A5100655137- Plant Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- interferon and immune responses
- High voltage insulation and dielectric phenomena
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- Neurosurgical Procedures and Complications
- Glaucoma and retinal disorders
- Melanoma and MAPK Pathways
- Substance Abuse Treatment and Outcomes
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Groundwater and Isotope Geochemistry
- Retinal Imaging and Analysis
- Marine and coastal ecosystems
- Transplantation: Methods and Outcomes
- Digital Imaging for Blood Diseases
- Invertebrate Immune Response Mechanisms
Qianjiang Central Hospital
2018-2025
Sun Yat-sen University
2022-2024
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2024
Jilin University
2022-2023
Nanjing University of Chinese Medicine
2023
First Hospital of Jilin University
2022-2023
Qingdao University
2023
Qingdao Municipal Hospital
2023
Radar (United States)
2023
Jiangsu University
2022
Abstract Background Migraine, a widespread neurological condition, substantially affects the quality of life, particularly for adolescents and young adults. While its impact is significant, there remains paucity comprehensive global research on burden migraine in younger demographics. Our study sought to elucidate prevalence, incidence, disability-adjusted life-years (DALYs) associated with 15–39 age group from 1990 2021, utilizing data Global Burden Disease (GBD) 2021 study. Methods...
A conjugated small molecule incorporating binary electron-deficient units was applied in all-small-molecule organic solar cells using fullerene or non-fullerene derivatives as the electron acceptor.
ABSTRACT RNA interference (RNAi) is a eukaryotic gene-silencing mechanism that functions in antiviral immunity diverse organisms. To combat RNAi-mediated immunity, viruses encode viral suppressors of silencing (VSRs) target and protein components the RNAi machinery. Although endonuclease Dicer plays key roles little known about how VSRs Dicer. Here, we show B2 from Wuhan nodavirus (WhNV), counterpart Flock House virus (FHV), suppresses Drosophila melanogaster by directly interacting with...
Dicer-2 is the central player for small interfering RNA biogenesis in Drosophila interference (RNAi) pathway. Intriguingly, we found that has an unconventional RNAi-independent function positively modulates Toll immune signaling, which defends against Gram-positive bacteria, fungi, and some viruses, both cells adult flies. The loss of expression makes fruit flies more susceptible to fungal infection. We further revealed posttranscriptionally signaling because required proper protein but not...
ABSTRACT RNA-remodeling proteins, including RNA helicases and chaperones, act to remodel structures and/or protein-RNA interactions are required for all processes involving RNAs. Although many viruses encode their in vitro activities roles infected cells largely remain elusive. Noroviruses a diverse group of positive-strand the family Caliciviridae constitute significant potentially fatal threat human health. Here, we report that protein NS3 encoded by norovirus has both ATP-dependent...
Aluminum (Al) is one of the key parameters GEOTRACES. In spring 2011, we examined distribution dissolved Al in East China Sea (ECS) to assess potential passage coastal water across shelf western Pacific. Measurement coastal, shelf, and break waters indicated decreasing concentrations with distance from coast. However, northward increase upper 100 m along transect, corresponding flow Kuroshio Water Okinawa Trough north Taiwan Tokara strait, indicates contributions terrestrial material. The...
Wuhan nodavirus (WhNV) is a newly identified member of the Nodaviridae family with bipartite genome positive-sense RNAs. A nonstructural protein encoded by subgenomic RNA3 nodaviruses, B2, serves as potent RNA silencing suppressor (RSS) sequestering duplexes. We have previously demonstrated that WhNV B2 blocks in cultured Drosophila cells. However, molecular mechanism which functions remains unknown. Here, we successfully established an system cells derived from Pieris rapae, natural host...
To investigate the risk factors of lower limb amputation, and help physicians better understand clinical characteristics patients with diabetic foot, make treatment strategies for these correctly.In this study, inpatients foot treated in our hospital form January 2013 to February 2021 were reviewed retrospectively. The divided into amputation conservative groups. variables patients, consisting age, gender, smoking history, alcohol use, diabetes ulcer duration, size, Wagner classification,...
Osteosarcoma is the second leading cause of cancer‑associated mortality worldwide in children and adolescents. ZC3H12D has been shown to negatively regulate Toll‑like receptor signaling serves as a possible tumor suppressor gene. MicroRNAs (miRNAs/miRs) are known play an important role proliferation human osteosarcoma cells. However, whether miRNAs can affect development by regulating expression not yet investigated. The aim present study was investigate miR128‑3p expression, well its...
Background Intracerebral hemorrhage is the most disabling and lethal form of stroke. We aimed to develop a novel clinical score for neurological deterioration during hospitalization after intracerebral hemorrhage. Methods Results analyzed data from CHERRY (Chinese Cerebral Hemorrhage: Mechanism Intervention) study. Two‐thirds eligible patients were randomly allocated into training cohort (n=1027) one‐third validation (n=515). Multivariable logistic regression was used identify factors...
ABSTRACT Picorna-like viruses in the Picornavirales order are a large group of positive-strand RNA that include numerous important pathogens for plants, insects, and humans. In these viruses, nonstructural protein 2C is one most conserved proteins contains ATPase activity putative helicase activity. Here we expressed Ectropis obliqua picorna-like virus (EoV; genus Iflavirus , family Iflaviridae ) eukaryotic expression system determined EoV displays ATP-independent nucleic acid helix...
Abstract For double-stranded RNA (dsRNA) viruses in the family Reoviridae, their inner capsids function as machinery for viral (vRNA) replication. Unlike other multishelled reoviruses, cypovirus has a single-layered capsid, thereby representing simplified model studying vRNA replication of reoviruses. VP5 is one three major capsid proteins and functions clamp protein to stabilize capsid. Here, we expressed from type 5 Helicoverpa armigera (HaCPV-5) eukaryotic system determined that this...
Nodaviruses are a family of positive-stranded RNA viruses with bipartite genome RNAs. In nodaviruses, genomic RNA1 encodes protein A, which is recognized as an RNA-dependent polymerase (RdRP) and functions the sole viral replicase responsible for its replication. Although nodaviral replication has been studied in considerable detail, nodaviruses well models investigating replication, mechanism(s) governing initiation synthesis have not determined. this study, we characterized RdRP activity...
The N-end rule pathway is an evolutionarily conserved proteolytic system that degrades proteins containing N-terminal degradation signals called N-degrons, and has emerged as a key regulator of various processes. Viruses manipulate diverse host pathways to facilitate viral replication evade antiviral defenses. However, it remains unclear if infection any impact on the pathway. Here, using picorna-like virus model, we found promoted accumulation caspase-cleaved Drosophila inhibitor apoptosis...
Despite similar material composition and insulation application, the alternating current (AC) cross-linked polyethylene (XLPE) direct (DC) XLPE materials cannot replace each other due to different voltage forms. Herein, this work presents a systematical investigation into effects of thermal aging on properties 500 kV-level commercial AC DC materials. A higher content antioxidants in than was experimentally demonstrated via analysis technologies, such as oxidation-induced time temperature....
This study aimed to quantify the global stroke burden attributable low physical activity and high body mass index in adults aged ≥55 years using data from Global Burden of Disease 2019 study.
Objective: Endometriosis is a chronic inflammatory estrogen-dependent disease with the growth of endometrial tissues outside uterine cavity. Nevertheless, etiology endometriosis still unclear. Integrated bioinformatics analysis was implemented to reveal molecular mechanisms underlying this disease. Methods: A total four gene expression datasets (GSE7305, GSE11691, GSE23339, and GSE25628) were retrieved from GEO, which merged into meta-dataset, followed by removal batch effects via sva...
ABSTRACT Nodaviruses are small nonenveloped spherical viruses with a bipartite genome of RNAs. In nodaviruses, subgenomic RNA3 (sgRNA3) plays critical role in viral replication and survival, as it coordinates the two genomic RNAs (RNA1 RNA2) encodes protein B2, which is potent RNA-silencing inhibitor. Despite its importance, molecular mechanism nodaviral sgRNA3 synthesis still poorly understood. Here, we propose that Wuhan nodavirus (WhNV) internally initiated from promoter on negative...
Flock House virus (FHV) is a positive-stranded RNA with bipartite genome of RNAs, RNA1 and RNA2, belongs to the family Nodaviridae. As most extensively studied nodavirus, FHV has become well-recognized model for studying various aspects virology, particularly viral replication antiviral innate immunity. encodes protein A, which an RNA-dependent polymerase (RdRP) functions as sole replicase responsible replication. Although been in considerable detail, mechanism employed by A initiate...
The interface of multi-layer insulation is a relatively weak point in the cable system during long-term high-temperature service. Space charge prone to continuously accumulate area, leading deterioration electrical properties and even failure advance. knowledge about thermal oxidation polyethylene (PE) materials at molecular level still urgent explore. Herein, single-layer double-layer PE insulation, representing typical structure frequency-shift pulse voltage track cables, were prepared...