A5100454938- Gout, Hyperuricemia, Uric Acid
- Radiopharmaceutical Chemistry and Applications
- Porphyrin Metabolism and Disorders
- Glaucoma and retinal disorders
- Parathyroid Disorders and Treatments
- Aquaculture disease management and microbiota
- Monoclonal and Polyclonal Antibodies Research
- Atmospheric aerosols and clouds
- Protein purification and stability
- Antibiotics Pharmacokinetics and Efficacy
- RNA Interference and Gene Delivery
- Pancreatic and Hepatic Oncology Research
- Biochemical and Molecular Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Atmospheric chemistry and aerosols
- Hip and Femur Fractures
- Pharmacogenetics and Drug Metabolism
- Breast Cancer Treatment Studies
- Advanced Drug Delivery Systems
- Peptidase Inhibition and Analysis
- Chromosomal and Genetic Variations
- Retinal and Macular Surgery
- Traditional Chinese Medicine Analysis
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
Zhejiang University
2023-2025
Linyi University
2012-2025
Heilongjiang University
2025
Capital Medical University
2014-2025
Ministry of Education of the People's Republic of China
2017-2025
Menlo School
2024-2025
Grail (United States)
2025
Huazhong University of Science and Technology
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2007-2024
Union Hospital
2024
Abstract Inducing cell migration from the edges to center of a wound, promoting angiogenesis, and controlling bacterial infection are very important for diabetic wound healing. Incorporating growth factors antibiotics into hydrogels dressing is considered potential strategy meet these requirements. However, some present drawbacks greatly slow down their development toward application, such as short half‐life high price factors, low antibiotic efficiency against drug‐resistant bacteria,...
The mechanisms of the
It is commonly believed that hybridization might lead to the formation of new polyploidy species, but it unclear whether can produce a homodiploid species. Here, we report spontaneous occurrence crucian carp-like fish (2n = 100) originated from interspecific female common carp (Cyprinus carpio, Cyprininae, 2n × male blunt snout bream (Megalobrama amblycephala, Cultrinae, 48). The phenotype and reproductive traits this were found be very similar those existing diploid species (diploid carp;...
Abstract Pars plana vitrectomy plays an important role in treating serious ophthalmic diseases, which requires subsequent substitution of the natural vitreous. However, current substitutes are known for drawbacks instability, toxicity, and injection‐induced fragmentation, so there is a very urgent need novel artificial vitreous substitute clinical practice. In this study, DNA supramolecular hydrogel evaluated as potential substitute. It observed that exhibits relatively strong mechanical...
// Ling Yu 1,2 , Shiqing Liu 1 Chun Zhang Bo Bruno M. Simões 2 Rachel Eyre Yi Liang 3 Huichao Yan 4 Zheng Wu 5 Weichun Guo Robert B. Clarke Department of Orthopedics, Renmin Hospital Wuhan University, Jiefang Road, Wuhan, Hubei, P.R. China Institute Cancer Sciences, University Manchester, Wilmslow UK State Key Laboratory Oncology in Southern and the Experimental Research, Sun Yat-Sen Center, Dongfeng Guangzhou, Guangdong, Opening for Oversea Scientists, School Basic Medical Science, Donghu...
Transition-metal-catalyzed asymmetric C-P(III) bond formation is a direct method for the construction of P(III)-stereogenic centers; however, achieving high enantioselectivity remains challenge. Herein, an unprecedented Cu-catalyzed dynamic kinetic resolution secondary phosphine-boranes was successfully developed. This C-P(BH3) coupling reaction provided and highly enantioselective synthesis centers, enabling chiral medium-sized benzophosphine-boranes (7-10-membered cycles). A mechanism...
Background: Positron emission tomography (PET) using the tracer 18F-fluorodeoxyglucose (18F-FDG) and [18F] 9-fluoropropyl-(+)-dihydrotetrabenazine (18F-FP-DTBZ) is widely utilized to measure metabolic activity dopaminergic integrity in neurodegenerative diseases such as Parkinson's disease (PD). Previous studies employing 18F-FDG PET have primarily focused on motor or non-motor symptoms, rather than severity of PD. This study aimed glucose metabolism function 18F-FP-DTBZ across various...
Background: Accurate identification of cancer subtypes is essential for effective diagnosis, prognosis, and treatment selection. Traditionally, histologic type, cell origin, underlying pathogenesis are determined using tissue histology, requiring invasive biopsies. This study evaluates the use a ctDNA-based targeted methylation sequencing assay to identify across multiple types through tissue-free blood test. Methods: Within Circulating Cell-free Genome Atlas (CCGA, NCT02889978) study,...
Abstract Introduction: Promoter methylation is a hallmark of cancer and holds promise as biomarker for early detection, prognostication, treatment guidance, response monitoring. This study explores the utility GRAIL’s ctDNA-based targeted assay in detecting gene-specific promoter signals assessing their potential biomarkers. Methods: A comprehensive literature review was conducted to identify genes with proposed biomarker, focusing on those covered by GRAIL's ctDNA assay. We then prioritized...
En-bloc kidney transplantation from low-weight pediatric donors (≤5 kg) is a challenging procedure performed only in limited transplant centers. We retrospectively analyzed the data 42 en-bloc transplants weighing less than 5 kg between September 2014 and 2023. The mean donor body weight was found to be 3.1 ± 1.0 kg, minimum 0.9 kg. At follow-up period of 1,481 days, graft survival rate 76.2% recipient 100.0%. Thrombosis acute rejection were major complications responsible for short-term...
Uricase has proven therapeutic value in treating hyperuricemia but sufficient reduction of its immunogenicity may be the largest obstacle to chronic use. In this study, canine uricase was modified with 5 kDa mPEG-SPA and impact large aggregated uricases cross-linked conjugates induced by difunctional PEG diol on investigated.Recombinant first expressed purified homogeneity. Source 15Q anion-exchange chromatography used separate tetrameric prior pegylation, while DEAE remove Di-acid...
Exploiting cells as vehicles combined with nanoparticles therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem have been used for tumor immunotherapy, tissue regeneration inflammatory disorders, it is known that neutrophils can accumulate brain lesions many diseases including depression. N-Acetyl Pro-Gly-Pro (PGP) peptide shows high specific binding affinity to through CXCR2 receptor. In this study, PGP was modify baicalein-loaded solid lipid...