A5053619899- Traditional Chinese Medicine Analysis
- Parkinson's Disease Mechanisms and Treatments
- Organometallic Complex Synthesis and Catalysis
- Flavonoids in Medical Research
- Nanoparticle-Based Drug Delivery
- Traditional Chinese Medicine Studies
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- RNA Interference and Gene Delivery
- Medicinal Plant Pharmacodynamics Research
- Neurological disorders and treatments
- Healthcare and Venom Research
- Advancements in Transdermal Drug Delivery
- Acupuncture Treatment Research Studies
- Drug Transport and Resistance Mechanisms
- Caveolin-1 and cellular processes
- Immune cells in cancer
- Asymmetric Hydrogenation and Catalysis
- Phagocytosis and Immune Regulation
- Ferrocene Chemistry and Applications
- Metabolomics and Mass Spectrometry Studies
- Osteoarthritis Treatment and Mechanisms
- Ginseng Biological Effects and Applications
- Analytical Chemistry and Chromatography
- Neurological Disease Mechanisms and Treatments
Heilongjiang University of Chinese Medicine
2012-2024
Henan University of Science and Technology
2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
First Affiliated Hospital of Wenzhou Medical University
2015-2023
Wenzhou Medical University
2015-2023
Heilongjiang University
2008-2022
China Pharmaceutical University
2014-2017
Huazhong University of Science and Technology
2017
Jiangsu University
2015
Chengdu Military General Hospital
2014
Cerebral ischemia (CI) results from inadequate blood flow to the brain. The difficulty of delivering therapeutic molecules lesions resulting CI hinders effective treatment this disease. inflammatory response following offers a unique opportunity for drug delivery ischemic brain and targeted cells because recruitment leukocytes stroke core penumbra. In present study, neutrophils monocytes were explored as cell carriers after selectively carrying cRGD liposomes, which effectively transmigrated...
About 40% of the marketed drugs and 70-90% new drug candidates are insoluble in water therefore poorly bioavailable, which significantly compromises their therapeutic effects. A formulation nanosuspensions achieved by reducing pure particle size down to seb-micron range is one most promising approaches overcome insolubility. However, nanosuspension formulations subject instability because nucleation growth. Therefore, a stabilizer needed be incorporated into during preparation process...
In China, a decoction is one of the most common clinical dosage forms. Nanometre aggregates (NAs), which often consist circular or irregular nanoparticles, have been observed in previous research on decoctions. A Bai-Hu-Tang (BHT) an ancient form China. The purpose this work was to isolate and characterize NAs from BHT investigate their antipyretic effect. prepared by traditional method. mechanism active components were investigated high-speed centrifugation, transmission electron microscopy...
Exploiting cells as vehicles combined with nanoparticles therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem have been used for tumor immunotherapy, tissue regeneration inflammatory disorders, it is known that neutrophils can accumulate brain lesions many diseases including depression. N-Acetyl Pro-Gly-Pro (PGP) peptide shows high specific binding affinity to through CXCR2 receptor. In this study, PGP was modify baicalein-loaded solid lipid...
It is disclosed how the sizes of rod‐shaped paclitaxel‐nanosuspensions (PTX‐Ns) that are less than 500 nm affect their in vitro and vivo performances. A size reduction from to 160 enhances cellular uptake subsequent cytotoxicity, due participation caveolae‐mediated endocytosis; moreover, ability PTX‐Ns penetrate tumors well correlated with extent which caveolae pathway participates uptake, as target markedly promoted decreased nm. Also, alters performance tumor targeting. via enhanced...
A novel polyethylene glycol-polycaprolactone-poly-l-tyrosine (MPEG-PCL-PTyr) amphiphilic triblock copolymer micelle was synthesized for the first time. 10-hydroxycamptothecin (HCPT) embedded in MPEG-PCL-PTyr nanomicelles using emulsion solvent evaporation method. series of conducted to confirm structure compound and evaluate physical properties nanomicelles. Cellular uptake, cytotoxicity, apoptosis were assessed flow cytometry MTT assays. Confocal microscopy results demonstrated that...
Abstract: Immunocytes, mainly neutrophils and monocytes, exhibit an intrinsic homing property, enabling them to migrate sites of injury inflammation. They can thus act as Trojan horses carrying concealed drug cargoes while migrating across impermeable barriers disease, especially the blood–brain barrier (BBB). In this study, target circulating phagocytic cells, we formulated negatively charged nanosize liposomes loaded trefoil factor 3 (TFF3) into by pH-gradient method. According optimized...
Phylogenetic tree construction process might produce many candidate trees as the "best estimates." As number of constructed phylogenetic grows, need to efficiently compare their topological or physical structures arises. One comparison's software tools, Mesquite's Tree Set Viz module, allows rapid and efficient visualization comparison distances using multidimensional scaling (MDS). Tree-distance measures, such Robinson-Foulds (RF), for distance among different have been implemented in Viz....
a 黑龙江中医药大学药学院 哈尔滨 150040) ( b 华中科技大学同济医学院药学院 武汉 430030) c 佳木斯大学药学院 佳木斯 1504007) 摘要 利用柱层析和高效液相色谱等分离技术从毛果南烛 Lyonia ovalifolia var.hebecarpa 的叶中分离得到了 3 个三萜 皂苷类化合物, 借助 HRESIMS 和 NMR 等波谱手段以及化学方法鉴定其结构分别 3β-O-ɑ-L-阿拉伯吡喃糖氧基-齐墩 果-12-烯-23,25-二醇(1)、 3β-O-α-L-阿拉伯吡喃糖氧基-齐墩果-12-烯-1β,23-二醇(2)和 25-羟基-3β-O-β-D-葡萄糖吡喃糖氧 基-24α-O-α-L-阿拉伯吡喃糖氧基-9,10-开环-羊毛脂烷-10-烯-30-酸(3).化合物 1 及其苷元是新化合物, 已知化合物 2 均为首次从该植物中分离得到.首次对化合物 及其苷元进行了 数据归属.同时, 筛选了所得 个三萜皂苷化 合物 1～3 的体外抗肿瘤活性, 结果显示化合物 对五种肿瘤细胞 HL-60、MCF
Shuang Huang Lian Injection (SHLI) has been used in China for over 30 years as an effective and widely Chinese herbal prescription to treat acute respiratory infectious. SHLI has, however, caused many severe anaphylactoid reactions. It is important identify the potential components of SHLI. Spectrum-effect relationships were explore potentially components. Based on original formula, honeysuckle, Fructus Forsythiae Radix Scutellariae extracts prepared combined appropriate proportions. The...
This study was performed to investigate the influence of traditional Chinese medicines in Zhenju antihypertensive compound (ZJAHC) on oral absorption hydrochlorothiazide (HCT) both vitro and vivo.Caco-2 cells situ closed loop system were used possible mechanism Chinese-Western medicine interaction transepithelial transport uptake HCT. The TCMs pharmacokinetics bioavailability HCT also studied reveal vivo.In an intestinal perfusion study, cumulative amount ZJAHC group (506.05 μg ± 96.03)...