A5053861569- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Thermoregulation and physiological responses
- Photoacoustic and Ultrasonic Imaging
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Non-Invasive Vital Sign Monitoring
- Infant Development and Preterm Care
- Neonatal Health and Biochemistry
- Cardiovascular Conditions and Treatments
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Retinopathy of Prematurity Studies
- Prenatal Substance Exposure Effects
- Renal function and acid-base balance
- COVID-19 and healthcare impacts
- Palliative Care and End-of-Life Issues
- Neuroendocrine regulation and behavior
- Heart Rate Variability and Autonomic Control
- Hospital Admissions and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Simulation-Based Education in Healthcare
- Atomic and Subatomic Physics Research
University of Kentucky
2017-2024
Case Western Reserve University
2013-2014
Rainbow Babies & Children's Hospital
2013
Exogenous surfactants to treat respiratory distress syndrome (RDS) are approved for tracheal instillation only; this requires intubation, often followed by positive pressure ventilation promote distribution. Aerosol delivery offers a safer alternative, but clinical studies have had mixed results. We hypothesized that efficient aerosolization of surfactant with low viscosity, early in the course RDS, could reduce need intubation and liquid surfactant.A prospective, multicenter, randomized,...
Continuous and longitudinal monitoring of cerebral blood flow (CBF) in animal models provides information for studying the mechanisms interventions various diseases. Since anesthesia may affect brain hemodynamics, researchers have been seeking wearable devices use conscious animals. We present a diffuse speckle contrast flowmeter (DSCF) probe CBF variations mice. The DSCF consists small low-power near-infrared laser diode as point source an ultra-small CMOS camera 2D detector array, which...
To determine if a home oxygen therapy (HOT) management strategy that includes analysis of recorded oximetry (RHO) data, compared with standard monthly clinic visit assessments, reduces duration HOT without harm in premature infants.The RHO trial was an unmasked randomized clinical conducted 9 US medical centers from November 2013 to December 2017, follow-up February 2019. Preterm infants birth gestation ≤37 + 0/7 weeks, discharged on HOT, and attending their first pulmonary were enrolled....
A recent multinational clinical trial in preterm infants has demonstrated pulmonary and neurodevelopmental benefits from caffeine therapy. Indications for use that study were predominantly treatment of apnea facilitation extubation rather than prophylaxis. There are no studies describe current practice neonatologists regional differences regards to indications starting, monitoring discontinuing methylxanthine therapy premature infants.To characterize the spectrum demonstrate extent which...
Significance: There is an essential need to develop wearable multimodality technologies that can continuously measure both blood flow and oxygenation in deep tissues investigate manage various vascular/cellular diseases. Aim: To a dual-wavelength diffuse speckle contrast oximetry (DSCFO) for simultaneous measurements of variations tissues. Approach: A fiber-free DSCFO probe was fabricated using 3D printing confine two small near-infrared laser diodes tiny CMOS camera positions measurements....
Intermittent hypoxaemia (IH) events are well described in extremely preterm infants, but the occurrence of IH patterns more mature infants remains unclear. The objective this study was to characterise effect gestational age on early postnatal (<28 weeks), very (28–<32 weeks) and moderately (32–<34 infants. As expected, had a significantly higher frequency longer durations greater time with versus In addition, decrease duration comparable This progression should assist clinicians...
BACKGROUND Red blood cell (RBC) transfusion decreases intermittent hypoxemia (IH) events beyond the first week of life. This benefit may be related to improved perfusion respiratory control network. Perfusion index (PI) is a measure provided by pulse oximeter. We hypothesized that in IH after RBC associated with an increase PI. In addition, we assessed value PI and clinical measures predicting effect on IH. STUDY DESIGN AND METHODS prospectively enrolled infants less than 30 weeks' gestation...
Objective A major consequence of prematurity is intermittent hypoxemia (IH). Data from both adult studies and neonatal animal models suggest that IH proinflammatory; however, there limited data in preterm infants. Here, we assess the relationship between systemic inflammation, namely, serum C-reactive protein (CRP) Study Design Serum CRP was measured at 30 days life, time peak frequency. measures (e.g., per cent hypoxemia, frequency, duration) were calculated week prior to collection....
Introduction: Intermittent hypoxemia (IH) is defined as episodic drops in oxygen saturation (SpO2). Preterm infants are at increased risk for IH due to their immature respiratory control/apnea of prematurity. The clinical relevance a relatively new observation with rising evidence linking neonatal morbidities and long term impairment. Hence, assessing factors that influence preterm imperative. Given the epidemic opioid misuse USA, there an urgent need understand impact prenatal exposure on...
The aim of this study was to better understand the relationship between intraventricular hemorrhage and risk development early lung disease in extremely low birth weight infants. We hypothesize that infants with severe have higher respiratory severity scores than mild/no within first 7 days life.
Intermittent hypoxemia (IH), episodic drops in hemoglobin oxygen saturation, is a common problem preterm infants. The extent of IH not apparent clinically because accurately documenting cardiorespiratory events for day-to-day patient care management challenging. Multiple factors place infants at high risk increased IH. These include respiratory immaturity, lung disease, and anemia. Brief episodes desaturation may seem insignificant; however, these have cumulative effect on neonatal outcomes....
Abstract Extremely preterm infants’ hemodynamic instability places them at high risk of brain injury. Currently there is no reliable bedside method to continuously monitor cerebral hemodynamics in the neonatal intensive care unit (NICU). This paper reports a feasibility study adapt and test an innovative speckle contrast diffuse correlation tomography (scDCT) device for noncontact, high-density, 3D imaging blood flow (CBF) infants. The scDCT scans focused point near-infrared illumination...
Abstract Impact The innovative DSCFO technology may serve as a low-cost wearable sensor for continuous bedside monitoring of multiple cerebral hemodynamic parameters in neonatal intensive care units. Concurrent and DCS measurements CBF variations piglet models generated consistent results. No correlation patterns were observed among peripheral preterm neonates, suggesting the importance multi-parameter understanding deep insights regulations during IH events. Integrating correlating...
Intermittent hypoxemia (IH) may influence retinopathy of prematurity (ROP) development in preterm infants, however, previous studies had mixed results. This study aims to assess the and evaluate predictive ability IH measures on Type 1 ROP, a stage beyond which ROP treatment is indicated.
We report a case of contrast-induced hypothyroidism in an extremely preterm infant after percutaneous patent ductus arteriosus (PDA) device closure. Iodine-induced exposure to iodine-containing antiseptics and contrast media has been previously reported infants. However, this is the first undergoing PDA This timely, given closure more frequently utilized. Guidelines for screening thyroid function pre post contrast-requiring procedures may be warranted. Hypothyroidism if left untreated can...