Melanoma is a heterogeneous tumor with subgroups requiring distinct therapeutic strategies. Genetic dissection of melanoma and identification agents are great interest in the field. These efforts will ultimately lead to treatment strategies, likely combinatorial, based on genetic information.To identify "driver" genes that can be targeted therapeutically, we screened metastatic melanomas for somatic mutations by exome sequencing followed selecting those available therapies directed gene...

Dermoscopy is a non-invasive imaging method that enables the evaluation of pigmented and non-pigmented skin lesions. More recently, dermoscopy has been recognized as an effective tool in diagnosis nail diseases.To evaluate dermoscopic features psoriasis to assess relationship between these disease severity.A total 67 patients with clinically evident (14 women, 53 men) were prospectively enrolled. Following thorough clinical examination, graded according Nail Psoriasis Severity Index...

BACKGROUND Psoriasis is a common chronic inflammatory dermatosis. Systemic immune inflammation index (SII) an inflammation-based biomarker, which has been shown to be effective prognostic factor in diseases with inflammation-related etiology. OBJECTIVES The aim of the present study was investigate potential efficacy SII as patients psoriasis and psoriatic arthritis. MATERIALS AND METHODS This developed based on analysis medical records psoriasis. retrospectively evaluated participants for...

Over the years, clinical studies have provided new knowledge about dermoscopic features of diseases cutaneous annexes. It seems that dermoscopy has opened a morphological dimension in diagnosis and management hair disorders onychopathies.To identify describe onychomycosis.A total 81 consecutive patients with onychomycosis (55 men 26 women) were prospectively enrolled present study. For each patient, all fingernails toenails evaluated examinations. Mycological tests performed by potassium...

Vitiligo is an acquired depigmentation disorder, and oxidative stress suggested to have a major role in its aetiopathogenesis. To assess whether has greater generalized than localized vitiligo. We assessed 31 patients with active vitiligo (17 localized, 14 generalized) 38 healthy controls. Serum total oxidant status (TOS), antioxidant (TAS) index (OSI) were determined. Patients had significantly lower TAS higher TOS OSI values Both associated values, compared controls, all three did not...

Trachyonychia is a disease of the nail matrix that can present as either opaque or shiny trachyonychia. Although it often idiopathic, be associated with conditions such alopecia areata (AA), psoriasis, and lichen planus. Isolated psoriasis (NP) mimic trachyonychia, making diagnosis challenging. Dermoscopy, non-invasive imaging technique, has proven useful in identifying NP features. This report presents two cases: one isolated psoriatic trachyonychia another AA-associated In both cases,...

Telogen effluvium (TE) is a common form of non-scarring alopecia, characterized by excessive shedding telogen club hairs.The aim the present study was to investigate patient characteristics, laboratory parameters, and treatment strategies in TE.Electronic records 3028 patients were retrospectively analyzed. Demographic clinical data, as well serum parameters screening for iron, vitamin B12, D, folate zinc deficiencies, thyroid function, ANA titers, evaluated.In group, most frequently...

Nail psoriasis poses a diagnostic challenge in context of clinical findings that are not evident. We aimed at exploring dermoscopic nail and assessing the relationship between these features with disease severity risk arthritis.We enrolled 35 patients (26 men, 9 women) severe (Nail Psoriasis Severity Index [NAPSI] score more than 50). A complete evaluation, including musculoskeletal assessment videodermoscopic examination all nails, was carried out for each patient.Splinter haemorrhage most...

The role of oxidative stress in the pathogenesis psoriasis has been investigated previous studies with conflicting results. On other hand, well-established treatments currently used exert their effects via a boost stress. Recently, strong positive association between psoriasis, metabolic syndrome and dyslipidemia also described showing complex nature disease.To examine thiol/disulphide homeostasis, newly developed homeostasis assay evaluate possible psoriasis.The study population included 92...

OBJECTIVES: In this study, it was aimed to investigate whether or not platelet-rich plasma (PRP) causes intraabdominal adhesions and therefore, PRP can be used safely in intra-abdominal operations.METHODS: Of the total of 35 animals, 5 were as donors for preparation (PRP).The surgical procedures performed on remaining 30 animals.These rats randomized divided into 3 groups 10.In Group 1, no adhesion induction performed.Adhesion induced by cecal abrasion peritoneal resection model Groups II...

Acne vulgaris is a worldwide disease, affecting 85% of adolescents and young adults. Psychological burden the disease can be profound may even exceed its physical impact. Adolescents often seek information from variety sources, which contributes misinformation misconceptions. The aim present study was to investigate perspectives attitudes adults towards acne.

Tattoos are popular body decorations mainly done for cosmetic purposes. Regarded as a form of self-expression, tattoos reflect the character person wearing it. However, tatoos persistent visual markings on body, frequently misperceived by others causing tattooed to seek removal. Today most can be successfully treated with laser ablation. Here we present case generalized allergic contact dermatitis after tattoo removal which is rare adverse reaction

Isotretinoin (Iso) is the most effective drug against severe nodulocystic acne. As a synthetic oral retinoid, Iso exerts its actions by modulating cell growth and differentiation. Targeting all pathophysiologic processes in acne development, has been considered to be an unique drug, however it several side effects. While chelitis, xerosis, ocular sicca, arthralgia, myalgia, headache, hyperlipidemia are common effects, teratogenicity depressive symptoms concerning ones. In addition, unusual...

Taxanes and anthracyclines are considered as fundamental drugs for the treatment of a broad range cancers. They have several side effects, which may limit their usage. Drug-induced nail pigmentation (DHNP) has been reported one most striking dermatological effect both taxanes doxorubicin.This study aimed to evaluate compare pigmentary effects doxorubicin with help onychoscopy.Forty-one consecutive patients (30 women, 11 men) diagnosis cancer (16 gastric cancer, 25 breast cancer) were...

Toxic epidermal necrolysis-like lupus erythematosus (TEN-LE) is a very rare variant of LE, which characterized by extensive areas necrolysis indistinguishable from drug induced Stevens-Johnson syndrome (SJS)/TEN. Here, we describe an unusual presentation in whom acute was the initial diagnostic manifestation LE. Our patient fulfilled criteria for definite diagnosis systemic addition she had history recent exposure to multiple drugs, some are known cause SJS/TEN and drug-induced subacute...

Palmoplantar psoriasis is classified as nonpustular palmoplantar (NPPP) or pustulosis (PPP).

Ibrutinib is an oral covalent inhibitor of the Bruton’s tyrosine kinase pathway and approved for treatment B-cell malignancies including chronic lymphocytic leukaemia, mantle cell lymphoma, Waldenström’s macroglobulinaemia. It generally a drug choice high-risk patients with indolent lymphomas. The safety profile ibrutinib appears to be tolerable, well-known side effects such as infections haematologic complications. Additionally, dermatological adverse reactions therapy have been reported...