A5043985132- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Animal Virus Infections Studies
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Congenital Anomalies and Fetal Surgery
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Liver Disease Diagnosis and Treatment
- Dermatological and COVID-19 studies
- Biosensors and Analytical Detection
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Advanced biosensing and bioanalysis techniques
- Brucella: diagnosis, epidemiology, treatment
- Herpesvirus Infections and Treatments
- Salivary Gland Disorders and Functions
- Immunotherapy and Immune Responses
Universidade Federal de Goiás
2014-2024
Fundação de Apoio a Pesquisa do Estado de Goiás
2017
University of Parma
1992-1998
University of Naples Federico II
1986
High viral and/or antigen load may be an important cause of the T cell hyporesponsiveness to hepatitis B virus (HBV) antigens that is often observed in patients with chronic HBV infection. Reduction and by lamivudine treatment represents ideal model for investigating this hypothesis. HLA class II restricted responses serum levels HBV-DNA, HBsAg, HBeAg were studied before during 12 e positive active assess possible correlations between vigor response. Cell proliferation nucleocapsid peptides...
COVID-19 is characterized by diverse clinical outcomes that include asymptomatic to mild manifestations or severe disease and death. Infection SARS-CoV-2 activates inflammatory metabolic responses drive protection pathology.
Abstract This study aimed to estimate the risks of adverse infant outcomes in first year life related prenatal Zika virus (ZIKV) exposure. A prospective cohort pregnant women with rash was recruited Central-West Brazil a post-epidemic period (January 2017 April 2019). We evaluated participants’ medical histories and performed ZIKV diagnostic testing using molecular (reverse transcription polymerase chain reaction [RT-PCR]) serologic (immunoglobulin [Ig]M plaque reduction neutralization tests...
We analyzed fecal samples from hospitalized children up to three years of age with acute gastroenteritis at Campo Grande, Mato Grosso do Sul, Brazil, May 2000-January 2004. Astrovirus and calicivirus were detected by Reverse Transcription-Polymerase Chain Reaction adenovirus was using the Rotavirus Adenovirus combined immunoenzyme assay. Astrovirus, rates 3.1%, 3.6% 7.6%, respectively. These results re-emphasize need for establishment regional vigilance systems evaluate impact enteric...
COVID-19 pandemic continues to be a priority in public health worldwide, and factors inherent SARS-CoV-2 pathogenesis genomic characteristics are under study. Investigations that evaluate possible risk for infection, clinical manifestations, viral shedding different specimens also need clarify associations with prognosis disease outcomes.In this study, we evaluated positivity estimated loads by real-time RT-PCR stool, sera, urine samples from 35 patients, positive RNA molecular test...
To evaluate the secondary attack rate (SAR) in children and adolescents, contacts of essential activities workers who were infected by SARS-CoV-2; to describe associated clinical epidemiological data.A cross-sectional study conducted adolescents aged 5 19 years age, that household parents other relatives SARS-CoV-2 city Goiânia, Central Brazil, from March October 2020. Sociodemographic data collected all participants. Nasopharyngeal oropharyngeal swabs tested for RNA using real-time reverse...
Caliciviruses (Norovirus and Sapovirus) are important causes of acute gastroenteritis, with Norovirus (NoV) considered the leading cause epidemic non-bacterial gastroenteritis; however, molecular epidemiological data circulating Calicivirus (CV) strains among day-care children still scarce. The role asymptomatic CV excretion on viral transmission also remains poorly understood. aim present study was to monitor occurrence NoV Sapovirus (SaV) in a center describe epidemiology strains. Genomic...
Varicella vaccine was introduced into the Brazilian Immunization Program in October 2013, as a single-dose schedule administered at 15 months of age. Its effectiveness had not yet been assessed country.A matched case-control study carried out São Paulo and Goiânia (Southeast Midwest regions, respectively), Brazil. Suspected cases, were identified through prospective surveillance established sites. All cases specimens from skin lesion collected for molecular laboratory testing. Cases...
Arboviruses are associated with human disease, and non-human primates (NHPs) important primary hosts. This study shows the detection of antibodies to Oropouche virus (OROV) in NHPs either living urban parks or acclimatized at Wild Animal Screening Center, Goiânia city.Fifty blood samples were analyzed by hemagglutination-inhibition neutralization assays.Two monkeys (Alouatta caraya) had OROV both techniques.This is first report demonstrating Goiás State may represent introduction/circulation...
The objective of this study was to describe the circulation caliciviruses in West Central region Brazil and its correlation with children's gender age, as well year months sample collection. Reverse transcriptase-polymerase chain reaction performed detect human calicivirus genome 1006 fecal samples that were collected Goiânia (n = 696) Brasília 310). Viral RNA detected 8.6% samples. No significant difference viral prevalence found regarding gender, age or sample. However, it observed...
The epidemiological features of rotavirus A (RVA) infection differ between children from developing and developed countries which could result in differences vaccine efficacy around the world. To evaluate impact RotarixTM on RVA prevalence, we monitored genotypes circulating Goiânia by monitoring virus faecal samples that had or not been previously vaccinated. From February-November 2008, 220 were collected seven day-care centres. detection was performed two methodologies results confirmed...
The human adenovirus (HAdV) infection can cause severe disease in immunocompromised patients, such as those undergoing allogeneic hematopoietic stem cell transplant (ASCT). main objective of this study was to prospectively monitor ASCT recipients for HAdV occurrence a reference center Brazil, and also correlate viral positivity, load, molecular variant, clinical symptoms, patients' prognosis. From October/2012 October/2014, blood feces 21 were screened by Nested-PCR. Viral loads determined...
Nonstructural protein 4 (NSP4), encoded by group A rotavirus genome segment 10, is a multifunctional and the first recognized virus-encoded enterotoxin. The NSP4 gene has been sequenced, five distinct genetic groups have described: genotypes A-E. A, B, C detected in humans. In this study, NSP4-encoding of human strains different G P collected from children between 1987 2003 three cities West Central region Brazil was characterized. 153 rotavirus-positive fecal samples amplified reverse...
Were analyzed 648 serum samples from laboratory staff in Goiânia, Goiás aiming detection of three serological markers HBV: HBsAg, anti-HBsAg and anti-HBcAg. The HBsAg anti-HBcAg positive were also for HBeAg, anti-HBeAg anti-HBcAgIgM markers. HBV infection rate 24.1% was observed and, them, 0.7% HBsAg. Viral DNA detected by PCR two samples. A vaccination index 74.5% a global 89.9% response to observed. direct work with biological fluids as well cleaning workers represented significant risks...
To determine the positivity rate of human bocavirus (HBoV) 1 and 3 among children who presented with acute gastroenteritis symptoms during period 1994-2004 in Central-West Region Brazil, 762 faecal samples were tested using polymerase chain reaction (PCR) for detection HBoV DNA. Primers a segment non-structural viral protein (NS1) gene HBoV-1 HBoV-3 used. Twelve HBoV-positive further characterised via genomic sequencing phylogenetic analysis. Of tested, 5.8% (n = 44) positive or co-infection...
Dengue is one of the most prevalent infectious tropical diseases in world, with high incidence over 100 countries.Rapid and reliable diagnosis dengue great importance for public health.To simplify molecular diagnostics, isothermal amplification techniques have recently emerged as an alternative to conventional methods deoxyribonucleic acid (DNA) amplification.Here, we developed a one-step method virus detection from real sample based on RT-LAMP (reverse transcription-loop mediated...