A5030495709- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Liver Disease Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Drug Transport and Resistance Mechanisms
- Global Cancer Incidence and Screening
- Digestive system and related health
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- DNA Repair Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Cholesterol and Lipid Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Cancer Risks and Factors
- Metabolism and Genetic Disorders
- Liver Disease and Transplantation
University of Modena and Reggio Emilia
2010-2022
Azienda Ospedaliero-Universitaria di Modena
1998-2018
Azienda Sanitaria Unità Locale di Reggio Emilia
2017
Fondazione IRCCS Istituto Nazionale dei Tumori
1993-2015
German Cancer Research Center
2015
Heidelberg University
2015
University of Lübeck
2015
University of Milan
1981-2015
Instituto de Investigación Biosanitaria de Granada
2015
Universidad de Granada
2015
<h3>Background</h3> The UK introduced financial incentives for management of atrial fibrillation (AF) in 2006, after which there was an increase the proportion AF patients diagnosed as resolved. Removal Scotland provides a natural experiment to investigate effects withdrawal incentive on diagnosis resolved AF. <h3>Aim</h3> Investigate introduction and <h3>Design & setting</h3> Cohort study large database primary care records, before April 2006 Scotland, England Northern Ireland, their...
Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which responsible for <1% of all colorectal cancer (CRC) cases. The syndrome characterised by the development hundreds to thousands adenomas in colorectum. Almost patients will develop CRC if they are not identified and treated at an early stage. as autosomal dominant trait caused mutations APC gene. Recently, second gene has been that also gives rise colonic polyposis, although phenotype less severe than typical...
OLORECTAL CANCER (CRC) is the third most common cancer worldwide and second leading cause of cancer-related death. 1 Lynch syndrome, also known as hereditary nonpolyposis colorectal (HNPCC), form CRC, accounting for 1% to 3% all these tumors.It an autosomaldominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes (ie, MSH2, MLH1, MSH6, PMS2).
Abstract Purpose: Many studies have evaluated the role of high levels microsatellite instability (MSI) as a prognostic marker and predictor response to chemotherapy in colorectal cancer (CRC); however, results are not conclusive. The aim this study was analyze significance MSI (MSI-H) CRC patients relation fluorouracil-based chemotherapy. Experimental Design: In three different institutions, 1,263 with were tested for presence MSI, CRC-specific survival then analyzed status, chemotherapy,...
The authors studied the familial occurrence of tumors in 154 individuals with gastric cancer by reviewing clinical data and genealogical tree all patients registered 1986 through 1987 Local Health Care District Modena, Italy, for stomach. Crude age-adjusted (world population) incidence rates were 34.0 21.4 new cases/100,000/year, respectively, men, 24.5 10.9 women, respectively. Among first-degree relatives there 30 cases carcinoma versus 15 a control group matched age sex (Mantel-Haenszel...
Abstract Biallelic germline mutations in the base excision repair gene MYH have been reported patients with multiple colorectal adenomas and cancer sporadic FAP not showing a detectable APC mutation. In this study, prevalence of common Y165C G382D variants was examined 70 FAP/AAPC no mutation family history compatible recessive inheritance. addition, 141 normal‐population adenoma (mean number adenomas, 2.8; range, 1–9) 52 clean colon controls were studied. The entire coding region analyzed...
Colonic adenomas represent the natural precursor lesions of most colorectal cancers. The treatment choice is endoscopic polypectomy. However, after removal, polyps recur in a large fraction cases. Thus, we evaluated effect antioxidant vitamins or lactulose on recurrence rate adenomatous polyps. After polypectomy, 255 individuals were randomized into three groups. Group 1 was given vitamin A (30,000 IU/ day), C (1 g/day), and E (70 mg/day); 2 (20 g/day); 3 received no treatment. Forty-six...
Abstract BACKGROUND The Muir–Torre syndrome (MTS) is an autosomal‐dominant genodermatosis characterized by the presence of sebaceous gland tumors, with or without keratoacanthomas, associated visceral malignancies. A subset patients MTS considered a variant hereditary nonpolyposis colorectal carcinoma, which caused mutations in mismatch‐repair genes. objective current study was to evaluate whether combined clinical, immunohistochemical, and biomolecular approach could be useful for...
<b>Background:</b> Population based colorectal cancer survival among patients diagnosed in 1985–89 was lower Europe than the USA (45% <i>v</i> 59% five year relative survival). <b>Aims:</b> To explain this difference using a new analytic approach for between 1990 and 1991. <b>Subjects:</b> A total of 2492 European 11 191 US adenocarcinoma registered by 10 nine registries. <b>Methods:</b> We obtained clinical information on disease stage, number lymph nodes examined, surgical treatment....
The first year of registration colorectal tumors in a predominantly urban population (263,546 inhabitants) northern Italy gave us the opportunity to investigate: (a) incidence (crude, age-specific, age-standardized) both cancer and polyps their localization; (b) familial occurrence these neoplasms; (c) if data could fit into "Adenoma-Carcinoma Sequence." Crude was 52.8 new cases/100,000 1984, with 53.4 cases men 52.2 women. corresponding figures for were 59.6 cases, 83.4 37.3 increased age...
The activity of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and 7a-hydroxylase, the enzymes controlling rate hepatic synthesis, respectively, cholesterol bile acids, microsomal content were evaluated in 25 patients with gallstones 17 subjects without gallstones.The same quantities estimated 16 additional given chenodeoxycholic (CDCA) or ursodeoxycholic acid (UDCA) at a dose 15 mglkg per day order to investigate comparative effect short term (7 days) administration two acids on sterol...
To elucidate the mechanism responsible for bile acid-induced changes of biliary lipid secretion, we evaluated flow and output acids, cholesterol, phospholipids, alkaline phosphatase activity in seven cholecystectomized subjects with a balloon occludable T-tube during two experimental periods: (a) depletion endogenous acid pool (b) replacement by means duodenal infusion individual such as deoxycholic (DCA), chenodeoxycholic (CDCA), cholic (CA), ursodeoxycholic (UDCA) acids. Bile flow,...