A5100406021- Hydrogen's biological and therapeutic effects
- Aquaculture Nutrition and Growth
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Aquaculture disease management and microbiota
- Shoulder Injury and Treatment
- Fish Biology and Ecology Studies
- Transplantation: Methods and Outcomes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Congenital gastrointestinal and neural anomalies
- Animal Genetics and Reproduction
- Endometriosis Research and Treatment
- Digestive system and related health
- Anesthesia and Neurotoxicity Research
- Physiological and biochemical adaptations
- Endometrial and Cervical Cancer Treatments
- Telomeres, Telomerase, and Senescence
- Reproductive biology and impacts on aquatic species
- Genetic and phenotypic traits in livestock
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- Head and Neck Anomalies
- Biochemical effects in animals
- Inflammasome and immune disorders
- MicroRNA in disease regulation
Stomatology Hospital
2025
Xi'an Jiaotong University
2025
China Medical University
2014-2024
Chinese Academy of Sciences
2024
Institute of Zoology
2024
State Key Laboratory of Stem Cell and Reproductive Biology
2024
University of Chinese Academy of Sciences
2024
Chinese Academy of Fishery Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
First Hospital of Xi'an
2024
All-RNA-mediated targeted gene integration methods, rendering reduced immunogenicity, effective deliverability with non-viral vehicles, and a low risk of random mutagenesis, are urgently needed for next-generation addition technologies. Naturally occurring R2 retrotransposons hold promise in this context due to their site-specific profile. Here, we systematically analyzed the biodiversity elements screened several orthologs capable full-length insertion mammalian cells. Robust system...
In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT could reverse decreasing trend body weight, thymus/spleen index and hematological parameters CTX. Compared with immunosuppressive CTX, enhance NK cytotoxicity, macrophage phagocytosis, T lymphocyte proliferation, regulate proportion cell subsets mesenteric lymph nodes (MLN), promote production secretory...
The composition and content of fatty acids (FAs) amino (AAs) are important nutritional sensory traits in aquaculture fish. To meet increasing demand while retaining quality, genetic selection breeding programs is urgently needed to improve these traits. In this study, we performed the genome-wide association study (GWAS) identify variants candidate genes potentially linked FA AA compositions grass carp muscle. We focused on key dietary components, including unsaturated FAs essential AAs....
Hydrogen-rich saline (HRS) has a protective effect on sepsis-induced lung injury. However, the underlying mechanisms are still unclear. Polarization and apoptosis of macrophages essential factors in pathogenesis acute injury (ALI). Moreover, autophagy is involved regulation both macrophage polarization apoptosis. Therefore, this study investigated ability HRS to attenuate ALI through alveolar (AMs) during sepsis by modulating autophagy.Male Sprague-Dawley (SD) rats were used prepare animal...
INTRODUCTION Existing research suggests an association between smoking and the incidence of recurrent aphthous stomatitis (RAS); however, causal relationship remains ambiguous.We employed Mendelian randomization (MR) to clarify potential risk developing RAS.METHODS We utilized genome-wide study (GWAS) sequencing data related from Finnish database as instrumental variables (IVs) GWAS for RAS UK Biobank (UKB) outcome perform a two-sample MR analysis.The selection IVs was rigorously controlled...
ABSTRACT The anterior cruciate ligament (ACL) is known to have a poor healing ability, especially in comparison with the medial collateral ligament, which can heal relatively well. In this study, we detected significant increases mRNA levels of multiple matrix metalloproteinases (MMPs) (MMP‐1, ‐2, ‐7, ‐9, ‐11, ‐14, ‐17, ‐21, ‐23A, ‐24, ‐25, ‐27, and ‐28) tissue inhibitors (TIMPs) (TIMP‐1, ‐3, ‐4) ACL fibroblasts after an vitro injury equi‐biaxial stretch chamber. However, only some MMPs...
The residual laxity after transtibial posterior cruciate ligament (PCL) reconstruction has been reported by several authors. sharp angle where the graft exits tibial tunnel, which is known as "killer turn", believed to be main reason. purpose of this study was reveal mechanism turn" and its effect on both tunnel inlet. A total 60 New Zealand white rabbits were included. All PCL reconstructions performed in vitro using Achilles tendon autograft. cyclic loading tests conducted when...
Female common carp grow faster than male individuals, implying that rearing females could be more profitable in aquaculture. Non-coding RNAs (ncRNAs) serve as versatile regulators with multiple functions diverse biological processes. However, the roles of ncRNAs sex differentiation are less studied. In this study, we investigated expression profiles ncRNAs, including miRNAs, lncRNAs, and circRNAs, gonads to comprehend carp. A substantial number differentially expressed (DE) ovaries testes...
DNA methylation and chromatin accessibility play important roles in gene expression, but their function subgenome expression dominance remains largely unknown. We conducted comprehensive analyses of the transcriptome, methylation, liver muscle tissues allotetraploid common carp, aiming to reveal epigenetic modifications dominance. A noteworthy overlap differential expressed genes (DEGs) as well functions was observed across two subgenomes. In promoter body, level B significantly different...
The Northern snakehead (
Aging is an irreversible progressive decline in physical function. Graves' disease (GD) a common cause of hyperthyroidism and characterized by elevated levels the thyroid hormone (TH). High TH are associated with aging shortened lifespan. The causal relationship between GD has yet to be investigated. We used genome-wide association study (GWAS) datasets Mendelian randomization (MR) analysis explore link aging. To assess statistical power instrumental variables (IVs), F-statistics R2 were...
Objective To explore the mechanism of “killer turn”, which is reported to be a reason for postoperative residual laxity after transtibial posterior cruciate ligament ( PCL ) reconstruction, in low bone mineral density BMD condition. Methods A total 80 skeletally mature female N ew Z ealand white rabbits were included biomechanical evaluation reconstructions. The subjects equally divided into n = 40) and control groups 40). Rabbits group treated with surgery drug injection establish an...
<b><i>Purpose:</i></b> The aim of this study was to determine the expression <i>Cdx4 </i>(caudal-type homeobox gene-4) during anorectal development in normal and ethylenethiourea (ETU)-induced malformation (ARM) embryos with a view establishing possible role </i>in ARM pathogenesis. <b><i>Materials Methods:</i></b> induced by ETU on 10th gestational day (GD10) rat embryos. Cesarean deliveries were then performed harvest...
Background Metabolic dysregulation represents a defining characteristic of Type 2 diabetes (T2DM). Nevertheless, there remains an absence substantial evidence establishing direct causal link between circulating blood metabolites and the promotion or prevention T2DM. In addressing this gap, we employed Mendelian randomization (MR) analysis to investigate potential association 1,091 metabolites, 309 metabolite ratios, occurrence Methods Data encompassing single-nucleotide polymorphisms (SNPs)...