A5066631249- Cytokine Signaling Pathways and Interactions
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Lipid metabolism and disorders
- Acute Myeloid Leukemia Research
- Pancreatic function and diabetes
- RNA modifications and cancer
- CAR-T cell therapy research
- Gene Regulatory Network Analysis
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Immune cells in cancer
Heidelberg University
2022-2024
German Cancer Research Center
2022-2024
Heidelberg Institute for Stem Cell Technology and Experimental Medicine
2022-2024
MRC Centre for Regenerative Medicine
2021
University of Edinburgh
2020-2021
Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem progenitor cells (HSPCs) sense non-systemic influenza A virus (IAV) infection via inflammatory cytokines. Irrespective antiviral treatment or vaccination, at certain threshold IAV titer in lung, CD41-positive (HSCs) enter cell cycle while endothelial protein C...
Residing at the top of hematopoietic hierarchy, long-term stem cells (HSCs) are capable self-renewal and sustained blood cell regeneration. Over past decades, single-cell clonal analyses have revealed substantial functional molecular heterogeneity within this compartment, challenging notion that is inherently tied to balanced, multi-lineage production. However, a cohesive model explains relationships among these diverse HSC states remains elusive. Here, we combined transplantations over...
Infant MLL-AF4-driven acute lymphoblastic leukemia (ALL) is a devastating disease with dismal prognosis. A lack of understanding the unique biology this disease, particularly its prenatal origin, has hindered improvement survival. We perform multiple RNA sequencing experiments on fetal, neonatal, and adult hematopoietic stem progenitor cells from human mouse. This allows definition conserved fetal transcriptional signature characterized by prominent proliferative oncogenic nature that...
Background: Polycythemia Vera (PV) is initiated and maintained by mutant HSCs clones that acquired the JAK2V617F mutation drive erythrocytosis in patients. So far, only Pegylated Interferon alpha (Peg-IFN-α) demonstrates a durable molecular response clinic; however, it often associated with side effects leading to therapy discontinuation. Previous works suggest Peg-IFN-α may deplete inducing their entry into cell cycle, DNA damage subsequent exhaustion. This indicates quiescence of be...