A5024918350- Plant Reproductive Biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- Cancer Genomics and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Plant and animal studies
- Protein Structure and Dynamics
- Plant and Fungal Interactions Research
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Genetic and phenotypic traits in livestock
- Plant biochemistry and biosynthesis
- Genetic diversity and population structure
- Polyamine Metabolism and Applications
- Plant Parasitism and Resistance
- Cannabis and Cannabinoid Research
- Fungal and yeast genetics research
- Enzyme Structure and Function
- Evolution and Genetic Dynamics
- Autophagy in Disease and Therapy
University of Oxford
2010-2021
University of Lausanne
2017-2021
Indiana University Bloomington
2019
John Radcliffe Hospital
2017-2019
University of Missouri
2015
Royal Botanic Gardens, Kew
2015
Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing 110 accessions worldwide origins. We show that C. was first domesticated in early Neolithic times East Asia all current drug cultivars diverged ancestral gene pool currently represented by feral plants landraces China. identified candidate genes...
The nonrecombining regions of animal Y chromosomes are known to undergo genetic degeneration, but previous work has failed reveal large-scale gene degeneration on plant chromosomes. Here, we uncover rapid and extensive Y-linked genes in a species, Silene latifolia, that evolved sex de novo the last 10 million years. Previous transcriptome-based studies this species missed unexpressed, degenerate genes. To identify sex-linked genes, regardless their expression, sequenced male female genomes...
Suppressed recombination allows divergence between homologous sex chromosomes and the functionality of their genes. Here, we reveal patterns earliest stages sex-chromosome evolution in diploid dioecious herb
Different protein secondary structure elements have different physicochemical properties and roles in the protein, which may determine their evolutionary flexibility. However, it is not clear to what extent affects way Darwinian selection acts at amino acid level. Using phylogeny-based likelihood tests for positive selection, we examined relationship between across six species of Drosophila. We find that acids form disordered regions, such as random coils, are far more likely be under than...
Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) affects children in sub-Saharan Africa, but diagnosis via tissue biopsy is challenging. We explored a liquid approach using targeted next-generation sequencing to detect the The panel included targets for characteristic detected three of four This analysis demonstrates potential improve BL settings with limited pathology resources. Validation our larger data set needed.
The presence of large genomic regions with suppressed recombination (SR) is a key shared property some sex- and mating-type determining (mat) chromosomes identified to date in animals, plants, fungi. Why such form how they evolve remain central questions evolutionary genetics. smut fungus Microbotryum lychnis-dioicae basidiomycete which dimorphic mat have been reported, but the size, age, dynamics SR region remains unresolved. To identify M. study its evolution, we sequenced 12 genomes (6...
Abstract Suppressed recombination around a sex-determining locus allows divergence between homologous sex chromosomes and the functionality of their genes. Here, we reveal patterns earliest stages sex-chromosome evolution in diploid dioecious herb Mercurialis annua on basis cytological analysis, de novo genome assembly annotation, genetic mapping, exome resequencing natural populations, transcriptome analysis. Both mapping individuals across species range independently identified largest...