Human organic anion-transporting polypeptide B (OATP-B; OATP2B1) is expressed in the human intestinal epithelial cells, and suggested to be involved absorption of anionic drugs vivo. Although citrus juices have been shown inhibit function OATP-A (OATP1A2), effect on OATP-B remains unclear. In this study, we aimed examine effects OATP-B. The uptake estrone-3-sulfate, a typical substrate for OATP-B, into embryonic kidney 293 cells stably expressing were evaluated. Juices diluted with buffer,...

Most known interactions between herbal extracts and drugs involve the inhibition of drug-metabolizing enzymes, but little is yet about possible role transporters in these interactions. In this study, we have examined effects used dietary supplements on function organic anion-transporting polypeptide B (OATP-B; OATP2B1), which expressed human intestinal epithelial cells considered to be involved absorption various drugs. Specifically, 15 uptake estrone-3-sulfate, a typical OATP-B substrate,...

OBJECTIVE To investigate whether a difference in the risk for diabetes exists Japanese workers with regard to sleep duration/quality and presence or absence of family history (FHD). RESEARCH DESIGN AND METHODS The researchers conducted prospective, occupational-based study local government employees Sapporo, Japan. Between April 2003 March 2004, 3,570 nondiabetic participants, aged 35–55 years, underwent annual health checkups completed self-administered questionnaire that included...

Coronary artery disease (CAD) is a major problem worldwide. Atherosclerosis and thrombosis underlying CAD involve multiple cell types. New useful diagnostic markers are required. MicroRNAs (miRNAs) class of noncoding RNAs that posttranscriptionally regulate the gene expressions involved in various cellular processes. Endothelial dysfunction implicated early processes athero-thrombosis. Thus, it was hypothesized level vascular endothelium-enriched miRNAs would be altered plasma samples...

Helicobacter Pylori infection was associated with the risk of cardiovascular disease; however, relation between and lipid profile has not been fully established.We measured anti-Helicobacter antibody concentration profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male 1,212 female).The prevalence Pylori-seropositive 46.8% 39.6% men women, respectively. Adjusted mean values low-density lipoprotein (LDL) cholesterol high-density (HDL) were significantly higher lower than-negative...

Rutin, a phenolic compound, has antioxidant, anti-dyslipidaemic, and body weight-reducing effects. We evaluated the anti-arteriosclerotic, effects of rutin-rich Tartary buckwheat. randomly divided 144 adult subjects into an active test food group consuming products containing buckwheat placebo group. Body composition measurements haematological urine tests were performed at weeks 0, 4, 8, 12, 3 after termination. Atherosclerosis index ox-LDL did not significantly differ between groups....

Short fiber-reinforced thermoplastic composites (SFRTPs) have excellent recyclability and processability, but their mechanical properties are weak compared to continuous fiber products. Various studies reported that the addition of GNPs improves SFRTPs, it is unclear what effect different types reinforcing fibers on a hybrid composite system. In this study, adding small amount (1 wt%) graphene nanoplatelets (GNPs) polypropylene was investigated from crystallinity perspective. were mixed with...

It has been well established that dyslipidemia is a significant risk factor for coronary artery disease (CAD), however, the association between fasting triglyceride (TG) and occurrence of CAD controversial. The objective this study was to elucidate relationship TG in middle-aged Japanese men.A cohort 6,966 men (mean +/- SD: 46.6+/-5.2 years) with 10-year follow-up period conducted identify factors CAD. One hundred eleven cases were identified during follow up. Cox proportional hazard model...

The aim of this study is to examine the relationship between self-reported sleep duration and arterial stiffness in a large-scale Japanese study. Cross-sectional Sapporo City, Hokkaido, Japan. Local government employees aged 35-62 years, who underwent annual health checkups from April 2003 March 2004. After excluding those with incomplete data, data 4,268 (males: 3,410) participants were analyzed. N/A. Brachial-ankle pulse-wave velocity (baPWV) was investigated as an indicator stiffness. We...

Lactobacillus plantarum HOKKAIDO (HOKKAIDO strain) was isolated from well-pickled vegetables in Hokkaido, Japan. We report a randomized, double-blind, placebo-controlled study evaluating the effects of L. on immune function and stress markers 171 adult subjects. Subjects were divided into three groups: yogurt group, placebo-1 group who ingested without strain, placebo-2 yogurt-like dessert strain. Hematological tests body composition measurements performed before after 4 8 weeks blinded...

Adiposity is closely associated with the clustering of metabolic risk factors such as high blood pressure, dyslipidemia, and glucose intolerance. Waist circumference body mass index (BMI) are established markers abdominal adiposity general adiposity, respectively. However, it has not been examined whether these two can detect in Japanese subjects.We studied 5,796 middle-aged subjects aged 40-60 years (4,344 males 1,452 females). Metabolic including intolerance were identified according to...

Abstract Background Bisphosphonates are the mainstay drugs for osteoporosis, but in clinical practice, they often ineffective due to low compliance. However, there have been few studies examining compliance on a product-by-product basis or detail Japan. This study aimed clarify bisphosphonate from viewpoints of product selection, formulation, and patient characteristics using medical insurance claim data Japan, generate useful knowledge improving Methods Bisphosphonate records osteoporosis...

What is known and Objective: Low-dose aspirin widely used for prevention of thrombosis, but combined use with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, reduces the antiplatelet effect aspirin. However, there has been no report describing effects timing ibuprofen dose on degree interaction between low-dose ibuprofen. The purpose this study was to predict time-course when administered a single or repeatedly in combination at various time intervals. Methods: We...

The shift towards community-based care in Japan has led to increased medication assistance for older people by non-medical staff. These staff members help take pre-packaged medications, apply patches, and administer eye drops. This study assessed the risks associated with such reviewing medication-related incidents across 106 residential facilities between April 1, 2015, March 31, 2016. An analysis of incident reports showed that all were minor, no serious outcomes. categorized into four...

The objective of this study was to elucidate the relationship between risk factors and coronary artery disease (CAD) in young middle-aged Japanese men.A cohort 2,764 men aged 3544 (mean+/-SD: 42.3+/-2.5) years based on a 10-year followup identify for occurrence CAD conducted. There were 35 cases during follow up; 25 myocardial infarctions 10 angina pectoris. Cox Proportional hazard model used independent CAD. Adjustment made variables including age, body mass index, smoking habit, systolic...

Human organic anion transporter 4 (OAT4) is the only member of OAT family that expressed in placenta and also kidney. Although OAT4 has been shown to transport certain anions as well other members family, fewer numbers substrates have identified for compared with OAT1 OAT3, suggesting substrate specificity greater than members. However, remains be investigated detail. The aim this study was examine effects various drugs on OAT4-mediated estrone-3-sulfate, a typical OAT4, by using human...

Cardiovascular morbidity and mortality are closely associated with hypertension, however, predictors of incident hypertension have not been fully established. We conducted a study aimed at evaluating whether brachial-ankle pulse wave velocity (baPWV) is predictor hypertension. The relation between baPWV, noninvasive index aortic stiffness, was evaluated in cohort 2,278 Japanese normotensive male subjects follow-up 3 years. Of the 2, 278 participants, 151 (6.6%) had during follow-up. After...

A simple fabrication method is demonstrated for surface-enhanced Raman scattering (SERS)-active plasmonic nanoballs, which consisted of Au nanoparticles (NPs) and core–shell polystyrene amino-terminated poly(butadiene) particles, by heterocoagulation NP diffusion. The amount NPs introduced into the particles increases with concentration added to aqueous dispersion particles. When increases, closely packed, three-dimensionally arranged close-packed arrays are formed in shells. Strong SERS...

Background: Quercetin, a phenolic compound, has various functional effects, including anti-oxidant, anti-dyslipidaemic and anti-dysglycemic activities, beneficial effects on cognitive function.Methods: We evaluated the of powder made from quercetin-rich onions (‘Quergold’ ‘Sarasara-gold’) function. In this randomised, double-blind, placebo-controlled study, we randomised 50 adults (25 males 25 females, aged 65–84 years) to consume products (active) or quercetin-poor (placebo) onions....

Soybean is recognized as a beneficial food with various functional components, such β-conglycinin, which improves lipid metabolism. We evaluated the effects of β-conglycinin-rich soybean Nanahomare on triglyceride (TG) levels. In this randomized, double-blind, placebo-controlled study, we divided 134 adult subjects into test and placebo groups that consumed processed containing enriched-β-conglycinin or low-β-conglycinin soybean. Hematological tests body composition measurements were...