A5101740014- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Dermatology and Skin Diseases
- Cutaneous Melanoma Detection and Management
- AI in cancer detection
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Infectious Diseases and Tuberculosis
- Tumors and Oncological Cases
- Digital Imaging for Blood Diseases
- IL-33, ST2, and ILC Pathways
- Medical Imaging Techniques and Applications
- Selenium in Biological Systems
- Intraocular Surgery and Lenses
- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
- Urinary Bladder and Prostate Research
- Diverticular Disease and Complications
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Vascular Malformations Diagnosis and Treatment
Ruijin Hospital
2012-2025
Institute of Immunology
2025
Shanghai Jiao Tong University
2014-2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
Yantai Nanshan University
2024
Hunan Normal University
2023
Affiliated Hospital of Qingdao University
2020
Qingdao University
2020
Shanghai Ninth People's Hospital
2007
Pemphigus is a complex dermatologic autoimmune bullous disease whose pathogenic mechanism not fully understood. Anti-desmoglein-1 (Dsg1) and anti- Dsg3 autoantibodies play an important role in the pathogenesis of pemphigus. To investigate T-helper17 (Th17) regulatory T (Treg) cells pemphigus fifty-one patients twenty-six healthy individuals (control group). Levels CD3(+)CD8(-) IL-17 expressing Th CD4(+)CD25(hi)Foxp3(+) Treg were determined by FACS both groups, along with anti-Dsg1 antibody...
Abstract Pemphigus is an autoimmune skin disease. Ectopic lymphoid-like structures (ELSs) were found to be commonly present in the pemphigus lesions, presumably supporting situ desmoglein (Dsg)-specific antibody production. Yet functional phenotypes and regulators of Lymphoid aggregates lesions remain largely unknown. Herein, we used microarray technology profile gene expression lesion infiltrating mononuclear cells (SIMC) from patients. On top that, compared SIMC dataset peripheral blood...
Selenium (Se), a well-known antioxidant, is important for male fertility and sperm quality. The gut microbiota involved in vital activities cross-talk between reproduction the axis. It still unclear whether mediates impact of selenium on semen quality, what underlying mechanisms may be. A selenized glucose (SeGlu) derivative novel organic Se compound. After 7 days acclimation, Sprague-Dawley (SD) rats (230 g, 6 weeks) were divided into three drinking groups: deionized water group (CK), SeGlu...
To compare the efficiency of scleral buckling (SB) and pars plana vitrectomy (PPV) with or without SB in patients primary simple phakic fovea-splitting rhegmatogenous retinal detachment (RRD). A retrospective case-control study included 101 aged <55 years diagnosed RRD. The outcome was functional success, defined as achieving a postoperative logarithm minimum angle resolution best-corrected visual acuity 0.3 better at 6 months post-surgery. Secondary outcomes final anatomical success...
We would like to present a case of 41-year-old man with LABD complicated UC, who experienced an outbreak skin lesions upon the use infliximab, as well persistent intestinal symptoms. Upadacitinib markedly alleviated his diarrhoea and pruritus, led regression lesions. This suggests potential JAK inhibitors in treating LABD, especially patients concomitant autoinflammatory disorders.
Abstract Background Pemphigus is a life-threatening autoimmune disease mediated by anti-desmoglein(Dsg) autoantibodies. Ectopic lymphoid-like structures (ELSs) are frequently found in chronic skin lesions and thought to contribute local autoantibody production. However, the mechanisms driving ELS formation at lesion sites remain unclear. Objectives To investigate role of myeloid cells ELSs pemphigus identify potential therapeutic targets better understanding underlying that this process....
Abstract Due to the long disease duration, impact on appearance, social stigmatization, and numerous side effects of treatment, pemphigus, an autoimmune bullous disease, often has a significant psychological patients. On other hand, mood disorders may exacerbate by affecting patient's self‐management, forming vicious circle. To investigate anxiety depressive in patients with total 140 pemphigus were recruited for this cross‐sectional retrospective study between March 2020 January 2022. A...
Purpose: Direct immunofluorescence (DIF) on frozen sections (DIF-F) plays a key role in the identification and differential diagnosis of bullous dermatoses, which are group critical autoimmune diseases that include pemphigus, pemphigoid (BP), epidermolysis bullosa acquisita (EBA). However, this technique requires specialized laboratory equipment conditions, sample acquisition preservation. In study, application value DIF paraffin-embedded tissue (DIF-P) detecting IgG using heat-induced...
Abstract is missing (Short communication)
Nitidine chloride (NC) has displayed anti-tumor effects in various types of cancer. However, the role NC human melanoma is largely unknown. This study aimed to investigate on cancer cells A375 and WM35 by MTT assay. Apoptosis was measured detecting caspase-3 protein expression level its activity. Autophagy TEM image, immunostaining immunoblotting assays. assays showed that significantly blocks proliferation. Immunoblotting activity inhibited proliferation inducing cell apoptosis. TEM, also...
Polar ice sheets, or cores, are among the most well-known natural archives that might provide crucial historical details about our planet's previous environment. An important factor in establishing fundamental characteristics of ice, likes pore close-off, albedo, melt events, is ice-core microstructure. To engulf these complications Ice-Core Micro-CT Image Segmentation with Dual Stream Spectrum Deconvolution Neural Network and Gaussian Mixture Model (ICMCTS-WSOA-DSSDNN-GMM)is proposed....