A5057882828- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
- HIV/AIDS drug development and treatment
- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- Myasthenia Gravis and Thymoma
- Viral Infections and Outbreaks Research
- Agriculture and Rural Development Research
- Nosocomial Infections in ICU
- Data-Driven Disease Surveillance
- Tracheal and airway disorders
- COVID-19 diagnosis using AI
- RNA and protein synthesis mechanisms
- HIV/AIDS Research and Interventions
- Glycosylation and Glycoproteins Research
- Viral gastroenteritis research and epidemiology
- Antibiotic Use and Resistance
- COVID-19 and healthcare impacts
- Plant Virus Research Studies
- Cystic Fibrosis Research Advances
Hamad Medical Corporation
2021-2024
Tunis El Manar University
2021
Children's Hospital
2021
Faculté de médecine de Tunis
2016
Hôpital Charles-Nicolle
2013-2016
Tunis University
2016
National Influenza Center
2012
The study objective was to the assess level of detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in urban population Qatar. Antibody testing performed on residual blood specimens for 112,941 individuals (∼10% Qatar's population) attending routine/other clinical care between May 12 and September 9, 2020. Seropositivity 13.3% (95% confidence interval [CI] = 13.1–13.6%) independently associated with sex, age, nationality, encounter type, date. Median optical...
Overall effectiveness of infection in preventing reinfection with SARS-CoV-2 JN.1 variant was estimated at 1.8% (95% CI: −9.3to 12.6%), and demonstrated rapid decline over time since the previous infection, decreasing from 82.4% 40.9 to 94.7%) within 3 less than 6 months, a negligible level after one year.
This study was initiated to evaluate, for the first time, performance and quality of influenza-like illness (ILI) surveillance system in Tunisia. The evaluation covered period 2012–2015 used different data sources measure indicators related completeness, representativeness, timeliness, simplicity, acceptability, flexibility, stability utility. During period, 485.221 ILI cases were reported among 6.386.621 outpatients at 268 sentinel sites. To conserve resources, only enrolled tested...
The data contribute to a better understanding of the circulation influenza viruses especially in North-Africa.The objective this surveillance was detect severe cases, identify their epidemiological and virological characteristics assess impact on healthcare system.We describe report findings laboratory-based human cases virus other respiratory viruses' infection during three seasons Tunisia.The 2008-09 winter season is underway Tunisia, with co-circulation A/H3N2 (56.25%), A(H1N1) (32.5%),...
Introduction. The cycle threshold (Ct) value in real-time PCR (RT-PCR) is where a target-specific amplification signal becomes detectable and can infer viral load, risk of transmission recovery. Use Ct values routine practice uncommon.Gap Statement. There lack use when reporting RT-PCR results practice.Aim. To automatically insert interpretive comments SARS-CoV-2 to improve patient management.Methodology. Routine across three different platforms were reviewed for concordance at presentation...
We present major results concerning isolation and determination of the nucleotide sequence hemagglutinin (HA1) pandemic (H1N1)pdm09 influenza viruses found in Tunisia. Amino acid analysis revealed minor amino changes antigenic or receptor-binding domains. mutations that were also 1918 virus, which includes S183P 4 S185T mutation 19 27 analyzed from 2011, while none 2009 carried these mutations. Also two specific differences into N-glycosylation sites (N288T N276H) detected. The phylogenetic...
In this study we report the prevalence of antiretroviral drug resistant HIV-1 genotypes virus isolated from Djiboutian patients who failed first-line therapy (ART) and ART naïve patients. A total 35 blood samples 16 showed failure (>1000 viral genome copies/ml) 19 ART-naïve were collected in Djibouti October 2009 to December 2009. Both protease (PR) reverse transcriptase (RT) genes amplified sequenced using National Agency for AIDS Research (ANRS) protocols. The Stanford HIV database...
In this study, the genetic diversity of HIV-1 in Tunisia was analyzed. For this, 193 samples were collected different regions between 2012 and 2015. A protease reverse transcriptase fragment amplified sequenced. Phylogenetic analyses performed through maximum likelihood recombination analyzed by bootscanning. Six subtypes (B, A1, G, D, C, F2), 5 circulating recombinant forms (CRF02_AG, CRF25_cpx, CRF43_02G, CRF06_cpx, CRF19_cpx), 11 unique identified. Subtype B (46.4%) CRF02_AG (39.4%)...
ABSTRACT Background Qatar has experienced a large SARS-CoV-2 epidemic. Our first objective was to assess the proportion of urban population that been infected with SARS-CoV-2, by measuring prevalence detectable antibodies. second identify predictors for infection and having higher antibody titers. Methods Residual blood specimens from individuals receiving routine other clinical care between May 12-September 9, 2020 were tested anti-SARS-CoV-2 Associations seropositivity titers identified...
The novel pandemic A (H1N1) pdm09 virus was first identified in Mexico April 2009 and since then it spread worldwide over a short period of time. Although the infection is generally associated with mild disease relatively low mortality, projected that mutations specific regions viral genome, especially within receptor binding domain haemagglutinin (HA) protein could result more virulent stains, leading to severe pathogenicity.To monitor genetic polymorphisms at position 222 Haemagglutinin...
The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012. objective of the study was to describe epidemiology, risk factors, clinical characteristics, and outcome MERS-CoV Qatar. A total 28 cases were identified, corresponding an incidence 1.7 per 1,000,000 population. Most patients had a history contact with camels 15, travel Kingdom Saudi Arabia 7 or known individuals confirmed infection 7. Majority acute kidney injury (AKI) 17 9 needed renal replacement therapy. All...
Introduction The Cycle Threshold (CT) value in Real-time Polymerase Chain Reaction (RT-PCR) is where a target specific amplification signal becomes detectable and can infer viral load, risk of transmission recovery SARS-CoV-2 infections. Adoption into routine practice however uncommon. Gap Statement lack inclusion CT values when reporting RT-PCR results practice. Aim To use Qatar to aid clinical interpretation patient management. Methodology Routine across 3 different platforms were reviewed...
Introduction. The frequency of multidrug-resistant organisms (MDROs) in hospitals and the risk delaying effective treatment result culture respiratory secretions for nearly all patients with suspected pneumonia. Culture delays contribute to over prescribing use broader spectrum antibiotics. Gap statement. need improved rapid diagnostics early assessment hospital Aim. To validate a new metric, enhanced Gram stain (EGS), provide diagnostic test high accuracy that could be assessed clinical...
Abstract This study investigated the effectiveness of natural infection in preventing reinfection with JN.1 variant during a large wave Qatar, using test-negative case-control design. The overall previous was estimated at only 1.8% (95% CI: −9.3-12.6%). demonstrated rapid decline over time since infection, decreasing from 82.4% 40.9-94.7%) within 3 to less than 6 months after 50.9% −11.8-78.7%) subsequent months, and further dropping 18.3% −34.6-56.3%) months. Ultimately, it reached...
This study investigated the performance of a rapid point-of-care antibody test, BioMedomics COVID-19 IgM/IgG Rapid Test, in comparison with high-quality, validated, laboratory-based platform, Roche Elecsys Anti-SARS-CoV-2 assay. Serological testing was conducted on 709 individuals. Concordance metrics were estimated. Logistic regression used to assess associations seropositivity. SARS-CoV-2 seroprevalence 63.5% (450/709; 95% CI 59.8%-67.0%) using assay and 71.9% (510/709; 68.5%-75.2%) There...
Abstract Objective To investigate the performance of a rapid point-of-care antibody test, BioMedomics COVID-19 IgM/IgG Rapid Test, in comparison with high-quality, validated, laboratory-based platform, Roche Elecsys Anti-SARS-CoV-2 assay. Methods Serological testing was conducted on 708 individuals. Concordance metrics were estimated. Logistic regression used to assess associations seropositivity. Results SARS-CoV-2 seroprevalence 63.4% (449/708; 95% CI 59.8%-66.9%) using assay and 71.9%...
Rhinoviruses (RV) are a major cause of Severe Acute Respiratory Infection (SARI) in children, with high genotypic diversity different regions. However, RV type remains unknown several regions the world. In this study, genetic variability frequently circulating types Northern Tunisia was investigated, using phylogenetic and phylogeographic analyses specific focus on most frequent types: RV-A101 RV-C45. This study concerned 13 Tunisia. They were obtained from respiratory samples collected 271...