A5018507546- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- T-cell and B-cell Immunology
- Prostate Cancer Treatment and Research
- Axon Guidance and Neuronal Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Prostate Cancer Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Breast Implant and Reconstruction
- Scoliosis diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- Osteoarthritis Treatment and Mechanisms
- IL-33, ST2, and ILC Pathways
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- Respiratory and Cough-Related Research
- Hearing, Cochlea, Tinnitus, Genetics
- Inhalation and Respiratory Drug Delivery
- Mast cells and histamine
- Complement system in diseases
- Angiogenesis and VEGF in Cancer
- Medicinal plant effects and applications
- Cytokine Signaling Pathways and Interactions
McGill University Health Centre
2013-2020
McGill University
2005-2017
University of Bern
2014-2015
AO Foundation
2014-2015
Joachim Herz Stiftung
2014-2015
Christie (Canada)
2005-2015
Nuffield Orthopaedic Centre
2015
Royal Orthopaedic Hospital
2015
Centre Hospitalier Universitaire Sainte-Justine
2009-2013
Université de Montréal
2012
Abstract An overall decline in the availability of osteogenic precursor cells and growth factors bone marrow microenvironment have been associated with impaired formation osteopenia humans. The objective current study was to determine if transplantation mesenchymal stromal (MSC) from a healthy, young donor mouse into an osteopenic recipient could enhance osseointegration femoral implant. MSC harvested normal adult mice differentiated forming osteoblasts when cultured on implant grade...
Endothelin-1, a vasoconstrictor peptide, influences cartilage metabolism mainly via endothelin receptor type A (ETA). Along with the inflammatory nonapeptide vasodilator bradykinin (BK), which acts B1 (BKB1) in chronic conditions, these vasoactive factors potentiate joint pain and inflammation. We describe preclinical study of efficacy treatment surgically induced osteoarthritis ETA and/or BKB1 specific peptide antagonists. hypothesize that antagonism both receptors will diminish progress...
Summary Background Intravenous immunoglobulin (IVIG) has potent anti‐inflammatory and immune‐modulating properties. IVIG been utilized as a steroid‐sparing agent in severe asthma, but the results of clinical trials have conflicting. Objective To determine whether is able to attenuate bronchial reactivity, pulmonary inflammation T cell function using murine model allergic airways disease. Methods BALB/c or C57BL/6 mice were sensitized ovalbumin (OVA) phosphate‐buffered saline control local...
The regulatory properties of B cells have been studied in autoimmune diseases; however, their role allergic diseases is poorly understood. We demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, plays a crucial cell function. Mice deficient Sema4C exhibited increased airway inflammation after allergen exposure, with massive eosinophilic lung infiltrates and Th2 cytokines. This phenotype was reproduced by mixed bone marrow chimeric mice only cells, indicating lymphocytes were...
Semaphorins are important molecules in embryonic development and multiple semaphorins have been identified as having key roles immune regulation. To date, there is little known about Semaphorin 4C (Sema4C) biology. We report for the first time that Sema4C inducible human murine B-cells may be normal B-cell development. Human tonsillar were studied following activation via anti-CD40 antibodies presence or absence of representative Th1, Th2, regulatory cytokines. Murine from WT Sema4C-/- mice...
Abstract IVIg is widely used as an immunomodulatory therapy. We have recently demonstrated that protects against airway hyperresponsiveness (AHR) and inflammation in mouse models of allergic airways disease (AAD), associated with induction Foxp3+ regulatory T cells (Treg). Using mice carrying a DTR/EGFP transgene under the control Foxp3 promoter (DEREG mice), we demonstrate this study generates de novo population peripheral Treg (pTreg) absence endogenous Treg. IVIg-generated pTreg were...
We used a microarray approach to evaluate gene expression profiles in human AIS osteoblasts, and identify genes that are differentially expressed following estrogen exposure non-AIS osteoblasts. found more than one is likely responsible for AIS. Furthermore, some of these estrogen-regulated, suggesting possible role estrogens the etiology scoliosis.
Abstract We have shown that induced regulatory T cells (iTreg) are necessary and sufficient to rescue antigen-challenged mice in a murine model of allergic airways disease (AAD). Intravenous immunoglobulin (IVIg) treatment wild-type sensitized challenged antigen induces Treg dendritic-cell (DC) dependent mechanism. In the present study, DEREG (which co-express diphtheria toxin (DT) receptor with Foxp3, allowing for selective transient depletion Treg) were treated IVIg after all endogenous...
Background IVIg is a polyclonal IgG preparation with potent immune-modulating properties. We demonstrated that protects against airway hyperreactivity (AHR) and inflammation in mouse models of allergic disease, accompanied by peripheral induction Foxp3 regulatory T-cells (iTreg). The requirement IVIginduced iTreg their antigen-specificity attenuation AHR remains unknown.