A5101637703- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Retinal Diseases and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Retinopathy of Prematurity Studies
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Neurological diseases and metabolism
- Circular RNAs in diseases
- Glaucoma and retinal disorders
- Neonatal and fetal brain pathology
- Paranormal Experiences and Beliefs
- Connexins and lens biology
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Noise Effects and Management
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Hearing, Cochlea, Tinnitus, Genetics
- Traumatic Brain Injury and Neurovascular Disturbances
University of Utah
2018-2024
Johannes Gutenberg University Mainz
2019
University College London
2012-2015
National Institute for Health Research
2014-2015
Moorfields Eye Hospital NHS Foundation Trust
2014-2015
Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown cell-VEGFA short-hairpin RNAs VEGFA or VEGF164 via subretinal lentivirus delivery (L-VEGFAshRNA, L-VEGF164shRNA) on retinal structure and function in a rat OIR model. Lectin-stained flat mounts analyzed areas...
Abstract The retina is light-sensitive neuronal tissue in the back of eye. phospholipid composition unique and highly enriched polyunsaturated fatty acids, including docosahexaenoic acid (DHA). While it generally accepted that a high DHA content important for vision, surprisingly little known about mechanisms enrichment retina. Furthermore, biological processes controlled by eye remain poorly defined as well. Here, we combined genetic manipulations with lipidomic analysis mice to demonstrate...
Measurements of retinal neuronal light responses are critical to investigating the physiology healthy retina, determining pathological changes in diseases, and testing therapeutic interventions. The ex vivo electroretinogram (ERG) allows quantification contributions from individual cell types isolated retina by addition specific pharmacological agents evaluation tissue-intrinsic independently systemic influences. Retinal can be measured using a specialized ERG specimen holder recording...
Abstract The retina, a highly metabolic tissue in the central nervous system, consumes most oxygen and energy stores body by mass/volume. Consequently, it is not surprising that retinal ischemia leads to rapid loss of light responses electrical transmission. In this study, we show despite swift decline after circulatory death (decay time constant τ = ∼1-2 min), were able restore mouse rod cone photoreceptor signals from enucleated eyes up 3 h postmortem with significantly better recovery...
Intense noise exposure results in increased nitric oxide (NO)-production by inducible NO-Synthase (iNOS) overexpression. It is unclear, whether the constitutively expressed endothelial synthase (eNOS) may act an otoprotective manner after of cochlea.