A5000235030- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Autoimmune and Inflammatory Disorders
- Pharmaceutical industry and healthcare
- Pharmaceutical Practices and Patient Outcomes
- Childhood Cancer Survivors' Quality of Life
- Child Abuse and Trauma
- Neurotransmitter Receptor Influence on Behavior
- Systemic Sclerosis and Related Diseases
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Neurofibromatosis and Schwannoma Cases
- Poisoning and overdose treatments
- Pain Management and Opioid Use
- Opioid Use Disorder Treatment
- Statistical Methods in Clinical Trials
- Glutathione Transferases and Polymorphisms
- Tuberous Sclerosis Complex Research
- Global Public Health Policies and Epidemiology
- Pharmaceutical Economics and Policy
- Medical Research and Practices
- Chronic Myeloid Leukemia Treatments
Primary Children's Hospital
2012-2018
Intermountain Healthcare
2018
University of Utah
2013-2015
Cincinnati Children's Hospital Medical Center
2007-2014
University of Cincinnati
2007-2013
University of Cincinnati Medical Center
2009-2013
Purdue University West Lafayette
2003
The genotype responsible for more than 60-fold interindividual differences in human hepatic CYP1A2 constitutive expression is not understood. Resequencing the CYP1A1_CYP1A2 locus (39.6 kb) five major geographically isolated subgroups recently led to identification of 85 single nucleotide polymorphisms (SNPs), 57 which were double-hit SNPs. Here, we attempted correlate with a metabolic phenotype. We chose 16 SNPs (all having minor allele frequency ≥0.05 Caucasians) 32 DNA samples (26...
Antipsychotic polypharmacy-the use of more than one antipsychotic concomitantly-has increased in children and adolescents may be associated with adverse effects, nonadherence, greater costs. Thus, we sought to examine the demographic clinical characteristics psychiatrically hospitalized who were prescribed polypharmacy identify predictors this prescribing pattern.Retrospective medical record review.The inpatient psychiatric unit a large, acute care, urban children's hospital.One thousand...
To prospectively determine factors associated with codeine's adverse drug reactions (ADRs) at home in a large homogenous population of children undergoing outpatient tonsillectomy.Prospective, genotype blinded, observational study single group and repeated ADR measures documented by parents home.A total 249 6 to 15 years age scheduled for tonsillectomy were enrolled. The primary outcome was number daily codeine-related ADRs. We examined the type race days further modeled potentially risk...
The narrow therapeutic index and large interpatient variability in sirolimus pharmacokinetics (PK) make drug monitoring necessary. Factors responsible for PK are not well understood, published studies do include pediatric patients with neurofibromatosis type 1 (NF1). objectives of this study were to estimate clearance a cohort children NF1 using data collected concentration-guided trial, evaluate the effect treatment duration on dose requirements, association patient-specific factors,...
The study aims were to characterize risperidone and (±)-9-hydroxyrisperidone pharmacokinetic (PK) variability in children adolescents evaluate covariate effects on PK parameters.Steady-state samples drawn at predose, 1, 2, 4, 7 hours postdose; cytochrome P450 2D6 (CYP2D6) genotypes available for 28 subjects. A nonlinear mixed-effects model (NONMEM) modeled the PKs of (±)-9-hydroxyrisperidone; covariates included age, weight, sex, CYP2D6 phenotype. 497 observations [risperidone (n = 163), (+)...
Objective: The aim of this study was to examine the association between CYP2D6 and CYP2C19 genotype-predicted combined phenotypes short-term measures psychotropic efficacy toxicity. Methods: A rater-blinded, retrospective genotype design examined a cohort hospitalized pediatric psychiatric patients genotyped for as part clinical care. These genotypes were used predict phenotype. primary outcome measure behavior intervention score (BIS), function number recorded timeouts/seclusions,...
In the United States, medication nonadherence accounts for 10% of all hospital admissions and 33–69% medication-related admissions, resulting in direct costs $100–$289 billion annually.1,–6 Inadequate information about a lack understanding are barriers to adherence many patients.7,–11 Pharmacist-provided education that targets adherence-related factors is necessary help reduce these hospitalizations. This critical area which pharmacists well positioned have significant impact. There growing...
In this study, human embryonic kidney (HEK)-293 cells stably expressing human, <i>Drosophila</i>, or a chimeric serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, dSERT, and H<sup>1–281</sup>D<sup>282–476</sup>H<sup>477–638</sup>, respectively) were used to explore the ability of two libraries structurally distinct psychostimulants inhibit 5-HT uptake. One library consisted 3-phenyltropane analogs, whereas second several substituted amphetamines. hSERT exhibited lower...
The Medication Education Groups Taskforce, under the purview of Legislative Committee initiated and sent a survey during fall 2012. intent was to use information from share resources related group medication education that we are all using in our respective practice sites discuss terminology billing mechanisms. only those CPNP members who had replied listserv email regarding interest provision groups.The 72 individuals with 47 responding at least 1 question, for an overall response rate 65%....