A5003473604- Ovarian function and disorders
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian cancer diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Hypothalamic control of reproductive hormones
- Assisted Reproductive Technology and Twin Pregnancy
- BRCA gene mutations in cancer
- Dysphagia Assessment and Management
- Esophageal and GI Pathology
- Sexual Differentiation and Disorders
- Endometrial and Cervical Cancer Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Sperm and Testicular Function
- Healthcare and Venom Research
- FOXO transcription factor regulation
- Neurosurgical Procedures and Complications
- Protein Kinase Regulation and GTPase Signaling
- Urticaria and Related Conditions
- Head and Neck Surgical Oncology
- Genetics, Aging, and Longevity in Model Organisms
Faculdade de Medicina do ABC
2013-2024
Durban University of Technology
2020
Azienda Ospedaliera Universitaria Pisana
2019
Center for Human Reproduction
2015
Fertility Medical Group
2014
University of Naples Federico II
1986
Several biomarkers of ovarian reserve have been proposed as possible predictors the response to controlled stimulation (COS). We aimed evaluate age, FSH, AMH, antral follicle count (AFC), and prediction index (ORPI), potential COS.Cross-sectional study enrolling 188 infertile women who underwent first cycle IVF/ICSI. AFC was evaluated; serum FSH AMH levels were measured by ELISA. ORPI calculated x AFC/patient´s age.As expected, hypo-responder group had less retrieved oocytes, MII, embryos...
Important candidate genes involved in the ovarian response to exogenous FSH are estrogen receptor (ESRs), since effects of estrogens on follicle growth, maturation and oocyte release. It is known that some markers stimulation can help personalize treatment, adjusting dose rFSH, thus preventing excessive wear patient. Inspired this information we aimed analyze four different polymorphisms ESR1: rs2234693/T-397C (PvuII) rs9340799/A-351G (Xbal) ESR2: rs4986938/G1082A (RsaI) rs1256049/A + 1730G...
Intervertebral disc degeneration (DD) is an important cause of low back pain and its precise aetiology not fully understood, being attributed to cumulative environmental, biomechanical genetic effects. The vitamin D plays a key role in regulation calcium homeostasis bone mineralization, exerting biological activities by binding high-affinity receptor (VDR). Polymorphisms VDR gene were previously associated with DD process, however conflicting results. Here, we aimed investigate the influence...
It is known that some markers of ovarian stimulation can help to personalize the treatment, adjusting dose exogenous rFSH, thus preventing excessive wear patient. We aimed evaluate Ala307Thr and Asn680Ser genotypes FSHR gene in infertile women correlate findings with results response assisted reproduction outcomes.Cross-sectional study covering 149 submitted treatment. Genotyping variants were performed using TaqMan methodology by real time PCR. FSH estradiol measured ELFA. The data was...
Background: In human assisted reproduction, the ovarian response to exogenous recombinant Follicle-stimulating Hormone (FSH) therapy is variable and difficult predict. The standard protocol of hyperstimulation can result in satisfactory response; however, an unsatisfactory necessitates FSH dose adjustment or results syndrome (OHSS). Polymorphisms AMH AMHR2 genes appear affect hormone biological activities, thus affecting follicle recruitment development, leading infertility. We aimed...
Background Single nucleotide variants (SNVs) FSHB :c.-211G>T, FSHR :c.919G>A, and :c.2039G>A were reported to be associated with the variability in FSH LH levels, vitro fertilization (IVF) outcomes. In this study, we aimed evaluate effects of FSHR: c.2039G>A variants, alone combined, on hormonal profile reproduction outcomes women endometriosis. Methods A cross-sectional study was performed comprising 213 infertile Brazilian endometriosis who underwent IVF...
Abstract Background Endometriosis is a chronic condition whose pathophysiology unknown, but there evidence suggesting link with oxidative stress. Paraoxonase serum enzyme which circulates associated high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the levels PON-1 activity in women endometriosis different stages disease (minimal/mild moderate/severe). Methods 80 infertile diagnosed by laparoscopy/laparotomy histologic confirmation were...
Abstract Estrogen plays an important role in the human reproductive system and its action is mediated mainly by two specific receptors: α (ERα) β (ERβ). There are polymorphic variants both ER genes, studies showed their association with outcomes. We aimed to determine distribution of ERα ERβ gene polymorphisms idiopathic, infertile Brazilian patients a case–control study comprising 187 men nonobstructive azoospermia (NOA, n = 78) or severe oligozoospermia (SO, 109) 216 fertile men. Detection...
Estrogens are important factors in the female reproductive functions and processed by a number of enzymes along their metabolic pathway. The COMT gene constitutes crucial element estrogen metabolism is assumed to be involved development Premature Ovarian Insufficiency (POI). This study aimed determine whether presence Val/Met polymorphism (rs4680) associated risk developing POI. In this case–control study, we evaluated 96 infertile women with POI 120 fertile as controls, after obtaining...
Polymorphisms in the gene encoding bone morphogenetic protein 15 (BMP15) can result inhibited secretion or lowered bioactivity of BMP15 protein. levels are associated with follicle-stimulating hormone receptor (FSHR) action on granulosa cells, wherein FSHR increases sensitivity ovarian follicles to (FSH). In this study we evaluated polymorphisms A905 > G/rs3897937, C901 T/rs17003221, and C-9 G/rs3810682 infertile Brazilian women terms anti-Mullerian (AMH), FSH, estradiol serum levels, as...
Sao Paulo State Univ UNESP, Ctr Human Reprod Prof Franco Jr, Paulista Diag Res & Training, Dept Gynecol Obstet,Botucatu Med Sch, Ribeirao Preto, Brazil
Kisspeptin has been identified as a key regulatory protein in the release of gonadotropin-releasing hormone (GnRH), which subsequently increases gonadotropin secretion during puberty to establish reproductive function and regulate hypothalamic-pituitary-gonadal axis. The effects variants KISS1, KISS1R, GNRHR genes their possible association with assisted reproduction outcomes remain be elucidated. In this study, we used next-generation sequencing investigate associations genetic diversity at...
Dynamic mutations in the 5′ untranslated region of FMR1 are associated with infertility. Premutation alleles interfere prenatal development and increase infertility risks. The number CGG repeats that causes highest decrease ovarian reserves remains unclear. We evaluated effect repeat lengths on vitro fertilization (IVF) treatment outcomes 272 women within normal range. length was investigated via PCR capillary electrophoresis. Alleles were classified as low-normal, normal, high-normal. Serum...