A5015915011- Healthcare and Venom Research
- Plant-based Medicinal Research
- Pluripotent Stem Cells Research
- vaccines and immunoinformatics approaches
- Malaria Research and Control
- Mosquito-borne diseases and control
- Tissue Engineering and Regenerative Medicine
- Antimicrobial Peptides and Activities
- Neurogenesis and neuroplasticity mechanisms
- Biochemical and Structural Characterization
- Retinal Development and Disorders
- COVID-19 Clinical Research Studies
- Corneal Surgery and Treatments
- Berberine and alkaloids research
- Infection Control and Ventilation
- Renal and related cancers
- Spine and Intervertebral Disc Pathology
- Electrospun Nanofibers in Biomedical Applications
- Sepsis Diagnosis and Treatment
- Medical and Biological Ozone Research
- SARS-CoV-2 detection and testing
- Technology and Data Analysis
- Piperaceae Chemical and Biological Studies
- Text and Document Classification Technologies
- SARS-CoV-2 and COVID-19 Research
Jawaharlal Nehru Medical College
2024
Centre for Cellular and Molecular Biology
2020-2023
Institute of Genomics and Integrative Biology
2021
Central Leather Research Institute
2021
Baker Hughes (United States)
2019
Dwarkadas J. Sanghvi College of Engineering
2018
D.Y. Patil University
2009
Abstract Background COVID-19 pneumonia has been associated with severe acute hypoxia, sepsis-like states, thrombosis and chronic sequelae including persisting hypoxia fibrosis. The molecular response pathway such pathologies our recent observations on anti-hypoxic anti-inflammatory effects of whole aqueous extract Adhatoda Vasica (AV) prompted us to explore its relevant preclinical mouse models. Methods In this study, we tested the effect AV, in murine models bleomycin induced pulmonary...
Corneal scarring and opacification are a significant cause of blindness affecting millions worldwide. The current standard care for corneal is transplantation, which suffers from several drawbacks. One alternative approach that has shown promise the use xenogeneic extracellular matrix (ECM), but its clinical applicability challenging due to safety concerns. This study reports innovative human cornea-derived ECM prevent post-traumatic scarring. About 30 - 40% corneas donated eye banks do not...
Corneal scarring is one of the major causes blindness, affecting millions worldwide. Despite recent advancements in surgical strategies, there an unmet need for a clinically feasible material and methods to prevent following corneal injury. In this study, we report potential utility hydrogel derived from cadaveric animal corneas, using decellularized matrix (abbreviated as dCMH), which prepared by simple method. This easily injectable, biocompatible, has ability maintain good shape-retention...
The COVID19 pandemic has led to multipronged approaches for treatment of the disease. Since de novo discovery drugs is time consuming, repurposing molecules now considered as one alternative strategies treat COVID19. Antibacterial peptides are being recognized attractive candidates viral infections. In this study, we describe anti-SARS-CoV-2 activity well-studied antibacterial gramicidin S and melittin obtained from Bacillus brevis bee venom respectively. EC
Viral infections have a history of abrupt and severe eruptions through the years in form pandemics. And yet, definitive therapies or preventive measures are not present. Herbal medicines been source various antiviral compounds such as Oseltamivir, extracted using shikimic acid from star anise (Illicium verum) Acyclovir Carissa edulis FDA (Food Drug Administration) approved drugs. In this study, we dissect anti-coronavirus infection activity Cissampelos pareira L (Cipa) extract an integrative...
Background Osteoarthritis (OA) is a chronic debilitating condition involving joints that ultimately leads to pain, restricted mobility, and functional impairment of the joint. The gold standard treatment end-stage OA arthroplasty. Following arthroplasty surgery, patients might have excruciating pain in postoperative period. Our study aimed evaluate beneficial effects multimodal drug cocktail who underwent surgery concerning knee range motion during healing Materials methods In this...
It is often perplexing for a person to decide which restaurant he must visit from huge range of available options.There have been numerous suggestion frameworks accessible issues like shopping, online video excitement, recreations, and so forth.Eateries Dining one territory where there major chance prescribe feasting choices clients in light their inclinations addition recorded information.By developing recommendation system could help user should visit, the can save lot his time, efforts...
An integration free iPSC line was generated from fibroblast obtained the skin of an aborted fetus in feeder conditions using episomal based vectors expressing pluripotency factors. The cell characterized and tested for both vitro vivo by teratoma formation differentiation into defined lineages brain organoids. Cell reported here is shown to be mycoplasma free.
Abstract Plug and Perf (P&P) still remains one of the most prolific methods used in multi-stage hydraulic fracturing operations. Recent changes materials chosen to manufacture frac plugs is leading increased efficiencies during installation as well plug milling phase P&P Historically, fluid diversion devises operations have been manufactured using mainly glass/epoxy based composite recent years, an effort increase efficiencies, disintegrating materials. Most efforts focused on...
Abstract Back ground Earlier studies suggested the use of dry swab method for SARS-CoV-2 detection as it does not need VTM and subsequent RNA extraction step making process cheaper, safer faster. In this study we explore whether virus in is viable can be cultured propagated. Method Swabs were spiked with stored three different conditions: a) (S D , eluted 1 mL DMEM), b) Viral Transport Medium ), c) Tris-EDTA buffer TE ). The sample groups either at room temperature (RT, 25°C±1°C) or 4°C 1,...
Abstract The COVID19 pandemic has resulted in multipronged approaches for treatment of the disease. Since de novo discovery drugs is time consuming, repurposing molecules now considered as one alternative strategies to treat COVID19. Antibacterial peptides are being recognized attractive candidates viral infections. In this study, we describe anti-SARS-CoV-2 activity gramicidin S and melittin obtained from Bacillus brevis bee venom respectively. Our vitro antiviral assay results showed...
Abstract Background: COVID-19 pneumonia has been associated with severe acute hypoxia, sepsis-like states, thrombosis and chronic sequelae including persisting hypoxia fibrosis. The molecular response pathway such pathologies our recent observations on anti-hypoxic anti-inflammatory effects of whole aqueous extract Adhatoda Vasica (AV) prompted us to explore its relevant preclinical mouse models. Methods: In this study, we tested the effect AV , in murine models bleomycin induced pulmonary...
The machine learning techniques are playing a major role in the field of immunoinformatics for DNA-binding domain analysis. Functional analysis binding ability protein antigen peptides to histocompatibility complex (MHC) class molecules is important vaccine development. variable length each peptide complicates this prediction. Such predictions can be used select epitopes use rational design and increase understanding roles immune system infectious diseases. Antigenic form Human papilloma...
In this research work, for the first time, we have developed and demonstrated a COVID-19 repellent coating on cotton cloth that not only repels virus but also most of human body fluids (superhemophobic). The was tested in BSL3 lab. controlled experiments revealed no significant increase log viral particles coated fabric compared to uncoated surface, evidence resisted SARS-CoV-2 inoculum. Further, exhibited excellent dust-free nature stain resistance against (blood, urine, bovine serum,...
Abstract Background Viral infections have a history of abrupt and severe eruptions through the years in form pandemics. And yet, definitive therapies or preventive measures are not present. Purpose Herbal medicines been source various antiviral compounds. An accelerated repurposing potential herbs can provide usable drugs identify druggable targets. In this study, we dissect anti-coronavirus activity Cissampelos pareira L ( Cipa ). using an integrative approach. Methods We analysed signature...