A5082797985- Infectious Encephalopathies and Encephalitis
- Long-Term Effects of COVID-19
- Multiple Sclerosis Research Studies
- Prion Diseases and Protein Misfolding
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Antifungal resistance and susceptibility
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- Dementia and Cognitive Impairment Research
- Syphilis Diagnosis and Treatment
- Polyomavirus and related diseases
- HIV Research and Treatment
- Bacterial Infections and Vaccines
- Cerebrospinal fluid and hydrocephalus
- Neurological and metabolic disorders
- T-cell and Retrovirus Studies
- Mosquito-borne diseases and control
- Parvovirus B19 Infection Studies
- Intensive Care Unit Cognitive Disorders
- Infectious Diseases and Tuberculosis
- Genetic Neurodegenerative Diseases
- Systemic Sclerosis and Related Diseases
- Peripheral Neuropathies and Disorders
- Neurological diseases and metabolism
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2013-2024
Universidade de São Paulo
1998-2024
Instituto de Medicina Tropical
2021
Fundação Padre Albino
2018
Hospital Sírio-Libanês
2015
Hospital Universitário da Universidade de São Paulo
1990-2009
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2007
Fleury S.A. (Brazil)
2007
Universidade Federal de São Paulo
2007
ABSTRACT Background: More than one-third of COVID-19 patients present neurological symptoms ranging from anosmia to stroke and encephalopathy. Furthermore, pre-existing conditions may require special treatment be associated with worse outcomes. Notwithstanding, the role neurologists in is probably underrecognized. Objective: The aim this study was report reasons for requesting consultations by internists intensivists a COVID-19-dedicated hospital. Methods: This retrospective carried out at...
Abstract Introduction Mild cognitive impairment (MCI) is classically considered a transitional stage between normal aging and dementia. Non-amnestic MCI (naMCI) patients, however, typically demonstrate deficits other than memory decline. Furthermore, as group, naMCI have lower rate of an eventual dementia diagnosis compared to amnestic subtypes (aMCI). Unfortunately, studies investigating biomarker profiles are scarce. The study objective was investigate the regional brain glucose metabolism...
To describe the clinical, neurological, neuroimaging, and cerebrospinal fluid (CSF) findings associated with encephalopathy in patients admitted to a COVID-19 tertiary reference center. We retrospectively reviewed records of consecutive evaluated by consulting neurology team from March 30, 2020 through May 15, 2020. Fifty-five confirmed SARS-CoV-2 were included, 43 whom showed encephalopathy, further divided into mild, moderate, severe groups. Nineteen (44%) had undergone mechanical...
In recent years, the diagnostic accuracy of Alzheimer's disease has been enhanced by development different types biomarkers that indicate presence neuropathological processes. addition to improving patient selection for clinical trials, can assess effects new treatments on pathological However, there is concern about indiscriminate and poorly supported use biomarkers, especially in asymptomatic individuals or those with subjective cognitive decline. Difficulties interpreting these tests,...
Cryptococcal meningitis is the most common cause of opportunistic in HIV-infected patients Brazil and causes unacceptable high mortality rates. In this study, with a first episode culture-proven cryptococcal cerebrospinal fluid (CSF) were prospectively included order to evaluate sensitivity antigen (CrAg) lateral flow assay (LFA) serum, CSF, whole blood (fingerstick), fresh urine. addition, other neurological confirmed diseases specificity CrAg LFA serum. Twenty 19 them, positive (95%...
HTLV-1 antibodies were investigated in serum and CSF of 150 patients with neurologic disorders mainly myelopathies. The considered into three groups according to the possible relationship their disease presence antibodies: no risk (control group), occasional group, group. In this latter are 56 crural spastic paraparesis or paraplegia unknown etiology (SP). tested by passive particle-agglutination method for anti-ATLA antibody detection. search was negative all control positive (serum and/or...
The frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) varies widely in different populations. objective this study was determine these OCB a group MS city São Paulo. Techniques used detect consisted isoelectric focusing followed by immunoblotting. Oligoclonal were found 49 (54.4%) out 90 clinically definite MS; (31.2%) 16 isolated syndrome; 7 (17.9%) 39 inflammatory disorders central nervous system (IDCNS), and none...
Genetic susceptibility is a well-recognized factor in the onset of multiple sclerosis (MS). The objective this study was to determine frequency oligoclonal bands (OCB) restricted cerebrospinal fluid, an ethnically mixed group MS patients city São Paulo, Brazil. Techniques used detect OCB consisted isoelectric focusing followed by immunoblotting. were found 49 (54.4%) out 90 with clinically definite MS; 23 brown/black patients, 17 (73.9%) OCB+; 66 white 32 (48.5%) and only patient yellow OCB+...
Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central peripherical nervous systems. A considerable amount of publications have been made recent years, although cannabis has known for over a thousand years. Scientific Departments from Brazilian Academy Neurology described evidence medical use their areas. Literature is constantly changing, possible new can emerge next days or months. Prescription these substances must be...
Cerebrospinal fluid (CSF) analysis is an important diagnostic tool for many conditions affecting the central nervous system (CNS), especially CNS infectious diseases. Despite its low specificity, CSF white blood cell counts, protein levels, serum glucose ratio and lactate measurement are useful in differentiating infections caused by distinct groups of pathogens. direct examination cultures can identify causative organisms antibiotic sensitivities as well. Adjunctive tests such latex...
Abstract Background The radiological manifestations of central nervous system (CNS) cryptococcosis are diverse and often subtle. There is heterogeneity on how different neuroimaging patterns impact prognosis. This study aims to assess the association between clinical outcomes CNS cryptococcosis. Methods All patients with July 2017 April 2023 who underwent brain magnetic resonance imaging (MRI) were included. primary outcome was mortality during hospitalisation. Secondary readmission,...
The objective of this study was to characterize the prevalence viral encephalitis due arbovirus infection Togaviridae and Flaviviridae families in São Paulo, Brazil. A total 500 cerebrospinal fluid (CSF) samples collected between August 2012 January 2013, from patients with symptoms acute were analyzed. Findings suggestive encephalitis—elevations cell concentration, glucose protein—were observed 234 (46.8%) samples, designated as Group 1. remaining 266 comprised 2. All tested for...
The recent development of IQ-CSF, the second generation real-time quaking-induced conversion (RT-QuIC) using cerebrospinal fluid (CSF), for diagnosis Creutzfeldt-Jakob Disease (CJD) represents a major diagnostic advance in field. Highly accurate results have been reported with encouraging reproducibility among different centers. However, availability is still insufficient, and only few research centers access to method developing countries. In Brazil, we had 603 suspected cases CJD since...