A5058321132- Parkinson's Disease Mechanisms and Treatments
- Renal cell carcinoma treatment
- Neurological disorders and treatments
- Renal and Vascular Pathologies
- Bladder and Urothelial Cancer Treatments
- Organ Donation and Transplantation
- Renal and related cancers
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Glycogen Storage Diseases and Myoclonus
- EEG and Brain-Computer Interfaces
- Genital Health and Disease
- Ginkgo biloba and Cashew Applications
- Bariatric Surgery and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebral Palsy and Movement Disorders
- Neurological and metabolic disorders
- Balance, Gait, and Falls Prevention
- Sexuality, Behavior, and Technology
- Olfactory and Sensory Function Studies
PES University
2024
Parkinson's UK
2021
University of Toledo
1990-2019
Urology Associates
2018
Franciscan University of Steubenville
2018
University of Pittsburgh
2006-2017
University of Tennessee Health Science Center
2017
Michigan State University
2017
National Institute of Environmental Health Sciences
2017
Pennsylvania State University
2017
Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies severity, particularly high-intensity exercise.To examine the feasibility and safety of treadmill in patients with de novo who are not taking medication whether effect on motor symptoms warrants phase 3 trial.The Study Disease Exercise (SPARX) was 2, multicenter randomized clinical trial groups masked assessors. Individuals from outpatient community-based clinics were enrolled May 1,...
Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, clinical data.To determine whether sustained urate-elevating treatment the urate precursor inosine slows early PD progression.Randomized, double-blind, placebo-controlled, phase 3 trial of oral in PD. A total 587 individuals consented, 298 not yet requiring...
Background: As a common neurological disorder, the diagnosis of essential tremor (ET) is considered routine.Despite this, previous work suggests that misdiagnoses may be common.Among other things, these can lead to treatment errors.Objectives: To estimate how often disorders are misdiagnosed as ET and identify factors increase odds misdiagnosing precisely quantify extent which they do so.Design: Seventy-one consecutive patients underwent an evaluation at Neurological Institute New York,...
Excessive bleeding is a common and prognostically important complication of cardiac surgery. For related to coagulation factor deficiency, frozen plasma the most used therapy. Preliminary trials indicate that 4-factor prothrombin complex concentrate (PCC) may be suitable alternative. To compare efficacy safety PCC with in patients undergoing surgery coagulopathic bleeding. Unblinded randomized noninferiority controlled clinical trial at 12 hospitals Canada US involving adults (≥18 years) who...
<h3>Objective:</h3> To investigate olfaction in relation to incident Parkinson disease (PD) US white and black older adults. <h3>Methods:</h3> The study included 1,510 (mean age 75.6 years) 952 (75.4 participants of the Health, Aging, Body Composition study. We evaluated with Brief Smell Identification Test (BSIT) 1999–2000. retrospectively adjudicated PD cases identified through August 31, 2012, using multiple data sources. used multivariable Cox models estimate hazard ratios (HRs) 95%...
Organ shortage is the major limitation to kidney transplantation in developed world. Conversely, millions of patients developing world with end-stage renal disease die because they cannot afford replacement therapy-even when willing living donors exist. This juxtaposition between countries funds but no available kidneys and those prompts us propose an exchange program using each nation's unique assets. Our proposal leverages cost savings achieved through earlier over dialysis fund...
Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in Cardiovascular Health Study elderly community-based cohort adults.The baseline (µmol/l) incident PD over 14 years was assessed with locally weighted scatterplot smoothing (LOESS) regression from which categories low (<300 µmol/l), middle (300-500 high (>500 µmol/l) ranges were derived. Multivariate logistic models for each range. Linear quadratic terms tested...
Abstract Changes in cardiovascular physiology Parkinson's disease (PD) are common and may occur prior to diagnostic parkinsonian motor signs. We investigated associations of electrocardiographic (ECG) abnormalities, orthostasis, heart rate variability, carotid stenosis with the risk PD diagnosis Cardiovascular Health Study, a community‐based cohort older adults. ECG abnormality, orthostasis (symptomatic or asymptomatic), variability (24‐hour Holter monitoring), any (≥1%) by ultrasound were...
Background and Purpose: Objective ambulatory activity during daily living has not been characterized for people with Parkinson disease prior to initiation of dopaminergic medication. Our goal was characterize based on average step count examine determinants in nonexercising de novo disease. Methods: We analyzed baseline data from a randomized controlled trial, which excluded performing regular endurance exercise. Of 128 eligible participants (mean ± SD = 64.3 8.6 years), 113 had complete...
Abstract Tetrabenazine (TBZ), a presynaptic dopamine depletor and postsynaptic receptor blocker, is widely used for the treatment of hyperkinetic movement disorders in adults. However, reports its use children are limited. We review efficacy tolerability TBZ therapy 31 with refractory to other medications. was effective reducing severity resistant medicines. When compared adult patients, pediatric patients required higher doses. Side effects were similar population; however, had lower...
We describe a case of splenic injury caused by transsplenic percutaneous nephrostomy tract. The was completed without incident and the tube noted to traverse spleen on routine postoperative imaging. This rare complication managed deposition Gelfoam((R)) pledgets along tract placement ureteral stent. novel management technique has not been previously described in literature successful conservative treatment uncommon during nephrolithotomy.
With healthcare reform, cost and patient satisfaction will directly affect hospital reimbursement. We present data on same-day discharge (SDD) for patients who underwent robot-assisted laparoscopic radical prostatectomy (RALP).Patient were gathered in an IRB-approved database. In April 2015, the surgeon (S.J.) began SDD. The SDD protocol RALP includes multimodal anesthesia/analgesia extended recovery. Interim analysis revealed that government insurance (CMS) refused reimbursement As of time,...
Abstract Background: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes pupil diameter) is positively associated with sleepiness. We explored disease. Methods: (Epworth sleepiness scale sleep/fatigue domain of the nonmotor for disease) were assessed 31 participants (14 patients 17 controls). Effect sizes t tests compared disease control participants. Correlation coefficients calculated among arousal symptoms, unrest, Unified...
Physical therapy, including exercise, improves gait and quality of life in Parkinson's disease (PD). Many programs promoting physical activity have generated significant short-term gains, but adherence has been a problem. A recent evidence-based analysis clinical trials using therapy PD patients produced four key treatment recommendations: cognitive movement strategies, capacity, balance training, cueing. We attempted to incorporate all these features together through dance exercise program...
Parkinson disease (PD) is the second most common neurodegenerative disorder.Its diagnosis relies solely on a clinical examination and not straightforward because no diagnostic test exists.Large, population-based, prospective cohort studies designed to examine other outcomes that are more than PD might provide cost-efficient alternatives for studying disease.However, have implemented rigorous systematic screening PD.A majority of epidemiologic utilize population-based designs rely secondary...
The Tetrahedron-Tetrahedron truss (or TT for short) has exceptional stability, stiffness, and load-carrying capabilities. Because of this fact, the is well suited use as a variable geometry manipulator (VGTM) by appropriately choosing certain links whose lengths can be controlled. Since composed n-cells, its applications include retrieval equipment, bridges over around obstacles, which utilize collapsible programmable structures capable relatively large displacements. In paper an actuation...