A5062101586- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Coffee research and impacts
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Polyamine Metabolism and Applications
Université Toulouse III - Paul Sabatier
2020-2023
Centre National de la Recherche Scientifique
2015-2023
Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération
2023
Centre de Biologie du Développement
2020
Institut de Biologie Valrose
2019
Inserm
2019
Sorbonne Université
2015-2016
Institut de Biologie Paris-Seine
2015-2016
Nestlé (France)
2014
Caffeine is a metabolite of great economic importance, especially in coffee, where it influences the sensorial and physiological impacts beverage. metabolism Coffea species begins with degradation purine nucleotides through three specific N-methyltransferases: XMT, MXMT DXMT. A comparative analysis was performed to clarify molecular reasons behind differences caffeine accumulation two species, namely arabica canephora var. robusta. Three different genes encoding N-methyltransferase were...
Macroautophagic degradation of sperm-inherited organelles prevents paternal mitochondrial DNA transmission in C. elegans. The recruitment autophagy markers around sperm mitochondria has also been observed mouse and fly embryos but their role is debated. Both worm Atg8 ubiquitin-like proteins, LGG-1/GABARAP LGG-2/LC3, are recruited after fertilization. Whereas LGG-1 depletion affects autophagosome function, stabilizes the substrates lethal, we demonstrate that LGG-2 dispensable for formation...
Abstract Prion-like domains (PLDs), defined by their low sequence complexity and intrinsic disorder, are present in hundreds of human proteins. Although gain-of-function mutations the PLDs neuronal RNA-binding proteins have been linked to neurodegenerative disease progression, physiological role range molecular functions still largely unknown. Here, we show that PLD Drosophila Imp, a conserved component ribonucleoprotein (RNP) granules, is essential for developmentally-controlled...
Abstract Background Chromosomes are subdivided spatially to delimit long-range interactions into topologically associating domains (TADs). TADs often flanked by chromatin insulators and transcription units that may participate in such demarcation. Remarkably, single-cell Drosophila TAD correspond dynamic heterochromatin nano-compartments can self-assemble. The influence of on compartmentalization remains unclear. Moreover, what extent fully compartmentalized away from active genes unclear...
Cell type-specific barcoding of genomes requires the establishment hundreds heterochromatin domains where heterochromatin-associated repressive complexes hinder chromatin accessibility thereby silencing genes. At heterochromatin–euchromatin borders, regulation not only depends on delimitation but may also involve interplays with nearby genes and their transcriptional activity, or alternatively histone modifiers, barrier insulators, more global demarcation chromosomes into 3D...
Macroautophagic degradation of sperm-inherited organelles prevents paternal mitochondrial DNA transmission in C. elegans. The recruitment autophagy markers around sperm mitochondria has also been observed mouse and fly embryos but their role is debated. Both worm Atg8 ubiquitin-like proteins, LGG-1/GABARAP LGG-2/LC3, are recruited after fertilization. Whereas LGG-1 depletion affects autophagosome function, stabilizes the substrates lethal, we demonstrate that LGG-2 dispensable for formation...