A5010287296- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Breast Cancer Treatment Studies
- T-cell and B-cell Immunology
- melanin and skin pigmentation
- Genomics, phytochemicals, and oxidative stress
- Sex and Gender in Healthcare
- Mast cells and histamine
- Skin Protection and Aging
- Breast Lesions and Carcinomas
- Cellular transport and secretion
- Galectins and Cancer Biology
- Phagocytosis and Immune Regulation
- Breast Implant and Reconstruction
Sun Yat-sen University
2023-2025
Hebei Medical University
2024-2025
Fourth Hospital of Hebei Medical University
2024-2025
Sun Yat-sen University Cancer Center
2023-2025
Sex is known to be an important factor in the incidence, progression, and outcome of cancer. A better understanding underlying mechanisms could help improve cancer prevention treatment. Here, we demonstrated a crucial role antitumor immunity sex differences Consistent with observations human cancers, male mice showed accelerated tumor progression compared females, but these were not observed immunodeficient mice. Androgen signaling suppressed T-cell against males. Mechanistically,...
Abstract Cancer cells present sialylated glycoconjugates that modulate the activity of various immune within tumor microenvironment through trans interaction with immunosuppressive Siglec receptors. Identifying counter receptors for Siglecs can provide valuable targets cancer immunotherapy, but it presents significant challenges. Here, identification DSG2 (Desmoglein 2) as a dominant receptor Siglec‐9 in melanoma is reported, using workflow combines strength proximity labeling and advantage...
<div>Abstract<p>Sex is known to be an important factor in the incidence, progression, and outcome of cancer. A better understanding underlying mechanisms could help improve cancer prevention treatment. Here, we demonstrated a crucial role antitumor immunity sex differences Consistent with observations human cancers, male mice showed accelerated tumor progression compared females, but these were not observed immunodeficient mice. Androgen signaling suppressed T-cell against males....
<div>Abstract<p>Sex is known to be an important factor in the incidence, progression, and outcome of cancer. A better understanding underlying mechanisms could help improve cancer prevention treatment. Here, we demonstrated a crucial role antitumor immunity sex differences Consistent with observations human cancers, male mice showed accelerated tumor progression compared females, but these were not observed immunodeficient mice. Androgen signaling suppressed T-cell against males....
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<p>Supplementary Figure 1 and 2 Legends</p>
<p>Supplementary Figure 1 and 2 Legends</p>
<p>Supplementary Figure 2</p>
<p>Supplementary Figure 1</p>
<p>Supplementary Figure 2</p>