A5042524524- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Medicinal Plant Pharmacodynamics Research
- Neurological Disease Mechanisms and Treatments
- Ginseng Biological Effects and Applications
- Mangiferin and Mango Extracts
- Acupuncture Treatment Research Studies
- Polysaccharides and Plant Cell Walls
- Toxin Mechanisms and Immunotoxins
- Traditional Chinese Medicine Studies
- Berberine and alkaloids research
- Ginger and Zingiberaceae research
Heilongjiang University of Chinese Medicine
2015-2024
Heilongjiang University
2009
In China, a decoction is one of the most common clinical dosage forms. Nanometre aggregates (NAs), which often consist circular or irregular nanoparticles, have been observed in previous research on decoctions. A Bai-Hu-Tang (BHT) an ancient form China. The purpose this work was to isolate and characterize NAs from BHT investigate their antipyretic effect. prepared by traditional method. mechanism active components were investigated high-speed centrifugation, transmission electron microscopy...
The decoction turns into a complex multiphase system following exposure to high temperature and chemical environment. However, the differences in concentration of key active ingredients different phase states release drugs sedimentary have yet be elucidated. A simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed validated for simultaneous quantitative determination brucine, strychnine, liquiritin, isoliquiritin, isoliquiritigenin...
Glycyrrhiza glabra L. (GG) and Strychnos nux-vomica (NV) are traditional Chinese medicines (TCMs). Changes in the chemical composition may occur before after GG-NV compatibility. Ultra-performance liquid chromatography Q-exactive Orbitrap mass spectrometry (UPLC-QE-Orbitrap-MS) was applied here to study difference components of GG NV decoctions they were combined. The changes combination determined.
To evaluate the detoxification effect of a combination Radix Glycyrrhizae (GU) and Semen Strychni (SN) from toxicokinetics drug tissue distribution perspectives, decoctions processed SN codecoction GU (SGN) were prepared, an HPLC-ESI-MS/MS method was developed to monitor severe exposure level in 1-month experiments detect brucine strychnine rats. The toxicokinetic characteristics before after addition analyzed. successfully applied GU. results show that decreased blood concentration toxic...
The present study established the spectrum-effect relationship model of flavonoids in Citri Reticulatae Pericarpium(CRP) from 15 batches Liujunzi Decoction and statistically analyzed correlation between chemical peaks efficacy to identify main effective components. HPLC fingerprints CRP were established. analysis was carried out on Venusil XBP C_(18)(L) column(4.6 mm×250 mm, 5 μm) at 30 ℃ with acetonitrile-water(containing 0.1% formic acid) as mobile phase for gradient elution, a flow rate...