A5077056483- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- NF-κB Signaling Pathways
- interferon and immune responses
- Inflammasome and immune disorders
- Nitric Oxide and Endothelin Effects
- Cancer Immunotherapy and Biomarkers
- High Altitude and Hypoxia
- Immune Cell Function and Interaction
- Statistical Methods in Clinical Trials
- Hepatocellular Carcinoma Treatment and Prognosis
- Spinal Dysraphism and Malformations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Esophageal and GI Pathology
- Plasma and Flow Control in Aerodynamics
- TGF-β signaling in diseases
- Adhesion, Friction, and Surface Interactions
- Tribology and Lubrication Engineering
- Plant Surface Properties and Treatments
Sichuan University
2011-2025
Second Affiliated Hospital of Zhejiang University
2024-2025
State Key Laboratory of Biotherapy
2015-2024
China Jiliang University
2022-2024
State Key Laboratory of Oral Diseases
2020-2021
Purdue University West Lafayette
2015
The extracellular matrix (ECM) is a significant constituent of tumors, fulfilling various essential functions such as providing mechanical support, influencing the microenvironment, and serving reservoir for signaling molecules. abundance degree cross-linking ECM components are critical determinants tissue stiffness. In process tumorigenesis, interaction between immune cells within tumor microenvironment (TME) frequently leads to stiffness, thereby disrupting normal mechanotransduction...
The NLRP3 inflammasome, a pivotal component of innate immunity, has been implicated in various inflammatory disorders. ubiquitin-editing enzyme A20 is well known to regulate inflammation and maintain homeostasis. However, the precise molecular mechanisms by which modulates inflammasome remain poorly understood. Here, our study revealed that macrophages deficient exhibit increased protein abundance elevated mRNA level NIMA-related kinase 7 (NEK7). Importantly, directly binds with NEK7,...
Diabetic retinopathy (DR) is a major cause of blindness globally. Neutrophils and neutrophil extracellular traps (NETs) are believed to play role in the development DR. However, specific contribution NETs hyperglycemia-induced vascular endothelial cell dysfunction remains unclear. In this study, we cocultured high glucose-activated neutrophils (HGNs) with human umbilical vein cells (HUVECs) investigate glucose-induced HUVEC dysfunction. Our findings indicate that glucose levels promote...
MicroRNAs (miRNAs) are an abundant class of endogenous small non-coding RNAs 20-25 nucleotides in length that function as negative gene regulators. MiRNAs play roles most biological processes, well diverse human diseases including cancer. Recently, many studies investigated the association between SNPs miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs229283, miR-499 rs3746444 and colorectal cancer (CRC), which results have been inconclusive.PubMed, EMBASE, CNKI databases were searched...
Myeloid-derived suppressor cells (MDSCs) are one of the major components tumor microenvironment. Evidence has shown differences in functions and fates MDSCs tissue periphery. However, exact mechanism that regulates MDSC function not been completely clarified. In this study, we performed RNA sequencing derived from spleen tumor. Based on results our RNA-seq analysis, mitogen-activated protein kinases (MAPK) were significantly increased polymorphonuclear (PMN-MDSCs) monocytic (M-MDSCs)....
Abstract Myeloid-derived suppressor cells (MDSCs) are known to play important roles in the development of immunosuppressive tumor microenvironment. A20 is a zinc-finger protein which could negatively regulate apoptosis several cell types. However, role microenvironment remains largely unknown. In this study, we found that was over-expressed MDSCs. The treatment tumor-bearing mice with small interfering RNA targeting (si-A20) inhibited growth tumors. infiltration MDSCs dramatically reduced...
Abstract Purpose A pathologic complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) is seen in up 40% of the patients with esophageal squamous cell carcinoma (ESCC). No nomogram has been constructed for prediction pCR whose primary chemotherapy was a taxane‐based regimen. The aim identify characteristics associated through analyzing multiple pre‐ and post‐nCRT variables develop these by integrating clinicopathological hematological biomarkers. Materials Methods We analyzed 293 ESCC...
The characteristics of the material transported by two-vane pump can cause impeller to wear out, leading a deterioration in hydraulic efficiency. Appropriately, research goal this paper is consolidate anti-wear performance conveying solid-liquid two-phase flow. Based on bionic principle and structure blood clams, circular non-smooth adapted from clams arranged wear-prone area. Through numerical simulation, we compare main indexes pump: head, pressure distribution, vortex pressures, average...
Below a threshold size, small pore nucleated in fluid sheet will contract to minimize the surface energy. Such behavior plays key role nature and technology, from nanopores biological membranes sensors for rapid DNA RNA sequencing. Here we show that viscous sheets collapse following universal scaling law radius. High-fidelity numerical simulations reveal is largely independent of initial conditions, including shape, thickness original nanopore. Results further yields constant speed as...
The aim of the study is to discuss risk factor right heart failure (RHF) especially association iron deficiency with RHF in Tibetan children who live high altitude area. In this retrospective study, we collected data from January 2011 December 2018 our hospital. patients included had following data: age, gender, ferritin, echocardiography, hemoglobin, C-reaction protein, and residence. According whether was diagnosed, were divided into group non-RHF group. Totally 133 59 74 single analysis,...