A5100781942- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Cardiac, Anesthesia and Surgical Outcomes
- Peroxisome Proliferator-Activated Receptors
- Enterobacteriaceae and Cronobacter Research
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Medical Imaging Techniques and Applications
- ATP Synthase and ATPases Research
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Alzheimer's disease research and treatments
- Microtubule and mitosis dynamics
- Advanced Photocatalysis Techniques
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- Heme Oxygenase-1 and Carbon Monoxide
- Ginseng Biological Effects and Applications
- Gas Sensing Nanomaterials and Sensors
- Traumatic Brain Injury and Neurovascular Disturbances
- Sirtuins and Resveratrol in Medicine
Shenzhen Second People's Hospital
2016-2025
Shanxi University
2023-2025
Beijing University of Chinese Medicine
2023-2025
Chengdu Medical College
2025
China-Japan Friendship Hospital
2025
Hebei Medical University
2025
Shenzhen University Health Science Center
2018-2024
Tianjin Medical University Cancer Institute and Hospital
2024
Changchun University of Chinese Medicine
2023-2024
Chongqing Technology and Business University
2024
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with an extremely low survival rate. New and effective approaches for treatment are therefore urgently needed. Here, we successfully developed M1-like macrophage-derived extracellular vesicles (M1EVs) that overcome multiple challenges via guidance from two macrophage-related observations in clinical specimens GBM patients: enrichment of M2 macrophages GBM; origination majority infiltrating macrophage peripheral blood. To...
The root of Bupleurum yinchowense Shan et Y. Li, a well-known medicinal plant in China, was originally documented the "Shennong's Herbal", which is oldest Chinese materia medica monographs. It has action soothing liver and relieving constraint for improving symptoms emotional instability such as depression, anxiety phobia. vivo experiment our previous study showed an efficacy Total Saikosaponins (TSS) from acute stress chronic unpredictable mild models. Nevertheless, there are no studies on...
Background/Aims: Cajaninstilbene acid (3-hydroxy-4-prenyl-5-methoxystilben-2 -carboxylic acid, CSA), a natural stilbene isolated from the leaves of Cajanus cajan, has attracted considerable attention for its wide range pharmacological activities. This study investigated whether CSA protects against corticosterone (CORT)-induced injury in PC12 cells and examined potential mechanisms underlying this protective effect. Methods: Cell viability cytotoxicity were detected using...
Abstract Intracerebral hemorrhage is the most dangerous complication in tPA thrombolytic therapy for ischemic stroke, which occurs as a consequence of endothelial cell death at blood–brain barrier (BBB) during reperfusion. We have previously shown that cerebral ischemia‐induced rapid occludin degradation and BBB disruption. Here we demonstrated an important role facilitating evolution cells toward death. Cultured brain microvascular (bEnd.3 cells) were exposed to oxygen‐glucose deprivation...
Dystonia is a neurological movement disorder that clinically and genetically heterogeneous. Herein, we report the identification novel homozygous missense mutation, c.156 C > A in VPS16, co-segregating with disease status Chinese consanguineous family adolescent-onset primary dystonia by whole exome sequencing homozygosity mapping. To assess biological role of mutation generated mice targeted site Vps16 through CRISPR-Cas9 genome-editing approach. mutant exhibited significantly impaired...
Gliomas are the most common type of primary brain tumour in central nervous system adults. The long non-coding RNA (lncRNA) HOXA transcript at distal tip (HOTTIP) is transcribed from 5' locus. HOTTIP has recently been shown to be dysregulated and play an important role progression several cancers. However, little known about whether how regulates glioma development. In this study, we assayed expression tissue samples cell lines using real-time polymerase chain reaction defined biological...
Abstract Alternatively activated (M2) macrophage promotes glioma progression and immune escape as the most immunocyte in microenvironment. Finding out key protein regulating M2 polarization is necessary for improving treatment. Whether immunity related GTPase M (IRGM) involved development unknown. IRGM marker CD206 expression were examined using immunohistochemistry among 35 11 non‐cancerous brain specimens. We found scores positively correlated with specimens monocyte proportion blood...
Pituitary adenoma (PA) includes invasive pituitary (IPA) and noninvasive (NIPA), which are associated with the endocrine system. The gut microbiome plays an important role in human metabolism, but association between remains unclear. A total of 44 subjects were enrolled this study. Of these, 29 PA patients further divided into IPA ( n = 13) NIPA 16), while 15 healthy age-matched defined as control subjects. We collected faecal samples characterized microbial profiles by metagenomic...
Introduction: Due to its highly aggressiveness and malignancy, glioblastoma (GBM) urgently requires a safe effective treatment strategy. Zeylenone, natural polyoxygenated cyclohexenes compound isolated from Uvaria grandiflora , has exhibited potential biological activities in various human diseases, including tumors. Methods: We designed synthesized series of (+)-Zeylenone analogues evaluated their anti-GBM roles through structural-activity analysis. Cell Counting Kit-8, TUNEL, transwell...
Background Numerous deep leaning methods for low-dose computed technology (CT) image denoising have been proposed, achieving impressive results. However, issues such as loss of structure and edge information low efficiency still exist. Objective To improve quality, an enhanced multi-dimensional hybrid attention LDCT network based on detection is proposed in this paper. Methods In our network, we employ a trainable Sobel convolution to design enhancement module fuse triplet (ETAN) after each...
Abstract The approval of JAK inhibitors, represented by baricitinib, for the treatment alopecia areata (AA) has ushered in a new era. However, their excessive immunosuppressive effects have also raised numerous concerns. Therefore, development inhibitors with different selectivities may enhance drug safety while maintaining therapeutic efficacy. CS12192, developed our team, is selective JAK3 inhibitor that partially inhibits JAK1 and TBK1. In this study, we evaluate effectiveness CS12192...