A5026513735- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- IL-33, ST2, and ILC Pathways
- vaccines and immunoinformatics approaches
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- T-cell and B-cell Immunology
- Plant biochemistry and biosynthesis
- Cancer Mechanisms and Therapy
- Sex and Gender in Healthcare
- Metamaterials and Metasurfaces Applications
- Genomics, phytochemicals, and oxidative stress
- melanin and skin pigmentation
- Phytochemical compounds biological activities
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Plasmonic and Surface Plasmon Research
- RNA modifications and cancer
- biodegradable polymer synthesis and properties
Chongqing University of Technology
2025
North China University of Science and Technology
2025
Weifang Maternity and Child Care Hospital
2025
Zaozhuang University
2023
Sun Yat-sen University
2021-2023
Sun Yat-sen University Cancer Center
2021-2023
Huazhong Agricultural University
2023
Tianjin Centers for Disease Control and Prevention
2014-2021
Tianjin Medical University
2014
University of Michigan
2010
Sex is known to be an important factor in the incidence, progression, and outcome of cancer. A better understanding underlying mechanisms could help improve cancer prevention treatment. Here, we demonstrated a crucial role antitumor immunity sex differences Consistent with observations human cancers, male mice showed accelerated tumor progression compared females, but these were not observed immunodeficient mice. Androgen signaling suppressed T-cell against males. Mechanistically,...
Supplementation with Selenium (Se) has been shown to lower blood cholesterol and increase tissue concentrations of the antioxidant glutathione (GSH); however, effects Se supplementation, in combination supplemental magnesium, on high fat-induced hyperlipidemia have not studied. This study was designed elucidate oral selenium magnesium co-supplementation antihyperlipidemic hepatoprotective, antioxidative activities, related gene expression a hyperlipidemic rat model.Forty male Sprague Dawley...
Metabolic syndrome (MetS) is increasingly viewed as a pressing concern for public health globally. The objective of this study was to compare the predictive ability 17 anthropometric indices risk MetS in Chinese residents, explore differences effect between different sexes, and identify optimal men women. This research utilized cross-sectional involving 5479 residents Shandong Province, China. According subjects' working curve (ROC), TyG-WHtR, TyG-WC, METS-VF, CVAI, LAP with area under (AUC)...
Abstract Hyperactive mevalonate (MVA) metabolic activity is often observed in cancer cells, and blockade of this pathway inhibits tumor cell lipid synthesis growth enhances immunogenicity. How MVA promotes antitumor immune responses, however, remains unclear. Here we show that inhibition the cells elicits type 1 classical dendritic (cDC1)–mediated recognition antigen cross-presentation for immunity. Mechanistically, disrupted prenylation small GTPase Rac1 induced actin filament exposure,...
Abstract Stage III non‐small cell lung cancer (NSCLC) encompasses a group of diseases with high heterogeneity. Such patients should actively receive comprehensive treatments. It is imperative for all stage NSCLC to consultation multiple disciplinary team, which allows the development proposal clinical diagnosis and treatment. In this consensus, divided into two types (operable inoperable) according different conditions. Resectable further subdivided conditions (with or without driver genes)....
Terahertz logic gates will have a wide range of applications in future 6G communications. In this study, we theoretically propose frequency-tunable all-optical terahertz gate composed silicon-metal composite metamaterial with liquid crystal (LC) layer. Simulation results demonstrate the presence electromagnetically induced transparency transmission spectrum device. Upon illumination, window can be altered owing to photoelectric effect Si segments. The designed device realize NOR Boolean...
Objective: To understand the epidemiological characteristics of imported COVID-19 cases in Tianjin, and provide references for risk assessment control cases. Methods: The information were obtained from National Notifiable Disease Report System China CDC. data reported Tianjin airport surveys by CDCs at all levels March 15, 2020 to August 31, 2021 collected analyzed using software Excel 2010, SPSS 25.0 R. Results: From 2021, a total 606 which 552 finally included analysis. male female ratio...
<div>AbstractPurpose:<p>Tumor genomic features have been of particular interest because their potential impact on the tumor immune microenvironment and response to immunotherapy. Due substantial heterogeneity, an integrative approach incorporating diverse molecular is needed characterize immunologic underlying primary resistance immunotherapy for establishment novel predictive biomarkers.</p>Experimental Design:<p>We developed a pan-cancer deep machine learning model...
<p>The supplementary figures illustrate Multifactorial deep learning model structures, Correlations of three types genomic alterations, Immune gene panel profile difference between GCs, Mismatch repair mutation frequency each GC, Gene Set Enrichment Analysis (GSEA) enriched pathways analysis for the stratification, GSEA results Van Allen's and TCGA melanoma cohorts, Immunotherapy response prediction survivals cohort, The mTMB, MSI burden, SCNA burden cohort in Deep combined Snyder's...
<p>Table S3 describes multivariate Cox regression analysis of variables in Van Allen's and Snyder's patients.</p>
<p>Table S3 describes multivariate Cox regression analysis of variables in Van Allen's and Snyder's patients.</p>
<p>The supplementary figures illustrate Multifactorial deep learning model structures, Correlations of three types genomic alterations, Immune gene panel profile difference between GCs, Mismatch repair mutation frequency each GC, Gene Set Enrichment Analysis (GSEA) enriched pathways analysis for the stratification, GSEA results Van Allen's and TCGA melanoma cohorts, Immunotherapy response prediction survivals cohort, The mTMB, MSI burden, SCNA burden cohort in Deep combined Snyder's...
<div>AbstractPurpose:<p>Tumor genomic features have been of particular interest because their potential impact on the tumor immune microenvironment and response to immunotherapy. Due substantial heterogeneity, an integrative approach incorporating diverse molecular is needed characterize immunologic underlying primary resistance immunotherapy for establishment novel predictive biomarkers.</p>Experimental Design:<p>We developed a pan-cancer deep machine learning model...
<p>Table S4 describes relationship between bench marker gene mutations and clinical benefit from ICI.</p>
<p>Table S4 describes relationship between bench marker gene mutations and clinical benefit from ICI.</p>
<div>Abstract<p>Sex is known to be an important factor in the incidence, progression, and outcome of cancer. A better understanding underlying mechanisms could help improve cancer prevention treatment. Here, we demonstrated a crucial role antitumor immunity sex differences Consistent with observations human cancers, male mice showed accelerated tumor progression compared females, but these were not observed immunodeficient mice. Androgen signaling suppressed T-cell against males....
<div>Abstract<p>Suppression of gluconeogenesis elevates glycolysis and is commonly observed in tumors derived from gluconeogenic tissues including liver kidney, yet the definitive regulatory mechanism remains elusive. Here, we screened an array transcription regulators identified enhancer zeste homolog 2 (EZH2) as a key factor that inhibits cancer cells. Specifically, EZH2 repressed expression rate-limiting enzyme fructose-1, 6-bisphosphatase 1 (FBP1) promoted tumor growth...
<div>Abstract<p>Sex is known to be an important factor in the incidence, progression, and outcome of cancer. A better understanding underlying mechanisms could help improve cancer prevention treatment. Here, we demonstrated a crucial role antitumor immunity sex differences Consistent with observations human cancers, male mice showed accelerated tumor progression compared females, but these were not observed immunodeficient mice. Androgen signaling suppressed T-cell against males....