A5103274013- Bioinformatics and Genomic Networks
- Radiomics and Machine Learning in Medical Imaging
- Biomedical Text Mining and Ontologies
- Intensive Care Unit Cognitive Disorders
- Cancer Cells and Metastasis
- Anesthesia and Neurotoxicity Research
- Qualitative Comparative Analysis Research
- COVID-19 diagnosis using AI
- Management and Organizational Studies
- Accounting and Organizational Management
- Anesthesia and Sedative Agents
- Lung Cancer Diagnosis and Treatment
- Big Data and Business Intelligence
- AI in cancer detection
- Computational Drug Discovery Methods
- Business Strategy and Innovation
- Innovation and Knowledge Management
- ERP Systems Implementation and Impact
- Foot and Ankle Surgery
- Orthopedic Infections and Treatments
- Information Technology Governance and Strategy
- Sentiment Analysis and Opinion Mining
- Real-Time Systems Scheduling
- Streptococcal Infections and Treatments
- Preterm Birth and Chorioamnionitis
Southern Taiwan University of Science and Technology
2023-2025
Rockefeller University
2023
HCA Healthcare
2022
Kun Shan University
2010-2020
University of Nevada, Reno
2015-2020
Mills College
2018
University of Iowa
2017
Washington and Lee University
2015-2016
Boise State University
2015-2016
University of California, San Francisco
2009-2010
ANESTHESIA kills neonatal brain cells of several animal species, including primates.1A combination γ-aminobutyric-acid (GABA)–ergic and N -methyl-d-aspartate antagonist agents is particularly neurotoxic; however propofol, isoflurane, ketamine, midazolam have all caused apoptosis individually.1We shown that 4 h hypercapnia, which a similar degree distribution cell death as did not cause neurocognitive deficit.2Likewise, 2 isoflurane in many areas the relevant to behavioral outcome tested, but...
We performed the first genome-wide expression analysis directly comparing profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic (LSC) from patients with acute myeloid leukemia (AML). Comparing signature HSC to that LSC, we identified 3,005 differentially expressed genes. Using 2 independent analyses, multiple pathways are aberrantly regulated in compared HSC. Several pathways, including Wnt signaling, MAP Kinase Adherens Junction, well known for their role...
Histopathologic assessment is indispensable for diagnosing colorectal cancer (CRC). However, manual evaluation of the diseased tissues under microscope cannot reliably inform patient prognosis or genomic variations crucial treatment selections. To address these challenges, we develop Multi-omics Multi-cohort Assessment (MOMA) platform, an explainable machine learning approach, to systematically identify and interpret relationship between patients' histologic patterns, multi-omics, clinical...
MILLIONS of neonates undergo anesthesia for surgical or diagnostic procedures each year.1,2Anesthesia kills neonatal brain cells several animal species, including primates,3–6and causes long-term neurocognitive dysfunction.3,5,6Consequently, anesthesia-induced apoptotic cell death is a growing concern within the community, public, and regulatory authorities alike.7However, causal link between dysfunction lacking. If such relationship existed, degree should predict severity dysfunction. We...
Although traditional chemotherapy kills a fraction of tumor cells, it also activates the stroma and can promote growth survival residual cancer cells to foster recurrence metastasis. Accordingly, overcoming host response induced by could substantially improve therapeutic outcome patient survival. In this study, resistance treatment metastasis has been attributed expansion stem-like tumor-initiating (TICs). Molecular analysis in neoadjuvant chemotherapy–treated human desmoplastic cancers...
Empirical evidence demonstrates that motivated employees mean better organizational performance. The objective of this conceptual paper is to articulate the progress has been made in understanding employee motivation and performance, suggest how theory concerning performance may be advanced. We acknowledge existing limitations development an alternative research approach. Current based on conventional quantitative analysis (e.g., multiple regression analysis, structural equation modeling)....
Background Chest computed tomography (CT) is crucial for the detection of lung cancer, and many automated CT evaluation methods have been proposed. Due to divergent software dependencies reported approaches, developed are rarely compared or reproduced. Objective The goal research was generate reproducible machine learning modules cancer compare approaches performances award-winning algorithms in Kaggle Data Science Bowl. Methods We obtained source codes all solutions Bowl Challenge, where...
Anesthetic drugs cause brain cell death and long-term neurocognitive dysfunction in neonatal rats. Recently, human data also suggest that anesthesia early life may cognitive impairment. The connection between decline is uncertain. It conceivable mechanisms other than contribute to outcome of anesthesia. In a series experiments, we demonstrate isoflurane exposure causes significant hypercarbia postnatal day 7 rats or carbon dioxide for 4 h provoked death. However, 1 was not sufficient...
Roughly, 10% of elderly patients develop postoperative cognitive dysfunction. General anesthesia impairs spatial memory in aged rats, but the mechanism is not known. Hippocampal neurogenesis affects learning and isoflurane neonatal young adult rats. We tested hypothesis that hippocampal function rats.Isoflurane was administered to 16-month-old rats at one minimum alveolar concentration for 4 h. FluoroJade staining performed assess brain cell death 16 h after administration. Dentate gyrus...
ABSTRACT Accounting researchers are becoming increasingly interested in the performance effects of business intelligence (BI) systems their role as management control systems. Extant research focuses on adopting and implementing such However, there is less known about how organizations use information BI for once implemented, whether this translates into organizational performance. We utilize theoretical connection between learning to explain system through learning. Evidence from recent...
1603 Background: Previous studies have established artificial intelligence (AI) algorithms to classify cancer types, providing real-time diagnostic support. In addition, AI models identified previously unknown pathology patterns associated with genomic profiles. However, these exhibit variable performance in different demographic groups, and the causes remain largely unknown. To address this challenge, we investigated relationships between biases mutation rate disparities across populations...
e23230 Background: Pathology foundation models, a type of state-of-the-art deep learning models trained on diverse and large-scale datasets, have shown the ability to extract useful pathology patterns for cancer diagnosis. However, their reliability across different demographic groups is hindered by limited training samples from minority populations. To address this challenge, we developed generative AI-based approach, Fairness Denoising Diffusion Probabilistic Models (DDPM), enhance...
There are more than 3.7 million published articles on the biological functions or disease implications of proteins, constituting an important resource proteomics knowledge. However, it is difficult to summarize millions findings in literature manually and quantify their relevance biology diseases interest. We developed a fully automated bioinformatics framework identify prioritize proteins associated with any entity. used 22 targeted areas Biology/Disease-driven (B/D)-Human Proteome Project...
Histopathological classification of human prostate cancer (PCA) relies on the morphological assessment tissue specimens but has limited prognostic value. To address this deficiency, we performed comparative transcriptome analysis prostatic acini generated in a three-dimensional basement membrane that recapitulates differentiated characteristics and gene expression profile glandular epithelial tissue. We then applied an acinar morphogenesis–specific to two independent cohorts patients with...
The Society for Obstetric Anesthesia and Perinatology (SOAP) annual meeting provides a forum to present new scientific work with the goal of broader dissemination knowledge. objective this study was evaluate proportion research abstracts presented at SOAP meetings, from 2010 2014, which resulted in peer-reviewed publications. abstract-to-publication rate compared percent biomedical meetings resulting publication, as estimated by 2007 Cochrane Review. lower than that Review (26.8% vs 44.5%, P...
Proteomics technologies and bioinformatics tools have been widely used to analyze protein-protein interactions of complex biological systems, which are essential for understanding the mechanisms human cancer biology. Although many studies tackled problem high-throughput interaction identifications in <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Saccharomyces</i> xmlns:xlink="http://www.w3.org/1999/xlink">cerevisiae</i> ,...
TREK-1, an outward-rectifying potassium channel activated by stretch, is found in the myometrium of pregnant women. Decreased expression TREK-1 near term suggests that may contribute to uterine quiescence during gestation. Five alternatively spliced variants were identified mothers who delivered spontaneously preterm (<37 wk), leading hypothesis these could interfere with function or expression. To investigate a potential role for variants, immunofluorescence, cell surface assays, Western...
Targeted metabolomics and biochemical studies complement the ongoing investigations led by Human Proteome Organization (HUPO) Biology/Disease-Driven Project (B/D-HPP). However, it is challenging to identify prioritize metabolite chemical targets. Literature-mining-based approaches have been proposed for target proteomics studies, but text mining methods prioritization are hindered a large number of synonyms nonstandardized names each entity. In this study, we developed cloud-based literature...