Emerging evidences have indicated that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of cancers. Dysregulation lncRNA MIR31HG has recently been reported several types cancers, researches on function cancers suggested could act as either oncogene or tumor suppressor. But functional involvement not studied hepatocellular carcinoma (HCC).In this study, MTS assays, colony formation assay, Wound-healing Transwell assy, xenografts experiments were used to...

Bacterial biofilms play a crucial role in the emergence of antibiotic resistance and persistence chronic infections.

To assess the predictive role of pretreatment ki67 and Ki67 changes in breast cancer (BC) patients treated with neoadjuvant chemotherapy (NAC) various molecular subtypes. 1010 BC who had undergone anthracycline taxane-based NAC from January 2012 to July 2017 were retrospectively analyzed. Clinical pathological parameters retrieved factors for response evaluated. 705 showed clinical (cRes), 131 acquired pathologic complete (pCR). Patients higher (≥ 14%), tumor size ≥ 4 cm, positive nodal...

Neoadjuvant chemotherapy has been widely used in locally advanced and inflammatory breast cancer. Generally, complete pathological response after neoadjuvant treatment predicts survival. Studies have shown that patient-derived organoids can be cancer research drug development. Therefore, we aimed to generate a living organoid biobank from biopsy samples predict the of patients chemotherapy. We generated receiving When patient received chemotherapy, were treated with similar drugs, thereby...

The combination of some parameters, including the neutrophil to lymphocyte ratio (NLR), platelet (PLR), monocyte (LMR) and (NMR), which are associated with patient prognosis, our goal is find best indicator predict efficacy neoadjuvant chemotherapy（NAC）in breast cancer patients. A cohort 808 patients treated NAC subsequent surgery was analyzed retrospectively. In addition, 2424 people without served as normal group, included three-fold more individuals compared group. Receiver operating...

Abstract Ferroptosis is a new form of regulated cell death (RCD), and its emergence has provided approach to the progression drug resistance breast cancer (BRCA). However, there still great gap in study ferroptosis-related genes BRCA, especially luminal-type BRCA patients. We downloaded mRNA expression profiles corresponding clinical data patients from Molecular Taxonomy Breast Cancer International Consortium (METABRIC) The Genome Atlas (TCGA) databases. Then, we built prognostic multigene...

Based on TCGA, GTEx, and TIMER databases various bioinformatics analysis methods, the potential biological roles of cuprotosis-related genes in pancreatic cancer were deeply explored, a predictive model for patients was constructed. We downloaded RNA-Seq data clinicopathological 179 tissues 332 adjacent normal from TCGA GTEx databases. The differential expression tissue analyzed, LASSO regression algorithm used to construct prediction verify validity prediction. algorithm, composed three...

Pyroptosis is a new form of programmed cell death (PCD), also known as cellular inflammatory necrosis. Its discovery has resulted in novel approach to the progression and medication resistance breast cancer (BC). However, there still significant gap investigation pyroptosis-related genes BC.The mRNA expression profiles clinical data BC patients were obtained from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases. Then, using TCGA cohort, we created predictive multigene...

Laser shock peening (LSP) is an advanced surface modification technology and widely used for the fatigue strengthening of metallic materials. In this study, effects LSP on structure, microhardness, residual stress, properties 34CrNiMo6 were experimentally investigated. The axial tests carried out S–N curves fitted to evaluate strength specimens before after LSP. fractures characterized. results indicated that high-cycle at 10 6 cycles increased from 417 MPa 448 treatment. CRS formed layer...

Abstract Background Chemotherapy is widely used to treat hepatocellular carcinoma (HCC). Although sorafenib (SO) the only chemotherapy drug approved by FDA for treatment of HCC, it associated with several disadvantages including low water solubility, bioavailability, lack targeting and easily causes systemic toxicity. In recent years, nanocarriers have shown promise in delivery effectively solve these problems. Herein, we SO-loaded overcome defects during HCC. Specifically, encapsulated...

Protein-stabilized gold nanoclusters (Prot-Au NCs) have been widely used in biosensing and cell imaging owing to their excellent optical properties low biotoxicity. However, several Prot-Au NCs reported the literature do not retain biological role of protein, which greatly limits ability directly detect biomarkers. This study demonstrated for first time successful synthesis dual-function avidin-stabilized (Av-Au using a one-pot method. The resulting Av-Au exhibited intense blue red emissions...

Abstract Mitochondrial function, as the core of cell's energy metabolism, is firmly connected to cancer metabolism and growth. However, involvement long noncoding RNAs (lncRNAs) related mitochondrial function in breast (BRCA) has not been thoroughly investigated. As a result, objective this research was dissect prognostic implication function-related lncRNAs their link immunological microenvironment BRCA. The Cancer Genome Atlas (TCGA) database used acquire clinicopathological transcriptome...

Breast cancer patients show significant heterogeneity in overall survival. Current assessment models are insufficient to accurately predict patient prognosis, and for predicting treatment response lacking. We evaluated the relationship between various immune cells breast confirmed association infiltration progression. Different bioinformatics statistical approaches were combined construct a robust infiltration-related gene signature prognosis responses immunotherapy chemotherapy. Our...

This study is aimed at exploring the potential mechanism of PPAR signaling pathway in breast cancer (BRCA) and constructing a novel prognostic-related risk model. We used various bioinformatics methods databases to complete our exploration this research. Based on TCGA database, we use multiple extension packages based R language for data conversion, processing, statistics. LASSO regression analysis establish model BRCA. And combined online websites, including GEPIA, ImmuCellAI, TIMER, GDSC,...

Effective predictors of the response to neoadjuvant chemotherapy (NAC) are still insufficient. This study aimed investigate predictive value serum lipid profiles for NAC in breast cancer patients.A total 533 patients who had received were retrospectively studied. The pretreatment lipids, including cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density (LDL-C), and lipoprotein-α, clinicopathological characteristics collected assess their roles.Breast significantly...

The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) neoadjuvant chemotherapy (NAC) in breast cancer patients assess role Fib as a predictive factor.Data from 1004 consecutive with invasive who received NAC subsequent surgery were retrospectively analysed. Both univariate multivariate analyses based on logistic regression model performed identify clinicopathological factors associated pCR NAC. Cox...

The role of postmastectomy radiation therapy (PMRT) in clinical T1-2N1 breast cancer patients who achieve axillary pathological complete response (ypN0) after neoadjuvant chemotherapy (NAC) is controversial.Data from cT1-2N1 converted to ypN0 NAC and subsequent surgery were retrospectively analyzed. Disease-free survival (DFS) overall (OS) estimated using the Kaplan‒Meier method. Univariate multivariate Cox regression models applied investigate correlations between or parameters...

The aim of this study was to assess the prognostic influence Ki67 index changes in patients with primary triple-negative breast cancer (TNBC) treated neoadjuvant chemotherapy (NAC), and evaluate whether combination residual disease (RD) tumor-infiltrating lymphocytes (TILs) provides additional information for group.Data from 109 TNBC RD after NAC were analyzed retrospectively. TIL levels investigated associations recurrence-free survival (RFS) overall (OS) using Kaplan-Meier Cox...

Excellent response of the primary tumor after neoadjuvant therapy may indicate a better axillary status in breast cancer. However, this treatment correlation has not been investigated Chinese cancer patients.Patients diagnosed with and treated were included retrospective study, conducted at comprehensive institution China. Clinicopathological factors baseline analyzed by univariate multivariate analyses. Furthermore, association rules analyses used to investigate between pathologic that...

Recent studies have shown that the mediator complex (MED) plays a vital role in tumorigenesis and development, but of MED16 (mediator subunit 16) breast cancer (BC) is not clear. Increasing evidence has mTOR pathway important for tumour progression therapy. In this study, we demonstrated signalling regulated by expression level ER+ cancer. With analysis bioinformatics data clinical specimens, revealed an elevated luminal subtype tumours. We found knockdown significantly inhibited cell...