A5102970098- Occupational and environmental lung diseases
- Trace Elements in Health
- MicroRNA in disease regulation
- Heavy metals in environment
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Barrier Structure and Function Studies
- Immune cells in cancer
- Cancer Research and Treatments
- Diabetes Treatment and Management
- Occupational exposure and asthma
- RNA regulation and disease
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Homelessness and Social Issues
- Respiratory Support and Mechanisms
- Extracellular vesicles in disease
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
North China University of Science and Technology
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
University of Science and Technology Liaoning
2020
Abstract Silicosis is a well‐acknowledged occupational lung disease caused by inhalation of large amount free silica dust during the production period and eventually considerable negative impact on patients' quality life. Autophagy exerts critical influence immune inflammatory responses pathogenesis pulmonary fibrosis. In this study, we sought to determine whether autophagy involved in silicosis's how it may affect cellular physiology. animal experiments, found persistent activation...
Abstract Increased deposition of silica dust in pulmonary interstitial tissues leads to silicosis, which autophagy plays a defensive role dust‐associated stress response and cell death. Our previous studies revealed that exposure contributed macrophages vivo, while the specific regulatory mechanism is still unclear. This study aimed figure out as well pathogenesis experimental silicosis. We used 3‐methyladenine (3‐MA) ABT‐737 suppress expression phosphatidylinositol 3‐kinase catalytic...
Exposure to silica nanoparticles (SiNPs) is related the dysregulation of pulmonary surfactant that maintains lung stability and function. Nevertheless, there are limited studies concerning interaction influence between SiNPs surfactant, damage mechanism still unclear. Herein, we used A549 cells develop an in vitro model, with which investigated effect exposure on expression potential regulatory mechanism. The results showed were cytotoxicity regarding reduced cell viability promoted...
Exosomes can transmit central nervous system (CNS) information to the peripheral circulatory through brain barrier, and exosomes in blood also enter likewise. The components of exosomal contents play a pivotal role cell signal communication, thus, transmission content is considered as newly discovered method long-distance communication between cells. current aimed explore changes microRNA group serum lead-exposed workers, which might be involved lead-induced neuroinflammation, especially...
Abstract Parkinson's disease (PD) is one of the most common neurodegenerative movement disorders, for which there has been no effective treatments. To clarify pathogenesis PD, we constructed a competing endogenous RNA (ceRNA) network based on genome‐wide sequencing data. It was found that 92 RNAs were differentially expressed, including 50 mRNAs, 25 miRNAs and 17 lncRNAs, ceRNA evaluated from 4 aspects number nodes, topological coefficients, closeness centrality betweenness centrality. The...
Associations between exposure to single metals and cognitive impairment or related outcomes have been reported in many previous studies. However, co-exposure more than one metal is common situation. In recent years, studies on the effects of multiple increased, but remain very limited, with a focus populations occupational metals, children, adolescents. The potential relationships mixtures risk adults be clarified.
To investigate the role of ferroptosis in cerebellar injury mice following lead exposure.A total forty SPF C57 were randomly divided into control group, low-dose exposure middle-dose group and high-dose with 10 each group. Mice three groups given 0.25, 0.50, 1.00 g/L acetate through drinking water for twelve weeks respectively. Lead concentration was detected by inductively coupled plasma mass spectrometer. The motor function beam walking test open field test. Pathological changes cerebellum...
Lead (Pb), as a heavy metal, has been applied in Pb battery manufacturing and other industries. Chronic exposure can result inflammatory of central nervous system (CNS) neurobehavior change including learning memory deficits, exploring ability decrease. An understanding the top cellular events its key regulators may provide new insights mechanism neurobehavioral impairment following exposure. In this study, rats were randomly exposed to PbAc at dose 250 mg/L or 500 for 9 weeks. Hippocampus...
Abstract Background Associations between exposure to single metals and cognitive impairment or related outcomes have been reported in many previous studies. However, co-exposure more than one metal is common situation. In recent years, studies on the effects of multiple increased, but remain very limited, with a focus populations occupational metals, children adolescents. The potential relationships mixtures risk adults be clarified. Objectives To investigate associations blood impairment....