A5062256745- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurology and Historical Studies
- Botulinum Toxin and Related Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Genetic Neurodegenerative Diseases
- History of Medicine Studies
- Autism Spectrum Disorder Research
- Mental Health and Psychiatry
- Cerebral Palsy and Movement Disorders
- Neurological and metabolic disorders
- Neurological diseases and metabolism
- Metabolism and Genetic Disorders
- Glycogen Storage Diseases and Myoclonus
- Neuroscience and Neuropharmacology Research
- Protein Degradation and Inhibitors
- Attention Deficit Hyperactivity Disorder
- Historical and Scientific Studies
- History of Medical Practice
- Schizophrenia research and treatment
- Multiple Myeloma Research and Treatments
- Eating Disorders and Behaviors
- Epilepsy research and treatment
- Balance, Gait, and Falls Prevention
- Mitochondrial Function and Pathology
Medical College of Wisconsin
2004-2025
Rush University
1985-2025
Rush University Medical Center
2012-2024
University of Illinois Chicago
2017
Presbyterian St. Luke's Medical Center
1992-2015
Centre for Movement Disorders
2007-2008
Lutheran Hospital
2004
St. Luke's Hospital
2003-2004
Froedtert Hospital
2004
University of California, Los Angeles
2003
As part of a safety and tolerability study, 65-year-old man with Parkinson's disease (PD) received monthly intracerebroventricular injections glial-derived neurotrophic factor (GDNF). His parkinsonism continued to worsen following GDNF treatment. Side effects included nausea, loss appetite, tingling, L'hermitte's sign, intermittent hallucinations, depression, inappropriate sexual conduct. There was no evidence significant regeneration nigrostriatal neurons or intraparenchymal diffusion the...
Abstract We studied the prevalence and character of pain in Parkinson's disease (PD) its association with motor fluctuations. Of 95 outpatients, 46% experienced they attributed to PD. Patients were younger but no more disabled on objective scores than patients without pain. Musculoskeletal, dystonic, join pains most frequent. Painful episodes, especially musculoskeletal cramps, usually occurred when parkinsonian disability was maximal.
Whether Parkinson disease (PD) and dementia with Lewy bodies (DLB) represent 2 distinct nosologic entities or are diverse phenotypes of body is subject to debate.To determine the accuracy diagnoses disease, PD, DLB by validating clinical 6 neurologists neuropathologic findings identify early predictors diagnoses.Six raters who were unaware analyzed 105 vignettes corresponding 29 cases (post hoc analysis 15 patients PD 14 DLB) 76 without whose confirmed through autopsy findings.Sensitivity...
In 19 patients with severe Parkinson's disease, we replicated the surgical procedures developed by Madrazo et al. for transplantation of adrenal medulla to striatum, and followed them six months after operation. We monitored their motor function use standardized scales determined amount quality "on" "off" time (the hours waking day when anti-parkinsonism medications were effective ineffective, respectively). found significant improvement in focal areas function. The mean percentage on during...
Objective: To define the long-term outcome in Gilles de la Tourette syndrome (GTS) using objective rating measures.
<b><i>Objectives:</i></b> To examine the long-term outcome of PD patients with psychosis requiring antipsychotic therapy; to explore predictors mortality, nursing home placement, dementia, and persistent psychosis; compare outcomes those vs whose resolved. <b><i>Methods:</i></b> Baseline data available from 59 enrolled in PSYCLOPS (PSychosis CLOzapine Study) trial included age, age at onset PD, duration psychosis, character medications, living setting, scores for Mini-Mental State...
The presentation of symptoms for multiple system atrophy (MSA) varies. Because there are no specific markers its clinical diagnosis, the diagnosis rests on results neuropathologic examination. Despite several clinicopathologic studies, diagnostic accuracy MSA is unknown.To determine and to identify, as early possible, those features that would best predict MSA.One hundred five autopsy-confirmed cases related disorders (MSA [n=16], non-MSA [n=89]) were presented vignettes 6 neurologists...
Previously, we published a video-based objective rating scale of tics that met reliability and validity criteria for measurement five domains tic disability. In the original form, scale's metric properties did not permit internal comparison each impairment provide total score use as primary outcome measure. this study, retained videotape protocol but tested whether modified scoring system corrected these limitations. The new method rated assigned data to ratings 0–4 on disability categories:...
Tardive dyskinesia is an extrapyramidal syndrome associated with the chronic administration of major neuroleptic agents. The pathogenesis disorder appears to relate striatal dopaminergic receptor site blockade; pathophysiology tardive resultant denervation hypersensitivity. Agents that deplete brain dopamine are mainstay therapy for dyskinesia. Cholinergic agents potentially modulate balance between and acetycholine in striatum offer possible additional therapeutic options. Clearly,...
The Unified Parkinson's Disease Rating Scale (UPDRS) is widely used to assess disease (PD) disability but its metric properties have not been extensively studied. We investigated the factor structure and internal consistency of Motor Examination section UPDRS in a sample 294 consecutive patients with idiopathic PD who were assessed while "on" state. There was high degree consistency. Factor analysis revealed six clinically distinct factors, three bradykinesia measures (axial/gait, right...
<h3>Background</h3> To date, to our knowledge, there is no systematic presentation of treatment outcome in large series patients clinically diagnosed as having corticobasal degeneration. <h3>Objective</h3> evaluate the clinical and <h3>Subjects</h3> We gathered case seen 8 major movement disorder clinics during last 5 years who were ganglionic <h3>Methods</h3> Using a chart review method, we recorded presentation, medications used, response medications, adverse effects. <h3>Results</h3> A...
Thirteen centers participated in a multicenter database with systematic evaluation of US and Canadian patients who had adrenal medullary transplantation for Parkinson9s disease. This voluntary registry collected demographic, safety, efficacy data using the same scoring measures over 2-year follow-up period. Baseline on 61 56 were compared. Eighteen percent died during study period, one-half these deaths related or questionably to surgery. Of remaining 45 data, global improvement, defined as...
Sirtuins are NAD+-dependent protein deacylases and key metabolic regulators, coupling the cellular energy state with selective lysine deacylation to regulate many downstream processes. Humans encode seven sirtuin isoforms (Sirt1-7) diverse subcellular localization deacylase targets. considered protective anti-aging proteins since increased activity is canonically associated lifespan extension decreased developing aging-related diseases. However, sirtuins can also assume detrimental roles...
Abstract The Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) assesses the character and severity of cervical dystonia (CD). We developed a teaching tape TWSTRS scoring for motor symptoms CD. provides investigators with visual representations each component section as agreed upon by three independently raters. rate agreement nondichotomous components was always significant, Kendall's coefficient concordance W ranging between 0.98 0.76 (p < 0.01 all measures). For two...
Abstract We developed a teaching tape of the motor section Unified Parkinson's Disease Rating Scale (UPDRS) to provide investigators with visual document three raters' interpretations scoring system for each item except rigidity. The rate agreement selected samples was always significant, Kendall's coefficient concordance W ranging between 0.97 and 0.62. also provided full UPDRS ratings on sample patients that may be used training multicenter studies assure uniformity rating. study...
To study the frequency and severity of acute orthostatic hypotension (OH) in patients with Parkinson's disease who are starting dopamine agonist therapy.In context an outpatient clinical practice, 29 consecutive were therapy brought into clinic for their first dose agonist. After a baseline supine standing blood pressure assessment, given test either pergolide mesylate (0.025, 0.05, 0. 125, or 0.25 mg), pramipexole dihydrochloride (0.125 ropinirole hydrochloride mg). At 3 selected times,...
Twelve parkinsonian patients on long-term levodopa therapy developed intermittent, myoclonic body jerks. The movements consisted of single unilateral or bilateral abrupt jerks the extremities and occurred most frequently during sleep. Although directly related to daily dosage levodopa, myoclonus was specifically blocked by serotonin antagonist, methysergide. Levodopa-induced may be intermittent increases activity in brain results from levodopa-induced dysregulation activity.