Coronary artery disease (CAD) is a major problem worldwide. Atherosclerosis and thrombosis underlying CAD involve multiple cell types. New useful diagnostic markers are required. MicroRNAs (miRNAs) class of noncoding RNAs that posttranscriptionally regulate the gene expressions involved in various cellular processes. Endothelial dysfunction implicated early processes athero-thrombosis. Thus, it was hypothesized level vascular endothelium-enriched miRNAs would be altered plasma samples...

Signal transducers and activators of transcription (STAT) is a family factors which regulate cell proliferation, differentiation, apoptosis, metastasis, immune inflammatory responses, angiogenesis. STAT3 latent cytoplasmic factor that belongs to STATs. has been reported be regulates genes involved with cellular growth, proliferation metastasis. Worldwide, colon cancer one the leading causes cancer-related deaths. Cumulative evidence established essential for progression advanced malignancy....

Objective The current study aimed to investigate the role of myocardial infarction-associated transcript (MIAT)/microRNA-326 (miR-326) axis in regulating migration vascular smooth muscle cells (VSMCs) during progression atherosclerosis (AS). Methods Bioinformatic analysis MIAT and miR-326 two AS-related GEO datasets was performed via online web tool GEO2R. expression 46 paired plasma samples oxidized low-density lipoprotein (ox-LDL)-treated VSMCs analysed RT–qPCR. Western blot used determine...

Little is known about vaccine effectiveness (VE) against nonmedically attended A(H3N2) influenza illness during 2014-2015 when the component appeared to be a poor match with circulating strains.Forty-three eligible school outbreaks in Beijing, China, from November 1, 2014, December 31, were included this study. The VE of trivalent inactivated (IIV3) was assessed preventing laboratory-confirmed among school-age children through case-control design, using asymptomatic controls. Influenza...

Introduction: Time-to-treatment window is critical for managing acute ischaemic stroke. The community healthcare practitioners (CHPs) who deliver frontline care in the health system play an important role stroke prevention and treatment. Methods: A multi-stage sampling design was adopted Guangdong province, China. total of 997 CHPs participated survey were divided into two groups (the awareness group vs unawareness group) according to their knowledge on time management. Logistic regression...

We successfully rescued a patient whose coronary artery perforated following implantation of drug-eluting stent (DES), by deploying stent-graft in symptomatic myocardial bridging.Our case demonstrated that perforation could be handled without difficulty when bridging is confined to the interventricular groove. (

Dry skin pruritus is common in the elderly. Recent reports show that T-cell signal path involved dry pruritus. Zeta-chain-associated protein kinase 70 (ZAP70), as a receptor, may induce interleukin 2 (IL-2) secretion and promote nerve growth factor (NGF) skin. This study aimed to detect alteration of ZAP70 mice model with The C57BL 5 months 22 were used experimental animal. Following 5-day period treatment back mixture acetone-diethyl-ether-water (AEW), exhibited significant increase...

Timely access to emergency treatment during in-hospital care phase is critical for managing the onset of acute ischaemic stroke (AIS), particularly in developing countries. We aimed explore delay and relation door-to-needle (DTN) time ambulance arrivals vs walk-in arrivals.Data were collected from 1276 Chinese AIS patients admitted a general, tertiary-level hospital intravenous thrombolysis. Information on patients' characteristics taken was retrieved registry data medical records. Ambulance...

Angle stable interlocking intramedullary nail (ASIN), a novel technique, has rarely been used for treatment of tibial plateau fractures (TPF). This retrospective study was designed to introduce this ASIN, as well describe the initial experience and verify effectiveness when ASIN management TPF.A cohort 19 cases with closed TPF aged from 18-70 years at least 23 months follow-up November 2008 September 2013 analyzed retrospectively. All patients underwent procedure, which performed by same...

Objectives Migration of macrophages and atherosclerosis result in various diseases, including coronary heart disease. This study aimed to clarify the roles that ghrelin Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) play migration under chronic intermittent hypoxia (CIH). Methods A rat model CIH was constructed changes ROCK2 expression were measured by western blot assay. The migratory ability determined transwell Hematoxylin eosin staining applied detect intima-media...

To investigate whether Tumor Necrosis Factor-alpha (TNFα) is capable of activating Rho kinase pathway which leads to smooth muscle cell proliferation and the intervention function Rosuvastatin, clarify mechanism manner anti-atherosclerosis by Rosuvastatin.Wistar neonate rat cells were cultured, activity was determined methyl thiazolyl tetrazolium (MTT). The expression genes after stimulation TNFα evaluated RT-PCR. Western blot method used measure protein proliferating nuclear antigen (PCNA)...

Elevated free fatty acids (FFAs) are thought to play an important role in the development of insulin resistance. Adiponectin is adipose tissue-secreted protein known for its effects on stimulation acid oxidation. The aim this study was investigate association adiponectin receptor 2 gene variations with FFAs levels subjects normal fasting glucose Chinese Han population.Four common single nucleotide polymorphisms ADIPOR2 were genotyped using TaqMan method perform studies metabolic parameters...

An anomalous origin of the right coronary artery (RCA) is a rare congenital anomaly.If it runs between pulmonary and aorta, may cause acute myocardial infarction (AMI) sudden death. 1-4)Identification anomalies sometimes difficult by angiography because lack three-dimensional information.A 34-year old male patient presented with an inferior wall AMI.Coronary showed that RCA originated from left sinus Valsalva close to main (Fig. 1).Coronary spasm was considered as etiology AMI.Ten months...

Abstract To investigate the effectiveness of cough machine assistance combined with care bundle on mental resilience and self-efficacy burned patients moderate to severe inhalation injury. Totally 98 injury from April 2021 2022 were enrolled in this retrospective analysis. They divided into control group (n = 49, conventional therapy) combined-therapy bundles). The resilience, posttraumatic growth, conducted. arterial blood gas analysis indicators incidence pulmonary infection also...

Objective: To establish a classified evaluation system for recognizing the levels of influenza epidemics and to explore new reporting on epidemics. Methods: The following 3 indicators, including 1) number influenza-like illness, 2) positive rate detection virus nucleic acids, 3) outbreaks were chosen calculate synthetic index classify grades evaluation. Results: 209 weeks during 2013-2017 into 5 grades: Grade 1 110 (52.63%), 2 47 (22.49%), 44 (21.05%), 4 8 (3.83%), 0 week. Conclusion: This...

Objectives:To analyze the correlation between (1) clinical features of respiratory tract infection (RTI) and a poor prognosis in emergency cases common pathogenic microorganisms procalcitonin/C-reactive protein (PCT/CRP) RTIs.Methods: A total 112 patients were enrolled.The characteristics RTIs correlated with microbes.Patients grouped based whether they survived (good prognosis) or died (poor prognosis). Results:(1) Patients mainly elderly, group was on average ~10 years older than good...

Lijuan, Jin; Zhonglin, Xie; Man, Zhang; Qiaobing, Huang; Guoyu, Mo; Chunghua, Jinzheng, Wang Author Information