A5064877189- Fatty Acid Research and Health
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Diet, Metabolism, and Disease
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Electron Spin Resonance Studies
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Regulation of Appetite and Obesity
- Cardiovascular Effects of Exercise
- RNA Research and Splicing
- Religion, Theology, and Education
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Religious Education and Schools
- Cardiomyopathy and Myosin Studies
- Cardiovascular Health and Disease Prevention
- Tissue Engineering and Regenerative Medicine
Postgraduate School of Molecular Medicine
2008-2024
Centrum Medyczne Kształcenia Podyplomowego
2010-2023
TU Dortmund University
2014
University of Maryland, Baltimore
2007-2009
Case Western Reserve University
2006-2009
University of Colorado Denver
2009
University of Colorado Boulder
2009
University of Maryland Medical Center
2007
Institute of Molecular Biology and Biophysics
2006-2007
Clinical studies suggest that intake of omega-3 polyunsaturated fatty acids (omega-3 PUFA) may lower the incidence heart failure. Dietary supplementation with PUFA exerts metabolic and anti-inflammatory effects could prevent left ventricle (LV) pathology; however, it is unclear whether these occur at clinically relevant doses there are differences between from fish [eicosapentaenoic acid (EPA) docosahexaenoic (DHA)] vegetable sources [alpha-linolenic (ALA)].We assessed development LV...
Objective Epidemiological studies suggest that consumption of ω-3 polyunsaturated fatty acids (ω-3 PUFA) decreases the risk heart failure. We assessed effects dietary supplementation with PUFA from fish oil on response left ventricle (LV) to arterial pressure overload.
Cardiac hypertrophy is accompanied by molecular remodeling that affects different cellular pathways, including fatty acid (FA) utilization. In the present study, we show cardiac lipid metabolism differentially regulated in response to physiological (endurance training) and pathological [abdominal aortic banding (AAB)] hypertrophic stimuli. Physiological was an increased expression of lipogenic genes activation sterol regulatory element-binding protein-1c Akt signaling. Additionally, FA...
Chronic hypertension leads to cardiac hypertrophy, heart failure, and premature death. Little is known about the impact of dietary macronutrient composition on hypertension-induced hypertrophy mortality. We investigated effects consuming either a high complex carbohydrate diet, simple sugar or fat diet mortality in hypertensive Dahl salt-sensitive (DSS) rats.Rats were assigned four diets: (CC; 70% starch, 10% fat, 20% protein by energy), (FAT; carbohydrates, 60% protein), fructose (FRU;...
Sugar consumption affects insulin release and, in hypertension, may stimulate cardiac signaling mechanisms that accelerate left ventricular hypertrophy and the development of heart failure. We investigated effects high-fructose or sucrose diets on function mortality hypertensive Dahl salt-sensitive rats.Rats were fed chows either high starch (70% starch, 10% fat by energy), (20% carbohydrates, 60% fat), fructose (61% fructose, 9% sucrose, fat). Hypertension was induced adding 6% salt to chow...
Ventricular arrhythmias are an important cause of mortality in the acute myocardial infarction (MI). To elucidate effect ivabradine, pure heart rate (HR) reducing drug, on ventricular within 24 h after non-reperfused MI rat. ECG was recorded for untreated and ivabradine treated rats episodes tachycardia/fibrillation (VT/VF) were identified. Forty-five minutes twenty-four hours epicardial monophasic action potentials (MAPs) recorded, cardiomyocyte Ca2+ handling assessed expression function...
Supplementation with eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) from fish oil may prevent development of heart failure through alterations in cardiac phospholipids that favorably impact inflammation energy metabolism. A high-fat diet block these effects chronically stressed myocardium. Pathological left ventricle (LV) hypertrophy was generated by subjecting rats to pressure overload constriction the abdominal aorta. Animals were fed: (1) standard (10% fat), (2) EPA+DHA (2.3%...
Disturbances in cardiac lipid metabolism are associated with the development of hypertrophy and heart failure. Spontaneously hypertensive rats (SHRs), a genetic model primary hypertension pathological left ventricular (LV) hypertrophy, have high levels diacylglycerols cardiomyocytes early development. However, exact effect lipids pathways that involved their on dysfunction SHRs is unknown. Therefore, we used Wistar Kyoto (WKY) at 6 18 weeks age to analyze impact perturbations processes...
Objectives: A hypothesis was tested that a reaction product between superoxide (O2−) and nitric oxide (NO) mediates post-ischemic coronary endothelial dysfunction ischemic preconditioning (IPC) protects the endothelium by preventing cardiac O2− and/or NO formation, opening of mitochondrial ATP-dependent potassium channel (mKATP) plays role in mechanism IPC. Methods: Langendorff-perfused guinea-pig hearts were subjected either to 30 min global ischemia/30 reperfusion (IR) or preconditioned...
The superoxide-forming NADPH oxidase homologues, Nox1, Nox2, and Nox5, seem to mediate the pro-atherosclerotic vascular phenotype. hydrogen peroxide-forming Nox4 afforded protection, likely via NF-E2-related factor-2 (Nrf2) activation and/or Nox2 downregulation in transgenic mice. We hypothesized that oxidative stress intact vasculature involves, aside from upregulation of Noxs, Nox4/Nrf2 pathway. Guinea-pigs rats were studied either winter or summer, streptozotocin diabetic winter. Plasma...
Diet-induced hypercholesterolaemia exacerbates post-myocardial infarction (MI) ventricular remodelling and heart failure, but the mechanism of this phenomenon remains unknown. This study examined whether worsening post-MI induced by dietary was related to upregulation angiotensin II type 1 (AT1) receptor in rat heart.MI surgically rats fed normal or high cholesterol diet. Both groups were then assigned control, atorvastatin, losartan atorvastatin+losartan-treated subgroups followed for 8...
We tested the hypothesis that low-density lipoprotein-cholesterol induces angiotensin II type 1 receptor upregulation that, in turn, accounts for enhanced oxidative stress, and subsequent endothelial dysfunction patients with coronary artery disease.Brachial flow-mediated vasodilation, serum 8-iso-prostaglandin F2alpha (8-isoprostane), density on platelets were measured 19 disease, at entry after 12 weeks of simvastatin therapy, 40 mg/day.At there was a significant linear correlation...
Ventricular arrhythmias are an important cause of mortality in the acute myocardial infarction (MI). To elucidate effect omega-3 polyunsaturated fatty acids (PUFAs) on ventricular nonreperfused MI, rats were fed with normal or eicosapentaenoic acid (EPA) docosahexaenoic (DHA)-enriched diet for 3 weeks. Subsequently subjected to either MI induction sham operation. ECG was recorded 6 h after operation and episodes tachycardia/fibrillation (VT/VF) identified. Six hours epicardial monophasic...
Abstract The incidence of life-threatening ventricular arrhythmias, the most common cause sudden cardiac death (SCD), depends largely on arrhythmic substrate that develops in myocardium during aging process. There is a large deficit comparative studies development this both sexes, with particular paucity females. To identify substrates arrhythmia, fibrosis, cardiomyocyte hypertrophy, mitochondrial density, oxidative stress, antioxidant defense and intracellular Ca 2+ signaling isolated...
Stearoyl-CoA desaturase (SCD) is a lipogenic enzyme that catalyzes formation of the first double bond in carbon chain saturated fatty acids. Four isoforms SCD have been identified mice, most poorly characterized which SCD4, cardiac-specific. In present study, we investigated role SCD4 systemic and cardiac metabolism. We used wildtype (WT) global knockout mice were fed standard laboratory chow or high-fat diet (HFD). deficiency reduced body adiposity decreased hyperinsulinemia...
Hypertrophic cardiomyopathy is the most common cardiovascular disease, which characterized by structural and functional myocardial abnormalities. It caused predominantly autosomal dominant mutations, mainly in genes encoding cardiac sarcomeric proteins, resulting diverse phenotypical patterns a heterogenic clinical course. Unconventional myosin VI (MVI) one of proteins important for heart function, as it was shown that point mutation within MYO6 associated with left ventricular hypertrophy....