A5029428902- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- MRI in cancer diagnosis
- Eosinophilic Esophagitis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Gastroesophageal reflux and treatments
- Metastasis and carcinoma case studies
- Pancreatitis Pathology and Treatment
- Ultrasound and Hyperthermia Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Inflammatory mediators and NSAID effects
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Gastrointestinal disorders and treatments
- Systemic Lupus Erythematosus Research
- Ovarian cancer diagnosis and treatment
- Esophageal and GI Pathology
- Urinary Tract Infections Management
Wakayama Rosai Hospital
2018-2025
Wakayama Medical University
2009-2018
Center for HIV and Hepatogastroenterology
2008
We conducted a longitudinal cohort study to determine the association of Helicobacter pylori infection and progression chronic atrophic gastritis (CAG) with gastric cancer. A 4655 healthy asymptomatic subjects was followed for mean period 7.7 years. H. established by serum specific antibodies presence CAG confirmed pepsinogen. During follow-up period, 45 cancer cases were detected (incidence rate, 126/100000 person-years). univariate analysis after adjustment age showed that both...
Our study investigated the relationship between gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis or resulting atrophic (CAG). A cohort 4,655 healthy asymptomatic subjects, in whom serum pepsinogen (PG) H. pylori antibody titer had been measured to assess stage gastritis, was followed for up 16 years, investigated. In subjects with a serologically diagnosed stomach (H. pylori-negative/CAG-negative), incidence rate low, at 16/100,000 person-years....
Objective The purpose of this study was to evaluate the usefulness contrast-enhanced ultrasonography (CEUS) in diagnosis solid renal tumors. Methods Twenty-nine patients with tumors detected on gray scale underwent resection for suspected malignancy. Findings arterial phase contrast computed tomography (CT) and CEUS were compared each diagnosis. Results Histopathologic examination resected lesions showed malignancy 26 (clear cell carcinoma, n = 18; papillary 6; collecting duct 1;...
Abstract A longitudinal cohort study was conducted in Helicobactor pylori‐ infected middle‐aged Japanese males to evaluate the preventive effects of H. pylori eradication on development gastric cancer according extent chronic atrophic gastritis (CAG). The CAG monitored by baseline serum pepsinogen (PG) levels. We followed 3,656 subjects with persistent infection and 473 successful for a mean (SD) 9.3 (0.7) years. Groups without extensive were categorized based PG test‐positive criteria...
Abstract Background: Gastric cancer screening using the pepsinogen filter test is receiving wide recognition in Japan owing to convenience, freedom from discomfort or risk, efficiency, and economy. Because long-term outcomes of development extensive atrophic gastritis detected by are unclear, test-positive test-negative subjects were investigated a longitudinal cohort study. Methods: Subjects comprised 5,209 middle-aged men with measured serum levels who followed for 10 years. Cancer based...
The aim of this study was to evaluate the ability contrast-enhanced endoscopic sonography for discrimination mural nodules from mucous clots in intraductal papillary mucinous neoplasms pancreas.Contrast-enhanced performed 17 consecutive patients who had an neoplasm with lesions. To perform sonography, we used a second-generation sonographic contrast agent. After reconstitution 2 mL sterile water injection, 0.7 agent administered through peripheral vein. From 10 30 seconds after injection...
This study aimed to elucidate groups at high risk of developing cancer among patients with serologically identified Helicobacter pylori infection and nonatrophic stomach. Annual endoscopy was performed for a mean 5.4 years in 496 asymptomatic middle-aged men who were H. antibody-positive pepsinogen (PG) test-negative. Subjects stratified according the activity pylori-associated gastritis measured by serum levels PG antibody, and/or endoscopic findings rugal hyperplastic (RHG), development...
Thrombocytopenia represents an obstacle for invasive procedures in chronic liver disease (CLD) patients. We aimed to estimate the appropriate dose and evaluate efficacy safety of lusutrombopag treatment thrombocytopenia before percutaneous radiofrequency ablation (RFA) primary hepatic cancer patients with CLD.In this multicenter, randomized, double-blind, placebo-controlled study conducted Japan, 61 CLD platelet count < 50 × 103/µL at screening were randomized placebo or 2, 3, 4 mg once...
A total of 5,209 asymptomatic, middle-aged subjects, whose serum pepsinogen (PG) and Helicobacter pylori antibody levels had been assessed, were followed for 10 years. Subjects with positive H. antibodies (>50 U/mL) an increased cancer risk (HR = 3.48, 95% CI 1.26-9.64). Risk gastric as the level increased; pylori-positive group >500 U/mL highest incidence rate (325/100,000 person-years). Cancer development also a reduced PG I or I/II ratio; was significantly elevated <or=30 ng/mL 3.54,...
This study investigated correlations between Helicobacter pylori infection or chronic atrophic gastritis (CAG) and risk of colorectal adenoma in a population-based case-control study. Subjects comprised asymptomatic, middle-aged, male Japanese factory workers who participated an annual health check-up program, including cancer screening with colonoscopy. We selected 239 cases based on histological evaluation age-matched adenoma-free controls, evaluated according to stage H. pylori-related as...
Lansoprazole is a potent anti-gastric ulcer drug that inhibits gastric proton pump activity. We identified novel function for lansoprazole, as an inducer of anti-oxidative stress responses in the liver. Gastric administration lansoprazole (10–100 mg/kg) to male Wistar rats produced dose-dependent increase hepatic mRNA levels nuclear factor, erythroid-derived 2, -like 2 (Nrf2), redox-sensitive transcription at 3 h and Nrf2 immunoreactivity (IR) whole lysates 6 h. Conversely, Kelch-like...
Objectives . To investigate the usefulness of contrast-enhanced endoscopic ultrasonography (CE-EUS) for histological differentiation pancreatic tumors. Methods CE-EUS was performed consecutive patients having a solid lesion, and tumors were classified into three vascular patterns (hypervascular, isovascular, hypovascular) at two time phases (early-phase late-phase). Correlation between histopathology resected cancer (PC) tissues ascertained. Results The final diagnoses 147 examined...
ABSTRACT Background The aim of this study was to elucidate the histologic and clinical implications detection intratumoral vessels on contrast‐enhanced endoscopic ultrasonography (CE‐EUS) in gastrointestinal stromal tumors (GISTs). Methods Thirteen patients with a GIST, all whom were referred for surgery, underwent presurgical CE‐EUS. malignant potential, assessed according modified Fletcher risk classification system, degree angiogenesis compared presence or absence Results Of six observed...
The preventive effect of Helicobacter pylori (HP) eradication on metachronous gastric cancer development after endoscopic resection remains controversial. aim this study was to identify specific features that correlated with the risk submucosal dissection (ESD) using both findings before ESD and changes HP eradication.This retrospective investigated 122 consecutive patients who underwent for early successful ESD. Endoscopic linked were evaluated according cancer.Most showed severe atrophy...
With the aim of developing more efficient gastric cancer screening programs for use in Japan, we studied a new program that combines serum pepsinogen (PG) testing and barium digital radiography (DR). A total 17 647 middle‐aged male subjects underwent workplace over 7‐year period using combination PG DR. This program's effectiveness, as well other characteristics program, was analyzed. Forty‐nine cases were detected (comprising 88% early cases). The detection rate 0.28%, positive predictive...
To clarify the clinical features of and risk factors for extrahepatic seeding, a major complication following radiofrequency ablation (RFA) hepatocellular carcinoma (HCC). Our prospective database 351 nodules in 257 patients with HCC who had undergone RFA between April 2001 2008 was reviewed. The variables were assessed to identify seeding: age, sex, viral markers, Child-Pugh class, tumor size, number tumors, indication (tumor size ≤3 cm, tumors ≤3), biopsy prior RFA, degree histological...
Objective This study aimed to evaluate the prognostic ability of lens culinaris-agglutinin-reactive fraction alpha-fetoprotein (AFP-L3) in atezolizumab plus bevacizumab combination therapy (ATZ/BV) for unresectable hepatocellular carcinoma (u-HCC). Methods The analysis included 78 u-HCC patients who were evaluated early tumor response after 6 weeks ATZ/BV. Positivity markers (TMs), including AFP, AFP-L3, and des-gamma-carboxy prothrombin (DCP), was defined as elevated values AFP (≥100...
Contrast-enhanced endoscopic ultrasonography (CE-EUS) is a new imaging modality for pancreatic lesions. The aim of this study was to evaluate if CE-EUS useful predicting treatment efficacy before cancer chemotherapy by assessing intratumoral vessel flow.Thirty-nine patients with unresectable advanced underwent chemotherapy. were divided into 2 groups according the flow observed CE-EUS: sign-positive and sign-negative groups. Patient prognosis investigated presence or absence sign.Two...
Percutaneous radiofrequency ablation (RFA) is a well-established local treatment for small hepatocellular carcinoma (HCC). However, poor differentiation risk factor tumor seeding or intrahepatic dissemination after RFA HCC. The present study aimed to develop method predicting poorly differentiated HCC using contrast computed tomography (CT) safe and effective RFA.Of HCCs diagnosed histologically, 223 patients with 226 showing enhancement on CT were analyzed. pattern was classified into two...