A5082920242- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cancer Genomics and Diagnostics
- Mechanical Circulatory Support Devices
- Bariatric Surgery and Outcomes
- Transplantation: Methods and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Heart Failure Treatment and Management
- Molecular Biology Techniques and Applications
- Complement system in diseases
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- RNA and protein synthesis mechanisms
- Potassium and Related Disorders
- Congenital heart defects research
- Adrenal and Paraganglionic Tumors
- Alzheimer's disease research and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
Medical College of Wisconsin
2022-2024
Ann Arbor Center for Independent Living
2024
UPMC Hillman Cancer Center
2024
Gundersen Health System
2024
Stony Brook University Hospital
2023
Indiana University
2023
University School
2023
Indiana University School of Medicine
2023
Indiana University Health
2023
Digestive Health Research Institute
2023
The Cancer Genomics Hub (CGHub) is the online repository of sequencing programs National Institute (NCI), including Atlas (TCGA), Cell Line Encyclopedia (CCLE) and Therapeutically Applicable Research to Generate Effective Treatments (TARGET) projects, with data from 25 different types cancer. CGHub currently contains >1.4 PB data, has grown at an average rate 50 TB a month serves >100 per week. architecture designed support bulk searching downloading through Web-accessible application...
Controversy exists as to whether current pretreatment prostate-specific antigen (PSA) dynamics enhance outcome prediction in patients undergoing treatment for prostate cancer. We assessed PSA velocity (PSAV) or doubling time (PSADT) predicted men radical prostatectomy and any definition enhanced accuracy of an model.The cohort included 2,938 with two more values before prostatectomy. Biochemical recurrence (BCR) occurred 384 patients, metastases 63 patients. Median follow-up without BCR was...
Abstract Germline variants in tumor suppressor genes (TSGs) can result RNA mis-splicing and predisposition to cancer. However, identification of that impact splicing remains a challenge, contributing substantial proportion patients with suspected hereditary cancer syndromes remaining without molecular diagnosis. To address this, we used capture RNA-sequencing (RNA-seq) generate profile 18 TSGs ( APC , ATM BRCA1 BRCA2 BRIP1 CDH1 CHEK2 MLH1 MSH2 MSH6 MUTYH NF1 PALB2 PMS2 PTEN RAD51C RAD51D...
The explanation why water exchange colonoscopy produces a significant reduction of pain during is unknown. A recent editorial recommended use magnetic endoscope imaging (MEI) to elucidate the explanation.In unselected patients show that MEI documents less frequent loop formation when used.Observational, performance improvement.Veterans Affairs outpatient endoscopy.Routine cases.Colonoscopy using air or method was performed as previously described. equipment (ScopeGuide, Olympus) with...
Quality of life is an important consideration in the treatment early prostate cancer. Laboratory and clinical data suggest that higher radiation doses delivered to bulb penis proximal penile structures correlates with rates post-radiation impotence. The goal this investigation was determine if intensity-modulated therapy (IMRT) spares dose while maintaining coverage prostate. 10 consecutive patients clinically organ confined cancer were planned 3D conformal (3D-CRT) or IMRT give a 74 Gy...
Abstract Prostate‐specific antigen (PSA) dynamics have been proposed to predict outcome in men with prostate cancer. We assessed the value of PSA velocity (PSAV) and doubling time (PSADT) for predicting cancer‐specific mortality (PCSM) clinically localized cancer undergoing conservative management or early hormonal therapy. From 1990 1996, 2,333 patients were identified, whom 594 had two more values before diagnosis. examined 12 definitions PSADT 10 PSAV. Because each definition required...
In 2003, we presented an open source, web-based prostate cancer database developed to integrate clinical practice and research workflows at the IEEE Symposium on Computer- Based Medical Systems [1]. Caisis was designed around structured chronological patient histories which could be displayed clinicians processed by computer algorithms. We extended system handle 9 diseases. It has been adopted 15 sites in 4 countries with over 400 users is currently used manage data for 165,000 patients....
Next-Generation Sequencing (NGS) allows rapid analysis of multiple genes for the detection clinically actionable variants. This study reports analytical validation a targeted pan cancer NGS panel CANSeq TM Kids molecular profiling childhood malignancies. Analytical included DNA and RNA extracted from de-identified clinical specimens including formalin fixed paraffin embedded (FFPE) tissue, bone marrow whole blood as well commercially available reference materials. The component evaluates 130...
PTEN mutations are associated with breast, colon, endometrial, kidney, and thyroid cancers. Most promoter alterations, however, characterized as variants of unknown significance, their contribution to cancer risk is unclear.Personal family histories 88,333 patients undergoing analysis part multigene panel testing (MGPT) were retrospectively reviewed. Cases (n = 59,784) individuals personal history PTEN-related cancer. Controls 28,549) had no Individuals categorized positive for one or more...
Paroxysmal nocturnal hemoglobinuria is a rare blood disorder characterized by life-threatening hemolysis and thrombosis. Complement C5 inhibitor therapy improves symptoms life prognosis; however, it can result in insufficient control, with residual intravascular extravascular some patients. Pegcetacoplan, the first complement C3 approved for patients paroxysmal hemoglobinuria, targets both hemolysis. This analysis evaluated population pharmacokinetic/pharmacodynamic profiles of...
Abstract While there is no shortage of approved targeted therapeutics to address driver mutations in NSCLC, many patients are not tested for these alterations due gaps biomarker testing access. Challenges NSCLC molecular include the need assessment multiple variants both DNA and RNA, samples often small specimens, cost, clinical rapid turn-around time when deteriorating require timely treatment initiation. ASPYRE-Lung detects a panel 114 actionable genomic across 11 genes, covering NCCN...
Many patients with non-small cell lung cancer (NSCLC) lack access to highly effective approved targeted therapeutics due multiple gaps in biomarker testing. Challenges comprehensive molecular testing include complexities associated the need assess presence of variants, costs running sequential assays per sample, high assay quality control (QC) failure rates, clinical for rapid turn-around time (TAT) initiate therapy, and insufficient tissue samples. The ASPYRE-Lung NSCLC addresses...
Abstract Background VY‐TAU01 is a recombinant humanized IgG4 monoclonal antibody (mAb) directed against pathological tau for the treatment of patients with mild dementia or cognitive impairment due to Alzheimer’s disease (AD). Both and its parental mouse IgG1 mAb Ab‐01 target an epitope in C‐terminus tau, bind high affinity selectivity over wild‐type block paired helical filament seed‐induced aggregates vitro, selectively stain tangles AD P301S (C57/B6J‐Tg[Thy1‐MAPT*P301S]2541Godt) brain....
You have accessJournal of UrologyModerated Poster 12, Sunda~May20,2007 1:00 - 3:00 pm1 Apr 2007383: Which Definition PSA Doubling Time or Velocity best Predicts Outcome after Radical Prostatectomy? Matthew F. O'Brien, Paul A. Feam, Brandon Smith, Jason Stasi, Angel M. Serio, Andrew J. Vickers, James Eastham, and Hans G. Lilja O'BrienMatthew O'Brien More articles by this author , FeamPaul Feam SmithBrandon Smith StasiJason Stasi SerioAngel Serio VickersAndrew Vickers EasthamJames Eastham...
Purpose: Water exchange colonoscopy produces a significant reduction of pain (scheduled unsedated patients), lower patient-controlled medication requirement sedated patients) and higher proportion patients completing (on-demand patients). The method entails omission air insufflation removal residual to minimize lumen distension flexure angulation. Less need for abdominal pressure position change indirectly suggest less looping may account alleviation. No objective evidence currently exists...
Topic: 12. Bone marrow failure syndromes incl. PNH - Clinical Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder associated with bone and thrombosis. Pegcetacoplan, targeted complement protein C3 therapy, approved for the treatment of in European Union, United Kingdom, States. Aims: Exposure-response (E-R) relationships were investigated using hemoglobin (Hb) lactate dehydrogenase (LDH) as clinical efficacy endpoints to inform proposed dose....
You have accessJournal of Urology1 Apr 2008PRE-DIAGNOSTIC PROSTATE SPECIFIC ANTIGEN DYNAMICS DO NOT IMPROVE AN OUTCOME PREDICTION MODEL CONTAINING LEVELS ALONE IN PATIENTS WITH CLINICALLY LOCALIZED CANCER TREATED CONSERVATIVELY OR EARLY HORMONAL THERAPY M Frank O'Brien, Angel Serio, Paul Fearn, Brandon Smith, Jason Stasi, Andrew J Vickers, Peter T Scardino, Tim Oliver, Henrik Moller, Gabrielle Fisher, Jack Cusick, James A Eastham, and Hans Lilja O'BrienM O'Brien More articles by this author...