A5110421138- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Pain Management and Opioid Use
- Nausea and vomiting management
- Blood Pressure and Hypertension Studies
- Airway Management and Intubation Techniques
- Hip and Femur Fractures
- Musculoskeletal pain and rehabilitation
- Pulmonary Hypertension Research and Treatments
- Adrenal Hormones and Disorders
- Acute Kidney Injury Research
- Climate Change and Health Impacts
- Surgical Simulation and Training
- Pain Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Spine and Intervertebral Disc Pathology
- Simulation-Based Education in Healthcare
- Salivary Gland Disorders and Functions
- Sarcoidosis and Beryllium Toxicity Research
- Intensive Care Unit Cognitive Disorders
- Neuroscience of respiration and sleep
- Tuberculosis Research and Epidemiology
- Diabetes and associated disorders
Cleveland Clinic
2013-2022
Outcomes Research Consortium
2016-2021
American Society of Anesthesiologists
2019-2020
University of Washington
2016-2020
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2020
Tel Aviv University
2020
Sağlık Bilimleri Üniversitesi
2018
Ministry of Health
2018
Edwards Lifesciences (Switzerland)
2018
Committee on Publication Ethics
2017
Intraoperative hypotension is associated with postoperative mortality. Early detection of by continuous hemodynamic monitoring might prompt timely therapy, thereby reducing intraoperative hypotension. We tested the hypothesis that noninvasive blood pressure reduces hypotension.Patients ≥45 years old American Society Anesthesiologists physical status III or IV having moderate-to-high-risk noncardiac surgery general anesthesia were included. All participating patients had using a finger cuff...
Abstract Background Various multimodal analgesic approaches have been proposed for spine surgery. The authors evaluated the effect of using a combination four nonopioid analgesics versus placebo on Quality Recovery, postoperative opioid consumption, and pain scores. Methods Adults having multilevel surgery who were at high risk double-blind randomized to placebos or single preoperative oral doses acetaminophen 1,000 mg gabapentin 600 mg, an infusion ketamine 5 µg/kg/min throughout surgery,...
Perioperative acute kidney injury is common. However, it unclear whether this merely represents a transient increase in creatinine or has prognostic value. Therefore, the long-term clinical importance of mild postoperative remains unclear. This study assessed adults who do and not experience after noncardiac surgery are at similar risk for renal injury.This retrospective cohort analysis having Cleveland Clinic had preoperative, postoperative, (1 to 2 yr surgery) plasma measurements. The...
Abstract Background Both saline and lactated Ringer’s solutions are commonly given to surgical patients. However, hyperchloremic acidosis consequent administration may provoke complications. The authors therefore tested the primary hypothesis that a composite of in-hospital mortality major postoperative complications is less common in patients solution than normal saline. Methods conducted an alternating cohort controlled trial which adults having colorectal orthopedic surgery were either or...
Whether intraoperative use of hydroxyethyl starch impairs kidney function remains unknown. The authors thus tested the primary hypothesis that Hextend promotes renal injury in surgical patients. Secondarily, evaluated dose-outcome relationship, in-hospital and 90-day mortality, whether relationship between colloid acute (AKI) depends on baseline risk for AKI.The data 44,176 adults without preexisting failure who had inpatient noncardiac surgery from 2005 to 2012. Patients given a combination...
Epidural analgesia is considered the standard of care but cannot be provided to all patients Liposomal bupivacaine has been approved for field blocks such as transversus abdominis plane (TAP) not clinically compared against other modalities. In this retrospective propensity matched cohort study we thus tested primary hypothesis that TAP infiltration are noninferior (not worse) continuous epidural and superior (better) intravenous opioid in recovering from major lower abdominal surgery. 318...
Abstract Background Brachial arterial catheters better estimate aortic pressure than radial but are used infrequently because complications in a major artery without collateral flow potentially serious. However, the extent to which brachial cannulation promotes remains unknown. The authors thus evaluated large cohort of cardiac surgical patients incidence related serious complications. Methods institutional Society Thoracic Surgeons Adult Cardiac Surgery Database and Perioperative Health...
BACKGROUND: Two-thirds of the US population is considered obese and about 8% morbidly obese. Obese patients may present a unique challenge to anesthesia clinicians in airway management. Videolaryngoscopes provide better visualization, which theoretically improves intubation success. However, previous work was limited. We therefore tested primary hypothesis that use McGrath video laryngoscope visualization vocal cords versus Macintosh direct laryngoscopy (Teleflex, Morrisville, NC) patients....
<h3>Importance</h3> Opioid-induced ventilatory depression and hypoxemia is common, severe, often unrecognized in postoperative patients. To the extent that nonopioid analgesics reduce opioid consumption, they may decrease hypoxemia. <h3>Objective</h3> test hypothesis duration of less patients given intravenous acetaminophen than those placebo. <h3>Design, Setting, Participants</h3> Randomized, placebo-controlled, double-blind trial conducted at 2 US academic hospitals among 570 who were...
In Brief BACKGROUND: Opioids can contribute to postoperative desaturation. Short-acting opioids, titrated need, may cause less desaturation than longer-acting opioids. We thus tested the primary hypothesis that long-acting patient-controlled intravenous opioids are associated with more hypoxemia (defined as an integrated area under a oxyhemoglobin saturation of 95%) short-acting METHODS: This analysis was substudy VISION, prospective cohort study focused on perioperative cardiovascular...
Frailty is associated with adverse postoperative outcomes, but it remains unclear which measure of frailty best. This study compared two approaches: the Modified Index, a deficit accumulation model (number accumulated deficits), and Hopkins Score, phenotype (consisting shrinking, weakness, exhaustion, slowness, low physical activity). The primary aim was to compare ability each score predict prolonged hospitalization. Secondarily, 30-day readmission and/or complications compared.This...
Abstract Introduction To date, there have been no acceptable and accurate diagnostic criteria or standards of care for the management sacroiliac joint (SIJ) pain. Several studies yielded different contributions clinical presentation, history, physical examination in diagnosis SIJ Our goal this study was to assess sensitivity specificity tests their predictive value accurately diagnosing Methodology Upon enrolling 200 eligible patients with pain as primary diagnosis, they were re‐evaluated...
Hypotension is associated with acute kidney injury, but vasopressors used to treat hypotension may also compromise renal function. We therefore tested the hypothesis that vasopressor infusion during complex spine surgery not impaired
Prompt treatment of severe blood pressure instability requires both cognitive and technical skill. The ability to anticipate respond episodes hemodynamic should improve with training. authors tested the hypothesis that duration hypotension during anesthesia administered by residents correlates concurrent adjusted overall performance evaluations Clinical Competence Committee subsequent in-training exam scores.The obtained data on 70 first- second-year at Cleveland Clinic. Analysis was...