing neoplasms, usually characterized by satisfactory surgical outcomes. Due to the rarity of TCs, international guidelines for management particular clinical presentations currently do not exist. In particular, non-anatomical resections (wedges) sometimes advocated Stage 1 TCs because their indolent behaviour. The aim this paper was evaluate most effective type surgery using European Society Thoracic Surgeons retrospective...
The main limitation to increased rates of lung transplantation (LT) continues be the availability suitable donors. At present, largest source allografts is still donation after neurologic determination death (brain-death donors, DBD). However, only 20% these donors provide acceptable for transplantation. One proposed strategies increase donor pool use circulatory-determination-of-death (DCD), which has potential significantly alleviate shortage transplantable lungs. According Maastricht...
In current practice, donors and recipients are not matched for gender in lung transplantation. However, some data have suggested a possible effect of combinations on transplant outcomes. We examined whether donor–recipient (D/R) mismatch is related to adverse outcomes after transplantation terms early long-term graft function survival. reviewed 256 over 14-year period. Patients were distributed into four groups: Group A (D/R: female/female), B male/male), C female/male), D male/female)....
Abstract The rich chemical information from tissue metabolomics provides a powerful means to elaborate physiology or tumor characteristics at cellular and microenvironment levels. However, the process of obtaining such requires invasive biopsies, is costly, can delay clinical patient management. Conversely, computed tomography (CT) standard care but does not intuitively harbor histological prognostic information. Furthermore, ability embed metabolome into CT subsequently use learned...
The survival benefit of lung transplantation (LTx) for cystic fibrosis (CF) patients is well demonstrated. We aim to compare children and adult CF recipients assess whether there are differences in clinical outcomes, identify risk factors mortality.A retrospective analysis 442 consecutive LTx performed at our institution a 20-year period was conducted. were distributed into two groups: (age <18 years) adults ≥18 years). Donor recipient general demographic data, perioperative postoperative...
Lung cancer is the leading cause of cancer-related deaths worldwide. Overall 5-year survival has shown little improvement over last decades. Seven in absentia homolog (SIAH) proteins are E3 ubiquitin ligases that mediate proteasomal protein degradation by poly-ubiquitination. Even though SIAH play a key role several biological processes, their human remains controversial. The aim study was to document SIAH2 expression pattern at different levels (mRNA, level and immunohistochemistry)...
This study aims to assess the suitability rates and causes of lung-donor refusal, determine which factors could be improved expand donor pool available for transplantation (LTx).Lung donors offered our Lung Transplantation Unit from October 1993 December 2007 were reviewed unsuitability. The donor-lung evaluation was divided into three stages: stage 1 (PaO(2)/FiO(2) ratio, chest X-ray, bronchoscopic findings), 2 (donor-lung inspection palpation) 3 (assessment grafts after harvesting)....
Objective To determine whether problems arising in the native lung may influence short-term outcomes and survival after single transplantation (SLT), therefore should be taken into consideration when selecting transplant procedure. Patients methods Retrospective review of 258 transplants performed between June 2012 2019. Among them, 161 SLT were selected for analysis. Complications recorded distributed two groups: early late complications (within 30 days or post-transplant). Donor recipient...
Tourism is an important sector of the industry with global influence on economy and development while change nowadays a major challenge worldwide. This study aims to present bibliometric analysis that evidences trends scientific production “tourism” “global change”, supported by visualization techniques provided VOSviewer software. A total 3519 documents were retrieved from Scopus database includes identification frequencies papers published, most influential authors, countries highest...